Arbutus Biopharma Corp
Business
Arbutus Biopharma Corporation is a clinical-stage biopharmaceutical company focused on infectious disease, principally developing therapies for chronic hepatitis B and advancing its lipid nanoparticle (LNP) delivery technology through ownership and a license to Genevant. It develops imdusiran (AB-729), a GalNAc-conjugated subcutaneous RNAi therapeutic, and AB-101, an oral PD-L1 inhibitor, while seeking to maximize and license its LNP delivery platform and defend related intellectual property. Key activities include clinical development of cHBV product candidates, collaborations, licensing and royalty arrangements, and IP litigation. The company conducts global clinical trials, seeks regional partnerships (including Greater China and Taiwan), and pursues international patent enforcement and licensing channels.
Summary from filing dated 2025-03-27
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Revenue | 14 | 6 | 18 | 39 | 11 | |
| Research and development | 25 | 54 | 74 | 84 | 66 | |
| General and administrative | 16 | 22 | 22 | 18 | 17 | |
| Change in fair value of contingent consideration | −2 | 3 | 69,000 | 2 | 2 | |
| Restructuring costs | 13 | 4 | 0 | — | 0 | |
| Total operating expenses | 52 | 82 | 96 | 104 | 85 | |
| Loss from operations | −38 | −76 | −78 | −65 | −74 | |
| Interest income | 4 | 7 | 6 | 2 | 127,000 | |
| Gain on sale of property and equipment | 674,000 | 0 | — | — | — | |
| Interest expense | −97,000 | −137,000 | −459,000 | — | — | |
| Foreign exchange gain / (loss) | 14,000 | −49,000 | 25,000 | −22,000 | 5,000 | |
| Total other income | 5 | 6 | 5 | 444,000 | −3 | |
| Net loss | −34 | −70 | −73 | −69 | −76 | |
| Basic (in USD per share) | −0.17 | −0.38 | −0.44 | −0.46 | −0.83 | |
| Diluted (in USD per share) | −0.17 | −0.38 | −0.44 | −0.46 | −0.83 | |
| Basic (in shares) | 192 | 186 | 166 | 151 | 106 | |
| Diluted (in shares) | 192 | 186 | 166 | 151 | 106 | |
| Unrealized gain on available-for-sale securities | 37,000 | 286,000 | 2 | −2 | — | |
| Comprehensive loss | −33 | −70 | −71 | −72 | −76 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 18 | 36 | 26 | 31 | 109 | |
| Investments in marketable securities, current | 73 | 86 | 100 | 116 | 46 | |
| Accounts receivable | 1 | 2 | 2 | 1 | 899,000 | |
| Prepaid expenses and other current assets | 2 | 2 | 4 | 3 | 4 | |
| Total current assets | 94 | 127 | 132 | 151 | 161 | |
| Property and equipment, net of accumulated depreciation and impairment | 32,000 | 3 | 5 | 5 | 6 | |
| Investments in marketable securities, non-current | 0 | 0 | 6 | 37 | 36 | |
| Right of use asset | 0 | 1 | 1 | 2 | 2 | |
| Other non-current assets | 130,000 | 34,000 | 0 | 103,000 | 61,000 | |
| Total assets | 95 | 132 | 144 | 195 | 204 | |
| Accounts payable and accrued liabilities | 5 | 8 | 10 | 16 | 11 | |
| Deferred license revenue, current | 0 | 8 | 12 | 16 | 0 | |
| Lease liability, current | 547,000 | 483,000 | 425,000 | 372,000 | 383,000 | |
| Total current liabilities | 6 | 16 | 22 | 33 | 11 | |
| Liability related to sale of future royalties | 3 | 5 | 7 | 10 | 16 | |
| Deferred license revenue, non-current | 0 | 3 | 0 | 6 | 0 | |
| Contingent consideration | 8 | 10 | 8 | 8 | 5 | |
| Lease liability, non-current | 199,000 | 806,000 | 1 | 2 | 2 | |
| Total liabilities | 18 | 34 | 38 | 59 | 35 | |
| Issued and outstanding: 192,531,225 and 189,963,492 as of December 31, 2025 and 2024, respectively. | 1,421 | 1,410 | 1,350 | 1,319 | 1,287 | |
| Additional paid-in capital | 83 | 82 | 81 | 72 | 65 | |
| Deficit | −1,380 | −1,347 | −1,277 | −1,204 | −1,134 | |
| Accumulated other comprehensive loss | −48 | −48 | −48 | −50 | −48 | |
| Total stockholders' equity | 77 | 97 | 106 | 137 | 169 | |
| Total liabilities and stockholders' equity | 95 | 132 | 144 | 195 | 204 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation and amortization | 400,000 | 1 | 1 | 1 | 2 | |
| Stock-based compensation expense | 7 | 9 | 9 | 7 | 6 | |
| Non-cash royalty revenue | −1 | −2 | −4 | −8 | −6 | |
| Non-cash interest expense | 95,000 | 127,000 | 455,000 | 2 | 3 | |
| Restructuring, Settlement and Impairment Provisions | 3 | 167,000 | 0 | — | — | |
| Net accretion of investments in marketable securities | −2 | −3 | −2 | −54,000 | 999,000 | |
| Accounts receivable | 1 | −633,000 | −424,000 | −453,000 | 413,000 | |
| Prepaid expenses and other assets | 2 | 2 | −943,000 | 2 | −1 | |
| Accounts payable and accrued liabilities | −2 | −3 | −6 | 5 | 2 | |
| Change in deferred license revenue | −10 | −1 | −11 | 22 | 0 | |
| Other liabilities | −557,000 | −430,000 | −444,000 | −405,000 | −374,000 | |
| Net cash used in operating activities | −40 | −65 | −86 | −35 | −68 | |
| Purchase of investments in marketable securities | −140 | −142 | −81 | −130 | −82 | |
| Disposition of investments in marketable securities | 155 | 165 | 132 | 56 | 70 | |
| Proceeds from sale of property and equipment | 364,000 | 0 | 20,000 | 0 | — | |
| Acquisition of property and equipment | 0 | −182,000 | −1 | −512,000 | −809,000 | |
| Net cash provided by investing activities | 16 | 23 | 51 | −75 | −13 | |
| Issuance of common shares pursuant to the Open Market Sale Agreement | 0 | 44 | 30 | 20 | 135 | |
| Issuance of common shares pursuant to exercise of stock options | 6 | 7 | 260,000 | 122,000 | 2 | |
| Issuance of common shares pursuant to ESPP | 181,000 | 396,000 | 535,000 | 395,000 | 461,000 | |
| Net cash provided by financing activities | 6 | 52 | 31 | 32 | 137 | |
| Effect of foreign exchange rate changes on cash and cash equivalents | 14,000 | −49,000 | 25,000 | −22,000 | 5,000 | |
| (Decrease) / increase in cash and cash equivalents | −18 | 10 | −4 | −79 | 57 |