ADC Therapeutics SA
Business
ADC Therapeutics SA is a commercial-stage biotechnology company that develops and commercializes antibody drug conjugates (ADCs) for cancer treatment. It offers proprietary ADC products and investigational candidates, including ZYNLONTA (loncastuximab tesirine) and pipeline ADCs utilizing PBD and exatecan payloads, novel linkers and conjugation chemistries. The company’s key activities span hematology programs, solid tumor research programs, clinical development and CMC oversight, and collaborations and licensing arrangements. ADC Therapeutics distributes and commercializes products directly in the United States and through strategic partners, joint ventures and licensees across Europe, Asia and other global markets.
Summary from filing dated 2025-03-27
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 |
|---|---|---|---|---|---|
| Total revenue, net | 81 | 71 | 70 | 210 | |
| Cost of product sales | −6 | −6 | −3 | −3 | |
| Research and development | −104 | −110 | −127 | −186 | |
| Selling and marketing | −43 | −44 | −57 | −69 | |
| General and administrative | −37 | −42 | −48 | −74 | |
| Restructuring, impairment and other related costs | −13 | 0 | — | — | |
| Total operating expense | −203 | −201 | −236 | −333 | |
| Loss from operations | −121 | −131 | −166 | −123 | |
| Interest income | 9 | 12 | 11 | 3 | |
| Interest expense | −52 | −50 | −46 | — | |
| Other, net | 23 | 12 | 6 | 53 | |
| Total other expense, net | −20 | −25 | −29 | −23 | |
| Loss before income taxes | −142 | −156 | −195 | −147 | |
| Income tax expense | −1 | −200,000 | −39 | −227,000 | |
| Loss before equity in net losses of joint venture | −143 | −156 | −235 | −147 | |
| Equity in net losses of joint venture | 0 | −2 | 6 | 10 | |
| Net loss | −143 | −158 | −240 | −157 | |
| Net loss per share, basic (in dollars per share) | −1.12 | −1.62 | −2.94 | −2.01 | |
| Net loss per share, diluted (in dollars per share) | −1.12 | −1.62 | −2.94 | −2.01 | |
| Weighted average shares outstanding, basic (in shares) | 127 | 97 | 82 | 78 | |
| Weighted average shares outstanding, diluted (in shares) | 127 | 97 | 82 | 78 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 261 | 251 | 279 | 326 | — | |
| Accounts receivable, net | 29 | 20 | 25 | 73 | — | |
| Inventory | 4 | 2 | 16 | 12 | — | |
| Prepaid expenses | 6 | 8 | 10 | 23 | — | |
| Other current assets | 6 | 9 | 6 | — | — | |
| Total current assets | 306 | 291 | 336 | 435 | — | |
| Inventory, long-term | 14 | 16 | — | — | — | |
| Property and equipment, net | 0 | 5 | 6 | 3 | — | |
| Operating lease right-of-use assets | 1 | 8 | 11 | 7 | — | |
| Other long-term assets | 1 | 1 | 711,000 | 902,000 | — | |
| Total assets | 323 | 322 | 355 | 491 | — | |
| Accounts payable | 9 | 18 | 16 | 12 | — | |
| Accrued expenses and other current liabilities | 58 | 62 | 52 | 68 | — | |
| Senior secured term loans, current portion | 3 | 0 | — | — | — | |
| Total current liabilities | 70 | 80 | 68 | 82 | — | |
| Deferred royalty obligation, long-term | 323 | 320 | 304 | 212 | — | |
| Senior secured term loans, long-term | 112 | 114 | 113 | 110 | — | |
| Operating lease liabilities, long-term | 1 | 8 | 10 | 7 | — | |
| Other long-term liabilities | 3 | 2 | 9 | 838,000 | — | |
| Total liabilities | 509 | 525 | 503 | 411 | — | |
| Commitments and contingencies (Note 14) | — | — | — | — | — | |
| Common shares, at CHF 0.08 par value | 11 | 8 | 7 | 7 | — | |
| Additional paid-in capital | 1,440 | 1,284 | 1,181 | 1,166 | — | |
| Treasury shares | −205,000 | −220,000 | −541,000 | −679,000 | — | |
| Accumulated other comprehensive loss | −517,000 | −1 | −93,000 | 2 | — | |
| Accumulated deficit | −1,636 | −1,493 | −1,335 | −1,095 | — | |
| Total shareholders (deficit) equity | −186 | −203 | −148 | 79 | 154 | |
| Total liabilities and shareholders (deficit) equity | 323 | 322 | 355 | 491 | — |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 |
|---|---|---|---|---|---|
| Share-based compensation expense | 7 | 7 | 13 | 49 | |
| Accretion expense of deferred royalty obligation | 29 | 28 | 19 | 12 | |
| Cumulative catch-up adjustment, deferred royalty obligation | −22 | −11 | −5 | −15 | |
| Write-downs of inventory | 2 | 2 | 2 | 2 | |
| Depreciation | 705,000 | 1 | 1 | 1 | |
| Amortization of operating lease right-of-use assets | 1 | 2 | 2 | 1 | |
| Amortization of debt discount, senior secured term loan | 2 | 902,000 | — | — | |
| Impairment of long-lived assets and prepaid expenses and other related costs | 7 | 0 | — | — | |
| Other | 304,000 | −669,000 | 52,000 | 91,000 | |
| Accounts receivable, net | −9 | 5 | 48 | −43 | |
| Inventory | −2 | −4 | −6 | −10 | |
| Prepaid expenses and other current assets | 5 | −1 | 7 | −11 | |
| Other long-term assets | −46,000 | −456,000 | 200,000 | −210,000 | |
| Accounts payable | −9 | 2 | 3 | 310,000 | |
| Accrued expenses and other current liabilities | −7 | 11 | −14 | 16 | |
| Operating lease liabilities | −3 | −2 | −2 | −1 | |
| Other long-term liabilities | −410,000 | −7 | 7 | 0 | |
| Net cash used in operating activities | −141 | −124 | −119 | −138 | |
| Payment for purchases of property and equipment | −264,000 | −867,000 | −3 | −687,000 | |
| Proceeds from the sale of equipment | 659,000 | 0 | — | — | |
| Net cash provided by (used in) investing activities | 395,000 | −867,000 | −3 | −687,000 | |
| Proceeds from sale of common shares, net of transaction costs | 86 | 61 | 0 | — | |
| Proceeds from Pre-Funded Warrants, net of transaction costs | 65 | 37 | 0 | — | |
| Proceeds from share issuance under stock purchase plan | 271,000 | 558,000 | 773,000 | 0 | |
| Proceeds from the exercise of options | 534,000 | 228,000 | 0 | — | |
| Taxes paid related to net settled equity awards | −2 | −1 | 0 | −1 | |
| Net cash provided by financing activities | 151 | 97 | 74 | −897,000 | |
| Net decrease in cash and cash equivalents | 10 | −28 | −48 | −140 | |
| Exchange (losses)/gains on cash and cash equivalents | 305,000 | −83,000 | 184,000 | −208,000 | |
| Interest paid | 14 | 16 | 15 | 10 | |
| Interest received | 9 | 14 | 10 | 2 | |
| Payments made under royalty financing transaction | −6 | −5 | −9 | −11 | |
| Transaction costs recorded in Accounts payable and other current liabilities and Other long-term liabilities | 837,000 | 0 | — | — |