Aldeyra Therapeutics, Inc.
Business
Aldeyra Therapeutics, Inc. is a biotechnology company focused on discovering and developing innovative therapies that treat immune-mediated and metabolic diseases by modulating reactive aldehyde species (RASP) to influence multiple protein systems. Its main product candidates include reproxalap, a topical RASP modulator for dry eye disease and allergic conjunctivitis, ADX‑2191, an intravitreal methotrexate formulation for retinitis pigmentosa, and multiple preclinical and clinical RASP modulators such as ADX‑629, ADX‑248, ADX‑743, ADX‑631, and ADX‑246. The company organizes operations around a RASP modulator platform with activities in discovery, preclinical research, clinical development, regulatory filings, and plans for partnered commercialization. Aldeyra conducts clinical trials across multiple sites, relies on third‑party contract manufacturers, and pursues commercialization through collaborations and licensing arrangements both in the United States and internationally.
Summary from filing dated 2025-02-28
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 26 | 48 | 29 | 47 | 45 | |
| General and administrative | 10 | 12 | 13 | 15 | 11 | |
| Loss from operations | −35 | −60 | −43 | −63 | −56 | |
| Interest income | 3 | 6 | 7 | 2 | 185,363 | |
| Interest expense | −2 | −2 | −2 | — | — | |
| Total other income, net | 1 | 4 | 5 | 655,351 | −2 | |
| Net loss | −34 | −56 | −38 | −62 | −58 | |
| Net loss per share - basic | −0.56 | −0.94 | −0.64 | −1.06 | −1.07 | |
| Net loss per share - diluted | −0.56 | −0.94 | −0.64 | −1.06 | −1.07 | |
| Weighted average common shares outstanding - basic | 60 | 59 | 59 | 58 | 54 | |
| Weighted average common shares outstanding - diluted | 60 | 59 | 59 | 58 | 54 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 70 | 55 | 143 | 144 | 105 | |
| Marketable securities | 0 | 47 | 0 | 30 | 0 | |
| Prepaid expenses and other current assets | 2 | 3 | 5 | 7 | 3 | |
| Total current assets | 72 | 104 | 148 | 181 | 233 | |
| Deferred offering costs | 0 | 267,261 | 0 | — | — | |
| Right-of-use assets | 275,861 | 266,955 | 510,814 | 249,265 | 351,863 | |
| Total assets | 72 | 105 | 148 | 181 | 233 | |
| Accounts payable | 158,461 | 180,453 | 1 | 133,625 | 1 | |
| Accrued expenses | 6 | 12 | 6 | 14 | 11 | |
| Current portion of debt | 15 | 31,372 | 15 | 911,763 | — | |
| Operating lease liabilities | 280,537 | 271,631 | 239,183 | 249,265 | 229,607 | |
| Deferred collaboration revenue | 6 | 6 | 0 | — | — | |
| Total current liabilities | 28 | 19 | 22 | 15 | 12 | |
| Long-term debt, net of current portion | 0 | 15 | 0 | 15 | 16 | |
| Total liabilities | 28 | 34 | 29 | 30 | 27 | |
| Commitments and contingencies (Notes 3, 9, & 13) | — | — | — | — | — | |
| Preferred stock, $0.001 par value, 15,000,000 shares authorized, none issued and outstanding | 0 | 0 | 0 | 0 | 0 | |
| Common stock, voting, $0.001 par value; 150,000,000 authorized and 59,648,278 and 59,195,951 shares issued and outstanding, respectively | 60,163 | 59,648 | 59,196 | 58,560 | 58,081 | |
| Additional paid-in capital | 528 | 521 | 514 | 508 | 500 | |
| Accumulated other comprehensive income | 0 | 37,442 | 0 | −103,938 | 0 | |
| Accumulated deficit | −484 | −450 | −394 | −357 | −295 | |
| Total stockholders equity | 44 | 71 | 120 | 151 | 206 | |
| Total liabilities and stockholders equity | 72 | 105 | 148 | 181 | 233 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −34 | −56 | −38 | −62 | −58 | |
| Stock-based compensation | 6 | 8 | 6 | 8 | 7 | |
| Non-cash interest expense | 218,260 | 177,326 | 354,193 | 331,150 | 409,471 | |
| Net amortization of premium on marketable securities | −1 | −2 | −14,542 | −47,245 | 0 | |
| Depreciation and amortization expense | 251,993 | 249,623 | 262,780 | 258,707 | 264,180 | |
| Write-off of deferred offering costs | 267,261 | 0 | — | — | — | |
| Prepaid expenses and other current assets | 1 | 2 | 2 | −4 | 2 | |
| Accounts payable | −21,992 | −1 | 1 | −886,077 | 638,064 | |
| Accrued expenses and other liabilities | −6 | 5 | −8 | 1 | 5 | |
| Net cash used in operating activities | −33 | −43 | −30 | −57 | −43 | |
| Purchases of marketable securities | −40 | −97 | 0 | −93 | 0 | |
| Maturities of marketable securities | 88 | 52 | 30 | 63 | 0 | |
| Net cash provided by (used in) investing activities | 48 | −45 | 30 | −30 | −7,806 | |
| Issuance costs | 0 | −267,261 | 0 | — | — | |
| Proceeds from exercise of stock options | 1 | 350,279 | 194,129 | 1 | 5 | |
| Proceeds from employee stock purchase plan | 19,616 | 38,060 | 111,102 | 96,665 | 61,529 | |
| Debt end of term charge paid in cash | 0 | −292,500 | −1 | 0 | — | |
| Net cash provided by (used in) financing activities | 1 | −171,422 | −1 | 1 | 194 | |
| NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS | 16 | −88 | −2 | −85 | 152 | |
| Cash paid during the period for interest | 2 | 2 | 2 | 1 | 1 |