ALX ONCOLOGY HOLDINGS INC
Business
ALX ONCOLOGY HOLDINGS INC is a clinical-stage immuno-oncology company developing therapies that block the CD47 immune checkpoint to engage macrophages and dendritic cells and bridge innate and adaptive anti-tumor immunity. Its main product candidate is evorpacept, a high-affinity SIRPα-based fusion protein with an inactivated Fc domain designed for combination use, alongside early programs including a TLR9-conjugate (ALTA-002) and an ADC program (ALX2004). The company operates through clinical development programs, strategic collaborations and investigator-sponsored trials and relies on contract manufacturers for supply. It conducts multinational clinical trials and intends to commercialize products in the United States and other regions, using partners and third-party distribution channels as needed.
Summary from filing dated 2025-03-06
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 77 | 116 | 142 | 98 | 60 | |
| General and administrative | 24 | 26 | 28 | 29 | 23 | |
| Impairment charge | 3 | — | — | — | — | |
| Total operating expenses | 104 | 142 | 170 | 127 | 84 | |
| Loss from operations | −104 | −142 | −170 | −127 | −84 | |
| Interest income | 4 | 9 | 11 | 4 | 91,000 | |
| Interest expense | −2 | −2 | −2 | −238,000 | −13,000 | |
| Other income (expense), net | −36,000 | −20,000 | 389,000 | −22,000 | −7,000 | |
| Loss before income taxes | −102 | −135 | −161 | −123 | −83 | |
| Income tax provision | 0 | 0 | 0 | −64,000 | 21,000 | |
| Net loss | −102 | −135 | −161 | −123 | −83 | |
| Net loss per share, basic | −1.9 | −2.58 | −3.74 | −3.03 | −2.07 | |
| Net loss per share, diluted | −1.9 | −2.58 | −3.74 | −3.03 | −2.07 | |
| Weighted-average shares of common stock used to compute net loss per share, basic | 54 | 52 | 43 | 41 | 40 | |
| Weighted-average shares of common stock used to compute net loss per share, diluted | 54 | 52 | 43 | 41 | 40 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 16 | 18 | 22 | 49 | 364 | |
| Short-term investments | 28 | 110 | 160 | 217 | — | |
| Prepaid expenses and other current assets | 6 | 7 | 6 | 5 | 3 | |
| Total current assets | 51 | 134 | 189 | 271 | 367 | |
| Property and equipment, net | 1 | 3 | 4 | 4 | 897,000 | |
| Long-term investments | 3 | 4 | 35 | 17 | — | |
| Other assets | 4 | 7 | 15 | 15 | 12 | |
| Total assets | 59 | 148 | 243 | 306 | 380 | |
| Accounts payable | 5 | 4 | 9 | 8 | 4 | |
| Payable and accrued liabilities due to related party | 0 | 149,000 | 543,000 | 2 | — | |
| Term loan, current | 5 | 435,000 | — | — | — | |
| Accrued expenses and other current liabilities | 14 | 13 | 27 | 19 | 10 | |
| Total current liabilities | 25 | 19 | 36 | 28 | 15 | |
| Term loan, non-current, net | 5 | 9 | 10 | 9 | — | |
| Other non-current liabilities | 4 | 6 | 7 | 5 | 2 | |
| Total liabilities | 33 | 34 | 53 | 43 | 17 | |
| Commitments and contingencies (Note 13) | — | — | — | — | — | |
| Common stock, $0.001 par value; 1,000,000,000 shares authorized as of December 31, 2025 and December 31, 2024; 54,388,022 and 53,052,912 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively | 54,000 | 53,000 | 50,000 | 41,000 | 41,000 | |
| Additional paid-in capital | 749 | 734 | 676 | 590 | 565 | |
| Accumulated other comprehensive income | 28,000 | 275,000 | 256,000 | −845,000 | — | |
| Accumulated deficit | −723 | −621 | −486 | −325 | −202 | |
| Total stockholders equity | 26 | 114 | 190 | 263 | 363 | |
| Total liabilities and stockholders equity | 59 | 148 | 243 | 306 | 380 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −102 | −135 | −161 | −123 | −83 | |
| Stock-based compensation | 13 | 27 | 26 | 24 | 14 | |
| Depreciation and amortization | 706,000 | 872,000 | 836,000 | 342,000 | 51,000 | |
| Non-cash lease costs | 2 | 2 | 1 | 1 | 685,000 | |
| Net accretion of discounts on investments | −1 | −5 | −6 | −940,000 | — | |
| Accretion of term loan discount and issuance costs | 280,000 | 265,000 | 250,000 | 44,000 | — | |
| Loss on disposal of fixed asset | — | 10,000 | — | — | — | |
| Prepaid expenses and other current assets | 658,000 | −692,000 | −1 | −1 | −2 | |
| Other assets | −686,000 | 7 | 1 | 750,000 | −10 | |
| Accounts payable | 421,000 | −4 | 458,000 | 5 | 3 | |
| Payable and accrued liabilities due to related party | −149,000 | −394,000 | −1 | 20,000 | 1 | |
| Accrued expenses and other current liabilities | 2 | −13 | 11 | 7 | 3 | |
| Other non-current liabilities | −2 | −2 | −2 | −977,000 | −698,000 | |
| Net cash used in operating activities | −84 | −122 | −130 | −89 | −68 | |
| Purchase of investments | −52 | −107 | −247 | −377 | — | |
| Maturities of investments | 134 | 194 | 293 | 143 | — | |
| Purchase of property and equipment | −212,000 | −447,000 | −1 | −1 | −666,000 | |
| Net cash provided by investing activities | 83 | 86 | 45 | −235 | −5 | |
| Proceeds from equity offerings, net of underwriter discounts ($3,795 thousand) and issuance costs ($567 thousand) | — | — | 59 | — | — | |
| Proceeds from ATM offering, net of commissions | 2 | 30 | — | — | — | |
| Proceeds from exercise of stock options under equity incentive plan | 14,000 | 2 | 269,000 | 567,000 | 3 | |
| Proceeds from issuance of common stock under employee stock purchase plan | 24,000 | 351,000 | 523,000 | 336,000 | 202,000 | |
| Principal payments on finance leases | −929,000 | −827,000 | −388,000 | −388,000 | −281,000 | |
| Principal payments on term loan | −435,000 | — | — | — | — | |
| Net cash provided by financing activities | 362,000 | 31 | 59 | 10 | 2 | |
| Net (decrease) in cash, cash equivalents and restricted cash | −1 | −5 | −26 | −315 | −71 | |
| Cash paid for interest | 1 | 1 | 1 | 103,000 | 11,000 | |
| Purchase of property and equipment in accounts payable and accrued expenses | 962,000 | 1 | 1 | 2 | 237,000 | |
| Right-of-use asset (modified) acquired under finance leases | −182,000 | 1 | 3 | — | — |