ARROWHEAD PHARMACEUTICALS, INC.
Business
ARROWHEAD PHARMACEUTICALS, INC. develops medicines that treat intractable diseases by silencing disease-causing genes using RNA interference (RNAi) technologies. It designs and delivers siRNA therapeutics and related RNA chemistries via its proprietary TRiM platform, with an approved siRNA product and multiple clinical-stage and discovery-stage candidates. The company organizes activities across discovery, preclinical and clinical development, manufacturing and commercial operations, and enters licensing and collaboration agreements for partnered programs. It pursues regulatory approvals and clinical trials across the United States, the European Union and other international markets while leveraging partner commercialization channels worldwide.
Summary from filing dated 2025-11-25
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-09-30 | FY 2024 2024-09-30 | FY 2023 2023-09-30 | FY 2022 2022-09-30 | FY 2021 2021-09-30 |
|---|---|---|---|---|---|---|
| Revenue | 829 | 4 | 241 | 243 | 138 | |
| Research and development | 607 | 506 | 353 | — | — | |
| General and administrative | 124 | 99 | 93 | 124 | 81 | |
| Total operating expenses | 731 | 605 | 446 | 422 | 287 | |
| Operating income (loss) | 98 | −601 | −205 | −179 | −149 | |
| Interest income | 37 | 23 | 15 | 5 | 6 | |
| Interest expense | −89 | −32 | −18 | 0 | — | |
| Other, net | 5 | −2 | 2 | 765,000 | 2 | |
| Total other expense | −47 | −11 | −1 | 6 | 8 | |
| Income (loss) before income tax expense and noncontrolling interest | 52 | −612 | −206 | −173 | −141 | |
| Income tax expense (benefit) | 21 | −3 | 3 | 4 | 2,000 | |
| Net income (loss) including noncontrolling interest | 30 | −610 | −209 | −176 | −141 | |
| Net income (loss) attributable to noncontrolling interest, net of tax | 32 | −10 | −4 | −431,000 | 0 | |
| Net loss attributable to Arrowhead Pharmaceuticals, Inc. | −2 | −599 | −205 | −176 | −141 | |
| Basic (in dollars per share) | −0.01 | −5 | −1.92 | −1.67 | −1.36 | |
| Diluted (in dollars per share) | −0.01 | −5 | −1.92 | −1.67 | −1.36 | |
| Basic (in shares) | 134 | 120 | 107 | 105 | 104 | |
| Diluted (in shares) | 134 | 120 | 107 | 105 | 104 | |
| Unrealized gains (losses) on available-for-sale securities | 2 | 4 | −3 | 0 | 0 | |
| Foreign currency translation adjustments | −432,000 | 4 | −122,000 | −67,000 | −87,000 | |
| Comprehensive income (loss) attributed to noncontrolling interest | 32 | −10 | −4 | — | — | |
| Other comprehensive income (loss) | 32 | −602 | −212 | −177 | −141 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-09-30 | FY 2024 2024-09-30 | FY 2023 2023-09-30 | FY 2022 2022-09-30 | FY 2021 2021-09-30 |
|---|---|---|---|---|---|---|
| Cash, cash equivalents and restricted cash | 227 | 103 | 111 | 108 | 184 | |
| Accounts receivable | 7 | 0 | 0 | 1 | 10 | |
| Available-for-sale securities, at fair value | 693 | 578 | 293 | 0 | — | |
| Prepaid expenses | 11 | 10 | 9 | 7 | 4 | |
| Other current assets | 14 | 5 | 4 | 20 | 2 | |
| Total current assets | 951 | 695 | 416 | 405 | 385 | |
| Property, plant and equipment, net | 383 | 386 | 290 | 110 | 49 | |
| Intangible assets, net | 7 | 9 | 10 | 12 | 14 | |
| Right-of-use assets | 44 | 45 | 45 | 58 | 17 | |
| Other assets | 1 | 4 | 3 | 218,000 | 272,000 | |
| Total Assets | 1,385 | 1,140 | 766 | 692 | 710 | |
| Accounts payable | 18 | 11 | 36 | 3 | 9 | |
| Accrued expenses | 90 | 63 | 40 | 47 | 14 | |
| Accrued payroll and benefits | 27 | 22 | 18 | 12 | 10 | |
| Lease liabilities | 7 | 6 | 11 | 3 | 2 | |
| Deferred revenue | 2 | 0 | 866,000 | 74 | 111 | |
| Credit facility | 40 | 0 | — | — | — | |
| Other liabilities | 11 | 432,000 | 435,000 | 0 | — | |
| Total current liabilities | 195 | 103 | 105 | 139 | 147 | |
| Lease liabilities, net of current portion | 104 | 111 | 105 | 79 | 23 | |
| Liability related to the sale of future royalties | 367 | 341 | 268 | 0 | — | |
| Credit facility, net of current portion | 215 | 393 | 0 | — | — | |
| Total long-term liabilities | 686 | 846 | 373 | 135 | 155 | |
| Commitments and contingencies (Note 7) | — | — | — | — | — | |
| Common stock, $0.001 par value: Authorized 290,000 shares; issued and outstanding 135,702 and 124,376 shares at September 30, 2025 and 2024, respectively | 231,000 | 217,000 | 200,000 | 198,000 | 197,000 | |
| Additional paid-in capital | 2,140 | 1,806 | 1,300 | 1,219 | 1,053 | |
| Accumulated other comprehensive income | 6 | 5 | −3 | −136,000 | −69,000 | |
| Accumulated deficit | −1,627 | −1,626 | −1,026 | −821 | −645 | |
| Treasury stock; at cost; 2,661 and 0 shares of common stock at September 30, 2025 and 2024, respectively | −53 | 0 | — | — | — | |
| Total Arrowhead Pharmaceuticals, Inc. stockholders' equity | 466 | 185 | 271 | 399 | 409 | |
| Noncontrolling interest | 37 | 6 | 16 | 20 | 0 | |
| Total noncontrolling interest and stockholders' equity | 503 | 191 | 287 | 418 | 409 | |
| Total Liabilities, Noncontrolling Interest and Stockholders' Equity | 1,385 | 1,140 | 766 | 692 | 710 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-09-30 | FY 2024 2024-09-30 | FY 2023 2023-09-30 | FY 2022 2022-09-30 | FY 2021 2021-09-30 |
|---|---|---|---|---|---|---|
| Stock-based compensation | 63 | 74 | 78 | 121 | 77 | |
| Depreciation and amortization | 24 | 19 | 12 | 10 | 8 | |
| Accretion of note premiums/discounts | −6 | −3 | −2 | 3 | 266,000 | |
| Non-cash interest expense on liability related to the sale of future royalties | 26 | 23 | 18 | — | — | |
| Non-cash interest expense on credit facility | 63 | 9 | 0 | 0 | — | |
| Non-cash gain on treasury stock received | −3 | 0 | 0 | — | — | |
| Realized loss on investments | 0 | 80,000 | 0 | 4 | — | |
| Accounts receivable | −57 | 0 | 1 | 9 | −9 | |
| Prepaid expenses and other current assets | −10 | −2 | 12 | −19 | −360,000 | |
| Accounts payable | 6 | −6 | 33 | −7 | 3 | |
| Accrued expenses | 41 | 32 | −15 | 18 | 10 | |
| Deferred revenue | 2 | −866,000 | −129 | −113 | 223 | |
| Operating lease, net | −5 | 2 | 47 | 13 | 3 | |
| Other | 3 | −1 | 0 | — | — | |
| Net cash provided by (used in) operating activities | 180 | −463 | −154 | −136 | 171 | |
| Purchases of property, plant and equipment | −23 | −141 | −177 | −53 | −24 | |
| Purchases of investments | −796 | −721 | −246 | −223 | −241 | |
| Proceeds from sales and maturities of investments | 690 | 442 | 327 | 271 | 123 | |
| Net cash used in investing activities | −129 | −420 | −96 | −5 | −142 | |
| Proceeds from the exercises of stock options | 4 | 2 | 3 | 5 | 11 | |
| Proceeds from the issuance of common stock, net of offering costs | 241 | 429 | 0 | 0 | 0 | |
| Proceeds from the sale of future royalties | 0 | 50 | 250 | 0 | 0 | |
| Proceeds from the issuance of warrants | 25 | 0 | 0 | — | — | |
| Payment of debt issuance costs | −5 | −3 | 0 | 0 | — | |
| Proceeds from credit facility | 0 | 392 | 0 | 0 | — | |
| Repayments of credit facility | −202 | 0 | 0 | — | — | |
| Proceeds from Visirna credit agreement | 10 | 0 | 0 | — | — | |
| Net cash provided by financing activities | 74 | 871 | 253 | 65 | 11 | |
| Net increase (decrease) in cash, cash equivalents and restricted cash | 124 | −12 | 3 | −76 | 41 | |
| Effect of exchange rate on cash, cash equivalents and restricted cash | −401,000 | 4 | −122,000 | −67,000 | −88,000 | |
| Interest paid | −19,000 | 0 | 0 | 0 | 0 | |
| Income taxes (refund) paid | 814,000 | −4 | 0 | −2,000 | −2,000 | |
| Treasury stock received to settle accounts receivable | 50 | 0 | 0 | — | — | |
| Capital expenditures included in accrued expenses | 277,000 | 4 | 14 | 18 | — |