ASSEMBLY BIOSCIENCES, INC.
Business
ASSEMBLY BIOSCIENCES, INC. is a biotechnology company developing novel antiviral therapeutics targeting serious viral diseases. It develops clinical-stage product candidates including helicase-primase inhibitors for recurrent genital herpes, an oral hepatitis delta virus entry inhibitor, a next-generation capsid assembly modulator for hepatitis B, and a broad-spectrum non-nucleoside polymerase inhibitor for transplant-associated herpesviruses. The company organizes activities across discovery, preclinical and clinical development programs and collaborates with partners such as Gilead for development and commercialization. It conducts clinical studies globally and relies on CROs and third-party manufacturers for development, supply and distribution.
Summary from filing dated 2025-03-20
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Collaboration revenue from a related party | 72 | 29 | — | — | — | |
| Research and development | 65 | 56 | 49 | 70 | 69 | |
| General and administrative | 20 | 18 | 23 | 24 | 29 | |
| Total operating expenses | 84 | 74 | 72 | 94 | 139 | |
| Loss from operations | −12 | −45 | −65 | −94 | −133 | |
| Interest and other income, net | 6 | 6 | 3 | 1 | 302,000 | |
| Total other income | 6 | 6 | 3 | 1 | 302,000 | |
| Loss before income taxes | −6 | −40 | −61 | −93 | −132 | |
| Income tax expense | 0 | 330,000 | 33,000 | 0 | 3 | |
| Net loss | −6 | −40 | −61 | −93 | −130 | |
| Unrealized gain (loss) on marketable securities | 170,000 | −130,000 | 722,000 | −384,000 | −149,000 | |
| Comprehensive loss | −6 | −40 | −61 | −93 | −130 | |
| Net loss per share - basic | −0.55 | −6.69 | −13.38 | −23.08 | −3 | |
| Net loss per share - diluted | −0.55 | −6.69 | −13.38 | −23.08 | −3 | |
| Weighted average common shares outstanding, basic | 11 | 6 | 5 | 4 | 43 | |
| Weighted average common shares outstanding, diluted | 11 | 6 | 5 | 4 | 43 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 58 | 38 | 20 | 52 | 46 | |
| Marketable securities | 190 | 74 | 110 | 39 | 101 | |
| Accounts receivable from collaboration with a related party | 974,000 | 0 | 43,000 | 944,000 | 336,000 | |
| Prepaid expenses and other current assets | 5 | 3 | 3 | 4 | 7 | |
| Total current assets | 255 | 116 | 134 | 97 | 154 | |
| Property and equipment, net | 221,000 | 284,000 | 385,000 | 743,000 | 1 | |
| Operating lease right-of-use (ROU) assets | 3 | 3 | 2 | 3 | 6 | |
| Other assets | 312,000 | 312,000 | 312,000 | 889,000 | 2 | |
| Total assets | 258 | 119 | 137 | 102 | 191 | |
| Accounts payable | 1 | 585,000 | 461,000 | 2 | 3 | |
| Accrued research and development expenses | 2 | 2 | 885,000 | 3 | 3 | |
| Other accrued expenses | 8 | 7 | 6 | 7 | 7 | |
| Deferred revenue from a related party - short-term | 37 | 38 | 31 | — | — | |
| Operating lease liabilities - short-term | 569,000 | 461,000 | 1 | 3 | 3 | |
| Total current liabilities | 49 | 48 | 39 | 16 | 16 | |
| Deferred revenue from a related party - long-term | 0 | 35 | 55 | 3 | 3 | |
| Operating lease liabilities - long-term | 2 | 3 | 1 | 101,000 | 3 | |
| Total liabilities | 51 | 86 | 96 | 19 | 22 | |
| Commitments and contingencies | — | — | — | — | — | |
| Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding | — | — | — | — | — | |
| Common stock, $0.001 par value; 150,000,000 shares authorized as of December 31, 2025 and December 31, 2024; 15,855,329 and 7,457,240 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively | 16,000 | 7,000 | 5,000 | 4,000 | 48,000 | |
| Additional paid-in capital | 1,039 | 859 | 827 | 808 | 801 | |
| Accumulated other comprehensive loss | −41,000 | −211,000 | −81,000 | −803,000 | −419,000 | |
| Accumulated deficit | −832 | −826 | −786 | −725 | −631 | |
| Total stockholders' equity | 207 | 33 | 41 | 83 | 169 | |
| Total liabilities and stockholders' equity | 258 | 119 | 137 | 102 | 191 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −6 | −40 | −61 | −93 | −130 | |
| Depreciation and amortization | 129,000 | 129,000 | 450,000 | 498,000 | 466,000 | |
| Stock-based compensation | 5 | 3 | 5 | 7 | 5 | |
| Net accretion of investments in marketable debt securities | −2 | −4 | −2 | 155,000 | — | |
| Non-cash rent expense | 851,000 | 1 | 4 | 4 | 4 | |
| Realized gain on investments in marketable debt securities | −3,000 | 0 | — | — | — | |
| Accounts receivable from collaboration | −974,000 | 43,000 | 901,000 | −608,000 | 894,000 | |
| Prepaid expenses and other current assets | −2 | 73,000 | 916,000 | 1 | 1 | |
| Accounts payable | 586,000 | 124,000 | −2 | −166,000 | −2 | |
| Accrued research and development expenses | 114,000 | 1 | −2 | −278,000 | −1 | |
| Other accrued expenses | 887,000 | 1 | −2 | 458,000 | −5 | |
| Deferred revenue from a related party | −36 | −13 | 84 | 0 | −6 | |
| Operating lease liabilities | −751,000 | −1 | −4 | −4 | −4 | |
| Net cash used in operating activities | −41 | −51 | 23 | −84 | −93 | |
| Proceeds from maturities of marketable securities | 116 | 131 | 65 | 88 | 175 | |
| Purchases of marketable securities | −230 | −91 | −134 | −28 | −160 | |
| Purchases of property and equipment | −66,000 | −28,000 | −255,000 | −102,000 | −3 | |
| Net cash (used in) provided by investing activities | −113 | 40 | −69 | 91 | 27 | |
| Proceeds from the issuance of common stock, pre-funded warrants and warrants in an underwritten offering, net of issuance costs | 124 | 0 | — | — | — | |
| Proceeds from the issuance of common stock and warrants in private placements to a related party, net of issuance costs | 43 | 18 | 9 | — | — | |
| Proceeds from the exercise of warrants | 6 | 0 | — | — | — | |
| Proceeds from the issuance of common stock under ATM equity offering program, net of issuance costs | 2 | 2 | 5 | 325,000 | 53 | |
| Proceeds from the issuance of common stock under ESPP | 725,000 | 150,000 | 129,000 | 289,000 | 258,000 | |
| Proceeds from the exercise of stock options | 125,000 | 5,000 | 0 | — | 0 | |
| Proceeds from the issuance of common stock and warrants in a registered direct offering, net of issuance costs | 0 | 10 | 0 | — | — | |
| Net cash provided by financing activities | 175 | 29 | 14 | 614,000 | 53 | |
| Net increase in cash and cash equivalents | 20 | 19 | −33 | 7 | −14 | |
| Operating lease liabilities arising from obtaining ROU assets | 0 | 2 | 2 | 171,000 | 126,000 |