Avalo Therapeutics, Inc.
Business
Avalo Therapeutics, Inc. is a clinical‑stage biotechnology company focused on treating immune dysregulation, principally developing anti‑inflammatory biologics. Its main product candidate is AVTX‑009, a humanized anti‑IL‑1β monoclonal antibody being evaluated in Phase 2 for hidradenitis suppurativa and planned for other chronic inflammatory indications, alongside several legacy and preclinical assets. The company’s activities are organized around clinical development, licensing/acquisition of assets, intellectual property management and potential out‑licensing. Clinical trials and potential commercialization efforts span the United States, Canada, multiple European countries, Australia and other international markets, with manufacturing and commercialization conducted via contract manufacturers and third‑party or partner arrangements.
Summary from filing dated 2025-03-20
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenues, net | 59,000 | 441,000 | 2 | 18 | 5 | |
| Cost of product sales | 0 | −366,000 | 1 | — | — | |
| Research and development | 50 | 24 | 14 | 31 | 60 | |
| Acquired in-process research and development | 0 | 28 | 0 | — | — | |
| General and administrative | 23 | 17 | 10 | 21 | 25 | |
| Total operating expenses | 73 | 69 | 29 | 55 | 88 | |
| Loss from operations | −73 | −69 | −27 | −37 | −82 | |
| Change in fair value of derivative liability | −10 | −3 | −720,000 | — | — | |
| Interest income, net | 4 | 3 | −3 | −4 | −2 | |
| Excess of initial warrant fair value over private placement proceeds | 0 | −79 | 0 | — | — | |
| Change in fair value of warrant liability | 0 | 122 | 0 | — | — | |
| Private placement transaction costs | 0 | −9 | 0 | — | — | |
| Total other (expense) income, net | −5 | 33 | −4 | −4 | −2 | |
| Loss before income taxes | −78 | −35 | −32 | −42 | — | |
| Income tax expense | 165,000 | 114,000 | 14,000 | 28,000 | −196,000 | |
| Net loss | −78 | −35 | −32 | −42 | −84 | |
| Net loss per share of common stock - basic (in dollars per share) | −5.84 | −7.94 | −113.58 | −1,063 | — | |
| Net loss per share of common stock - diluted (in dollars per share) | −5.84 | −20.91 | −113.58 | −1,063 | — | |
| Weighted average common shares outstanding - basic (in shares) | 13 | 4 | — | — | — | |
| Weighted average common shares outstanding - diluted (in shares) | 13 | 7 | — | — | — | |
| Unrealized income on investments, net | 68,000 | 0 | — | — | — | |
| Comprehensive loss | −78 | −35 | — | — | — |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 16 | 135 | 7 | 13 | 55 | |
| Short-term investments | 82 | 0 | — | — | — | |
| Prepaid expenses and other current assets | 7 | 4 | 843,000 | 1 | 2 | |
| Restricted cash, current portion | 37,000 | 19,000 | 1,000 | 15,000 | 51,000 | |
| Total current assets | 105 | 139 | 8 | 16 | 62 | |
| Property and equipment, net | 460,000 | 1 | 2 | 2 | 3 | |
| Goodwill | 11 | 11 | 11 | 14 | 14 | |
| Restricted cash, net of current portion | 210,000 | 131,000 | 131,000 | 131,000 | 227,000 | |
| Total assets | 116 | 151 | 21 | 33 | 80 | |
| Accounts payable | 137,000 | 283,000 | 446,000 | 3 | 3 | |
| Accrued expenses and other current liabilities | 13 | 6 | 4 | 13 | 17 | |
| Derivative liability, current | 0 | 360,000 | 0 | — | — | |
| Total current liabilities | 13 | 7 | 5 | 22 | 20 | |
| Royalty obligation | 2 | 2 | 2 | 2 | 2 | |
| Deferred tax liability, net | 434,000 | 270,000 | 155,000 | 141,000 | 113,000 | |
| Derivative liability, non-current | 18 | 8 | 6 | 5 | 0 | |
| Other long-term liabilities | 35,000 | 350,000 | 1 | 2 | 2 | |
| Total liabilities | 33 | 18 | 14 | 44 | 57 | |
| Temporary equity, values issued | 0 | 0 | 0 | 0 | — | |
| Common stock$0.001 par value; 200,000,000 shares authorized at December 31, 2025 and December 31, 2024; 18,512,757 and 10,471,934 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively | 18,000 | 10,000 | 1,000 | 0 | 9,000 | |
| Additional paid-in capital | 531 | 503 | 342 | 293 | 285 | |
| Accumulated other comprehensive income | 68,000 | 0 | — | — | — | |
| Accumulated deficit | −449 | −370 | −335 | −304 | −262 | |
| Total stockholders equity | 83 | 133 | 7 | −11 | 23 | |
| Total liabilities, mezzanine equity and stockholders equity | 116 | 151 | 21 | 33 | 80 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation and amortization | 344,000 | 169,000 | 158,000 | 166,000 | 2 | |
| Stock-based compensation | 14 | 6 | 3 | 8 | 8 | |
| Accretion of available-for-sale investments, net | −690,000 | 0 | — | — | — | |
| Transaction costs paid pursuant to private placement | 0 | 7 | 0 | — | — | |
| Transaction costs paid upon exercise of warrants issued in private placement | 0 | 2 | 0 | — | — | |
| Contingent consideration paid pursuant to AlmataBio Transaction | 0 | −13 | 0 | — | — | |
| Lease early termination fee | 0 | −309,000 | 0 | — | — | |
| Deferred taxes | 165,000 | 114,000 | 14,000 | 28,000 | — | |
| Other receivables | 0 | −475,000 | 2 | 2 | −2 | |
| Prepaid expenses and other assets | −3 | −3 | 447,000 | 1 | 287,000 | |
| Accounts payable | −146,000 | −163,000 | −2 | −487,000 | 796,000 | |
| Accrued expenses and other liabilities, excluding lease liability | 7 | −1 | −9 | −4 | 3 | |
| Lease liability, net | −87,000 | −88,000 | −76,000 | −9,000 | −45,000 | |
| Net cash used in operating activities | −52 | −49 | −31 | −27 | −71 | |
| Purchase of investments | −114 | 0 | — | — | — | |
| Maturities of investments | 32 | 0 | — | — | — | |
| Cash assumed from AlmataBio Transaction | 0 | 356,000 | 0 | — | — | |
| Net cash (used in) provided by investing activities | −82 | 356,000 | −133,000 | −95,000 | −113,000 | |
| Proceeds from sale of common stock pursuant to ATM Program | 15 | 0 | 32 | 0 | 29 | |
| Transaction costs paid pursuant to ATM Program | −462,000 | 0 | — | — | — | |
| Proceeds from exercise of stock options | 774,000 | 0 | — | — | — | |
| Proceeds from issuance of common stock under employee stock purchase plan, net of cash paid related to withholding shares to satisfy tax withholding obligations | 23,000 | 68,000 | 67,000 | 73,000 | 366,000 | |
| Cash paid related to withholding shares to satisfy RSU tax withholding obligations | −510,000 | 0 | — | — | 0 | |
| Proceeds from private placement investment, gross | 0 | 116 | 0 | — | 0 | |
| Transaction costs paid pursuant to private placement | 0 | −7 | — | — | — | |
| Proceeds from exercise of warrants issued in private placement, gross | 0 | 69 | 0 | — | — | |
| Transaction costs paid upon exercise of warrants issued in private placement | 0 | −2 | — | — | — | |
| Net cash provided by financing activities | 15 | 176 | 25 | −15 | 107 | |
| (Decrease) increase in cash, cash equivalents, and restricted cash | −119 | 127 | −6 | −42 | 36 | |
| Issuance of common stock and Series C Preferred Stock pursuant to AlmataBio Transaction | 0 | 12 | 0 | — | — | |
| Remeasurement of lease | 0 | −312,000 | 0 | — | — |