Bolt Biotherapeutics, Inc.
Business
Bolt Biotherapeutics, Inc. is a clinical-stage biopharmaceutical company developing novel immunotherapies that activate myeloid biology to treat cancer. Its main products are Boltbody™ ISACs—antibody-based therapeutics that combine tumor-targeting antibodies with immune-stimulating linker-payloads—and a dectin-2 agonist antibody (BDC-3042). The company operates R&D-focused business segments including proprietary Boltbody ISAC programs, a myeloid-directed agonist antibody program, and partnered collaboration programs with companies such as Genmab, Toray, and Innovent. Bolt pursues global clinical development and commercialization through collaborations and relies on third-party CDMOs for manufacturing and distribution.
Summary from filing dated 2025-03-24
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Collaboration revenue | 8 | 8 | 8 | 6 | 1 | |
| Research and development | 29 | 57 | 62 | 73 | 76 | |
| General and administrative | 14 | 18 | 23 | 23 | 18 | |
| Restructuring charges | 1 | 3 | 0 | — | — | |
| Impairment charges | 0 | 1 | 0 | — | — | |
| Total operating expense | 44 | 81 | 84 | 96 | 94 | |
| Loss from operations | −36 | −73 | −76 | −90 | −93 | |
| Interest income, net | 2 | 5 | 7 | 2 | 281,000 | |
| Other income, net | 241,000 | 5 | 0 | — | — | |
| Total other income, net | 3 | 10 | 7 | 2 | −6 | |
| Net loss | −33 | −63 | −69 | −88 | −99 | |
| Net unrealized (loss) gain on marketable securities | −118,000 | 60,000 | 956,000 | −600,000 | −300,000 | |
| Comprehensive loss | −33 | −63 | −68 | −89 | −99 | |
| Net loss per share, basic | −17.85 | −33.06 | −1.83 | −2.36 | −2.97 | |
| Net loss per share, diluted | −17.85 | −33.06 | −1.83 | −2.36 | −2.97 | |
| Weighted-average shares outstanding, basic | 2 | 2 | 38 | 37 | 33 | |
| Weighted-average shares outstanding, diluted | 2 | 2 | 38 | 37 | 33 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 12 | 7 | 11 | 9 | 27 | |
| Short-term investments | 16 | 40 | 91 | 160 | 159 | |
| Restricted cash | 200,000 | 784,000 | 0 | — | — | |
| Prepaid expenses and other current assets | 3 | 3 | 4 | 4 | 3 | |
| Total current assets | 30 | 51 | 106 | 173 | 189 | |
| Property and equipment, net | 1 | 3 | 5 | 6 | 6 | |
| Operating lease right-of-use assets | 19 | 22 | 19 | 22 | 24 | |
| Restricted cash, non-current | 2 | 981,000 | 2 | 2 | 2 | |
| Long-term investments | 4 | 23 | 26 | 24 | 85 | |
| Other assets | 138,000 | 62,000 | 2 | 1 | 1 | |
| Total assets | 57 | 100 | 160 | 228 | 308 | |
| Accounts payable | 1 | 2 | 3 | 4 | 4 | |
| Accrued expenses and other current liabilities | 4 | 9 | 12 | 15 | 12 | |
| Deferred revenue | 449,000 | 3 | 2 | 2 | 3 | |
| Operating lease liabilities | 3 | 2 | 3 | 2 | 3 | |
| Total current liabilities | 8 | 16 | 20 | 23 | 21 | |
| Operating lease liabilities, net of current portion | 20 | 23 | 17 | 20 | 22 | |
| Deferred revenue, non-current | 2 | 4 | 9 | 13 | 14 | |
| Other long-term liabilities | 132,000 | 0 | 43,000 | 42,000 | 210,000 | |
| Total liabilities | 30 | 42 | 47 | 56 | 58 | |
| Commitments and contingencies (Note 6) | — | — | — | — | — | |
| Common stock, $0.00001 par value; 200,000,000 shares authorized at December 31, 2025 and 2024; 1,920,566 and 1,916,943 shares issued and outstanding at December 31, 2025 and 2024, respectively | 0 | 0 | 0 | 0 | 0 | |
| Additional paid-in capital | 487 | 485 | 477 | 468 | 457 | |
| Accumulated other comprehensive gain | −21,000 | 97,000 | 37,000 | −919,000 | −321,000 | |
| Accumulated deficit | −461 | −427 | −364 | −295 | −207 | |
| Total stockholders' equity | 27 | 57 | 113 | 172 | 250 | |
| Total liabilities and stockholders' equity | 57 | 100 | 160 | 228 | 308 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −33 | −63 | −69 | −88 | −99 | |
| Depreciation and amortization | 1 | 2 | 2 | 2 | 1 | |
| Stock-based compensation expense | 3 | 7 | 9 | 10 | 9 | |
| Accretion of discount on marketable securities | −670,000 | −3 | −4 | 184,000 | 3 | |
| Gain on sale of fixed assets | −288,000 | −70,000 | 0 | — | — | |
| Non-cash lease expense | 3 | 2 | 3 | 3 | 2 | |
| Prepaid expenses and other assets | 76,000 | 3 | −454,000 | −903,000 | −568,000 | |
| Accounts payable and accrued expenses | −5 | −5 | −3 | 3 | 7 | |
| Operating lease liabilities, net | −2 | −1 | −2 | −3 | −1 | |
| Deferred revenue | −5 | −5 | −4 | −2 | 16 | |
| Other long-term liabilities | 132,000 | −43,000 | 1,000 | −164,000 | 4,000 | |
| Net cash used in operating activities | −40 | −61 | −70 | −77 | −57 | |
| Purchase of property and equipment | −72,000 | −41,000 | −206,000 | −2 | −2 | |
| Proceeds from sales of property and equipment | 963,000 | 148,000 | 0 | — | — | |
| Purchases of marketable securities | −29 | −89 | −165 | −181 | −313 | |
| Maturities of marketable securities | 72 | 146 | 236 | 241 | 84 | |
| Net cash provided by investing activities | 44 | 58 | 71 | 58 | −232 | |
| Proceeds from issuance of common stock | 19,000 | 108,000 | 253,000 | 503,000 | 1 | |
| Net cash provided by financing activities | 19,000 | 108,000 | 253,000 | 503,000 | 311 | |
| NET INCREASE (DECREASE) IN CASH | 4 | −4 | 2 | −18 | 22 | |
| Right of use assets obtained in exchange for operating lease obligations | 0 | 6 | 0 | 852,000 | 15 |