Barinthus Biotherapeutics plc.
Business
Barinthus Biotherapeutics plc is a clinical-stage biopharmaceutical company developing immunotherapeutic drug candidates for autoimmune and inflammatory diseases, as well as infectious diseases and oncology. It offers product candidates built on a SNAP-TI immune tolerance platform (lead candidate VTP-1000 for celiac disease) and viral vector platforms ChAdOx and MVA with programs such as VTP-300 (HBV), VTP-850 (prostate cancer), VTP-200 (HPV) and prophylactic vaccines. Its operations are organized around two core platforms—immune tolerance (SNAP-TI) and CD8+ T cell induction (viral vectors)—alongside licensing, partnerships and clinical development. Barinthus conducts global clinical trials and advances programs through collaborations and partner-mediated manufacturing and commercialization channels across the U.K., U.S., Europe, Australia and other international markets.
Summary from filing dated 2025-03-20
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenue | 0 | 15 | 802,000 | 45 | 268,000 | |
| Research and development | 26 | 42 | 45 | 42 | 20 | |
| General and administrative | 41 | 30 | 40 | 6 | 25 | |
| Impairment of intangible assets | 5 | 0 | — | — | — | |
| Goodwill impairment | 0 | 12 | 0 | — | — | |
| Total operating expenses | 71 | 84 | 85 | 49 | 45 | |
| Other operating income | 506,000 | 1 | 0 | — | — | |
| Loss from operations | −71 | −68 | −84 | −4 | −45 | |
| Interest income | 2 | 3 | 3 | 3 | 2,000 | |
| Interest expense | −51,000 | −53,000 | −28,000 | — | — | |
| Research and development incentives | 2 | 4 | 4 | 1 | 4 | |
| Other income | 16,000 | 135,000 | 1 | 567,000 | 332,000 | |
| Total other income, net | 4 | 7 | 7 | 5 | −6 | |
| Loss before income tax | −67 | −61 | −77 | 850,000 | −51 | |
| Tax benefit | 175,000 | 44,000 | 3 | 4 | 28,000 | |
| Net loss | −66 | −61 | −73 | 5 | −51 | |
| Net loss attributable to noncontrolling interest | 30,000 | 109,000 | 100,000 | 21,000 | 247,000 | |
| Net loss attributable to Barinthus Biotherapeutics plc shareholders | −66 | −61 | −73 | 5 | −51 | |
| Weighted-average ordinary shares outstanding, basic (in shares) | 41 | 39 | 38 | 37 | 26 | |
| Weighted-average ordinary shares outstanding, diluted (in shares) | 41 | 39 | 38 | 38 | 26 | |
| Net loss per share attributable to ordinary shareholders, basic (in usd per share) | −1.64 | −1.55 | −1.91 | 0.14 | −1.96 | |
| Net loss per share attributable to ordinary shareholders, diluted (in usd per share) | −1.64 | −1.55 | −1.91 | 0.14 | −1.96 | |
| Other comprehensive gain/(loss) foreign currency translation adjustments | 10 | −3 | 10 | −25 | −7 | |
| Comprehensive loss | −56 | −64 | −63 | −20 | −58 | |
| Comprehensive loss/(gain) attributable to noncontrolling interest | 22,000 | 105,000 | 94,000 | 132,000 | 250,000 | |
| Comprehensive loss attributable to Barinthus Biotherapeutics plc shareholders | −56 | −64 | −63 | −20 | −58 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 70 | 111 | 142 | 194 | 214 | |
| Restricted cash | 1 | 2 | 0 | — | — | |
| Research and development incentives receivable | 1 | 7 | 5 | 5 | 6 | |
| Prepaid expenses and other current assets | 5 | 6 | 10 | 8 | 6 | |
| Total current assets | 78 | 126 | 157 | 213 | 227 | |
| Property and equipment, net | 4 | 7 | 12 | 8 | 2 | |
| Intangible assets, net | 14 | 22 | 25 | 28 | 31 | |
| Right of use assets, net | 2 | 4 | 8 | 8 | 7 | |
| Other assets | 930,000 | 881,000 | 882,000 | 976,000 | 804,000 | |
| Total assets | 98 | 160 | 215 | 270 | 281 | |
| Accounts payable | 350,000 | 2 | 2 | 4 | 2 | |
| Accrued expenses and other current liabilities | 6 | 10 | 9 | 8 | 8 | |
| Deferred income | 1 | 2 | 0 | — | — | |
| Operating lease liability - current | 2 | 2 | 2 | 433,000 | 523,000 | |
| Total current liabilities | 10 | 16 | 13 | 12 | 11 | |
| Operating lease liability - non-current | 9 | 10 | 11 | 8 | 7 | |
| Contingent consideration | 3 | 3 | 2 | 2 | 2 | |
| Other non-current liabilities | 1 | 1 | 1 | 965,000 | — | |
| Deferred tax liability, net | 254,000 | 438,000 | 574,000 | — | — | |
| Total liabilities | 24 | 30 | 28 | 27 | 28 | |
| Commitments and contingencies (Note 16) | — | — | — | — | — | |
| Ordinary shares, 0.000025 nominal value; 40,848,893 shares authorized, issued and outstanding (December 31, 2024: authorized, issued and outstanding: 40,234,663) | 1,000 | 1,000 | 1,000 | 1,000 | 1,000 | |
| Deferred A shares, 1 nominal value; 63,443 shares authorized, issued and outstanding (December 31, 2024: authorized, issued and outstanding: 63,443) | 86,000 | 86,000 | — | — | — | |
| Additional paid-in capital | 394 | 393 | 387 | 380 | 369 | |
| Accumulated deficit | −304 | −238 | −177 | −103 | −109 | |
| Accumulated other comprehensive loss foreign currency translation adjustments | −16 | −26 | −23 | −33 | −8 | |
| Total stockholders equity attributable to Barinthus Biotherapeutics plc shareholders | 74 | 130 | 187 | 243 | 252 | |
| Noncontrolling interest | 84,000 | 106,000 | 211,000 | 305,000 | 437,000 | |
| Total stockholders equity | 74 | 130 | 187 | 243 | 253 | |
| Total liabilities and stockholders equity | 98 | 160 | 215 | 270 | 281 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Share based compensation | 468,000 | 5 | 5 | 10 | 16 | |
| Impairment of long-lived assets | 6 | 5 | — | — | — | |
| Depreciation and amortization | 6 | 6 | 5 | 4 | 602,000 | |
| Non-cash lease expenses | 3 | 1 | 1 | 1 | 338,000 | |
| Unrealized foreign exchange loss | 4 | −649,000 | 8 | −25 | — | |
| Change in contingent consideration | 26,000 | 866,000 | 55,000 | −73,000 | — | |
| Non-cash interest expense | 51,000 | 48,000 | 28,000 | 19,000 | 813,000 | |
| Deferred tax benefit | −175,000 | −44,000 | −3 | −4 | −119,000 | |
| Profit on sale of property and equipment | −200,000 | 0 | 0 | −348,000 | — | |
| Prepaid expenses and other current assets | 2 | 4 | 2 | −2 | −4 | |
| Research and development incentives receivable | 6 | −2 | −127,000 | 1 | −4 | |
| Accounts payable | −2 | 898,000 | −3 | 1 | −4 | |
| Accrued expenses and other current liabilities | −4 | 456,000 | 2 | 751,000 | 4 | |
| Deferred income | −506,000 | 2 | 0 | — | — | |
| Operating lease liabilities | −2 | −2 | −445,000 | 0 | — | |
| Net cash used in operating activities | −48 | −29 | −51 | −14 | −33 | |
| Proceeds from sale of property and equipment | 500,000 | 0 | 0 | 388,000 | — | |
| Purchases of property and equipment | −37,000 | −892,000 | −5 | −6 | −1 | |
| Net cash provided by/(used) in investing activities | 416,000 | −892,000 | −5 | −6 | −13 | |
| Issue of shares from the exercise of stock options | 2,000 | 0 | 0 | 0 | 9,000 | |
| Proceeds from issue of ordinary shares, net of issuance costs | 0 | 2 | 2 | 484,000 | 103 | |
| Net cash provided by financing activities | 2,000 | 2 | 2 | 325,000 | 223 | |
| Effect of exchange rates on cash, cash equivalents and restricted cash | 7 | −2 | 2 | 187,000 | −6 | |
| Net decrease in cash, cash equivalents and restricted cash | −41 | −30 | −52 | −20 | 171 |