ENANTA PHARMACEUTICALS INC
Business
ENANTA PHARMACEUTICALS INC discovers and develops small‑molecule drugs focused on virology and immunology indications using chemistry‑driven drug discovery capabilities. Its principal products and programs include out‑licensed HCV protease inhibitors (glecaprevir, marketed in combination as MAVYRET/MAVIRET by AbbVie) and wholly‑owned clinical‑stage antivirals for RSV (zelicapavir, EDP‑323), SARS‑CoV‑2 (EDP‑235), HBV (EDP‑514) and preclinical immunology candidates targeting KIT and STAT6. The company operates through wholly‑owned development programs and out‑licensing/collaboration arrangements (notably with AbbVie) and relies on CROs, contract manufacturers and partners. Its programs target global markets with commercialization and distribution primarily executed via pharmaceutical collaborators, licensing deals and third‑party channels.
Summary from filing dated 2025-11-19
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-09-30 | FY 2024 2024-09-30 | FY 2023 2023-09-30 | FY 2022 2022-09-30 | FY 2021 2021-09-30 |
|---|---|---|---|---|---|---|
| Total revenue | 65 | 68 | 79 | 86 | 97 | |
| Research and development | 107 | 131 | 164 | 165 | 174 | |
| General and administrative | 44 | 58 | 53 | 45 | 33 | |
| Total operating expenses | 151 | 189 | 216 | 210 | 207 | |
| Loss from operations | −85 | −122 | −137 | −124 | −110 | |
| Interest expense | −8 | −11 | −5 | 0 | — | |
| Interest and investment income, net | 9 | 15 | 11 | 2 | — | |
| Change in fair value of Series 1 nonconvertible preferred stock | 39,000 | 73,000 | 0 | 83,000 | −27,000 | |
| Total other income, net | 2 | 4 | 6 | 2 | 2 | |
| Loss before income taxes | −84 | −118 | −131 | −122 | −108 | |
| Income tax benefit (expense) | 2 | 2 | −3 | 433,000 | 29 | |
| Net loss | −82 | −116 | −134 | −122 | −79 | |
| Basic (per share) | −3.84 | −5.48 | −6.38 | −5.91 | −3.92 | |
| Diluted (per share) | −3.84 | −5.48 | −6.38 | −5.91 | −3.92 | |
| Basic (shares) | 21,336 | 21,157 | 20,969 | 20,603 | 20,171 | |
| Diluted (shares) | 21,336 | 21,157 | 20,969 | 20,603 | 20,171 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-09-30 | FY 2024 2024-09-30 | FY 2023 2023-09-30 | FY 2022 2022-09-30 | FY 2021 2021-09-30 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 32 | 37 | 85 | 44 | 57 | |
| Short-term marketable securities | 157 | 211 | 285 | 205 | 187 | |
| Accounts receivable | 7 | 7 | 9 | 20 | 24 | |
| Prepaid expenses and other current assets | 9 | 12 | 13 | 13 | 14 | |
| Income tax receivable | 0 | 32 | 31 | 29 | 37 | |
| Short-term restricted cash | 0 | 608,000 | 0 | — | — | |
| Total current assets | 204 | 300 | 423 | 312 | 319 | |
| Property and equipment, net | 35 | 33 | 12 | 6 | 6 | |
| Operating lease, right-of-use assets | 38 | 41 | 23 | 24 | 5 | |
| Long-term restricted cash | 3 | 3 | 4 | — | — | |
| Other long-term assets | 92,000 | 94,000 | 803,000 | 696,000 | 92,000 | |
| Total assets | 281 | 377 | 462 | 375 | 439 | |
| Accounts payable | 2 | 8 | 4 | 6 | 10 | |
| Accrued expenses and other current liabilities | 13 | 14 | 18 | 21 | 22 | |
| Liability related to the sale of future royalties | 31 | 34 | 35 | 0 | — | |
| Operating lease liabilities | 3 | 2 | 5 | 3 | 4 | |
| Total current liabilities | 49 | 58 | 63 | 30 | 36 | |
| Liability related to the sale of future royalties, net of current portion | 111 | 135 | 159 | 0 | — | |
| Operating lease liabilities, net of current portion | 55 | 54 | 21 | 22 | 1 | |
| Series 1 nonconvertible preferred stock | 1 | 1 | 1 | 1 | 2 | |
| Other long-term liabilities | 260,000 | 231,000 | 663,000 | 454,000 | 558,000 | |
| Total liabilities | 216 | 248 | 246 | 54 | 39 | |
| Commitments and contingencies (Note 13) | — | — | — | — | — | |
| Common stock; $0.01 par value per share, 100,000 shares authorized; 21,387 and 21,194 shares issued and outstanding at September 30, 2025 and September 30, 2024, respectively | 214,000 | 212,000 | 211,000 | 208,000 | 202,000 | |
| Additional paid-in capital | 470 | 451 | 425 | 398 | 351 | |
| Accumulated other comprehensive (loss) gain | −339,000 | 302,000 | −1 | −4 | −382,000 | |
| Accumulated deficit | −405 | −323 | −207 | −73 | 49 | |
| Total stockholders' equity | 65 | 129 | 217 | 321 | 399 | |
| Total liabilities and stockholders' equity | 281 | 377 | 462 | 375 | 439 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-09-30 | FY 2024 2024-09-30 | FY 2023 2023-09-30 | FY 2022 2022-09-30 | FY 2021 2021-09-30 |
|---|---|---|---|---|---|---|
| Net loss | −82 | −116 | −134 | −122 | −79 | |
| Stock-based compensation expense | 19 | 27 | 28 | 27 | 21 | |
| Depreciation and amortization expense | 5 | 2 | 2 | 3 | 3 | |
| Non-cash interest associated with the sale of future royalties | −630,000 | −135,000 | 5 | 0 | 0 | |
| Non-cash royalty revenue | −283,000 | 2 | −10 | 0 | 0 | |
| Premium paid on marketable securities | 0 | 0 | −73,000 | −846,000 | −4 | |
| Amortization (accretion) of premiums (discounts) on marketable securities | 503,000 | −1 | −3 | 1 | 2 | |
| Loss on disposal of property and equipment | 6,000 | 16,000 | 150,000 | 0 | 0 | |
| Accounts receivable | −236,000 | 2 | 12 | 3 | −84,000 | |
| Prepaid expenses and other current assets | 4 | 850,000 | 182,000 | 743,000 | −533,000 | |
| Income tax receivable | 32 | −995,000 | −2 | 9 | −24 | |
| Operating lease, right-of-use assets | 4 | 6 | 5 | 5 | 5 | |
| Other long-term assets | 2,000 | 709,000 | −107,000 | −604,000 | 0 | |
| Accounts payable | −1 | −414,000 | −1 | −5 | 4 | |
| Accrued expenses | 58,000 | −6 | −3 | −1 | 8 | |
| Operating lease liabilities | 1 | 5 | −3 | −4 | −6 | |
| Other long-term liabilities | 29,000 | −432,000 | 209,000 | −104,000 | −520,000 | |
| Net cash used in operating activities | −19 | −79 | −103 | −85 | −70 | |
| Purchase of marketable securities | −210 | −307 | −373 | −171 | −307 | |
| Proceeds from maturities and sale of marketable securities | 263 | 383 | 329 | 228 | 345 | |
| Purchase of property and equipment | −13 | −18 | −9 | −2 | −750,000 | |
| Net cash provided by (used in) investing activities | 40 | 58 | −54 | 55 | 37 | |
| Payments on royalty sale liability, net of imputed interest | −26 | −27 | 0 | 0 | — | |
| Proceeds from the exercise of stock options | 145,000 | 147,000 | 2 | 21 | 4 | |
| Proceeds from the sale of future royalties | 0 | 0 | 200 | 0 | 0 | |
| Payments for debt issuance costs | 0 | 0 | −325,000 | 0 | 0 | |
| Payments for settlement of share-based awards | −277,000 | −294,000 | −4 | −1 | −534,000 | |
| Net cash (used in) provided by financing activities | −27 | −28 | 198 | 20 | 3 | |
| Net (decrease) increase in cash, cash equivalents and restricted cash | −6 | −48 | 41 | −10 | −30 | |
| Cash paid for taxes | 109,000 | 241,000 | 5 | 0 | 32,000 | |
| Cash paid for interest | 9 | 12 | 2 | 0 | — | |
| Cash received from tenant improvement allowances | 6 | 9 | 2 | 0 | — | |
| Cash received from income tax refund | 34 | 0 | 0 | — | — | |
| Purchases of fixed assets included in accounts payable and accrued expenses | 0 | 6 | 424,000 | 1 | 137,000 | |
| Operating lease liabilities arising from obtaining right-of-use assets | 1 | 24 | 4 | 24 | 3 |