Foghorn Therapeutics Inc.
Business
Foghorn Therapeutics Inc. is a clinical-stage precision therapeutics biotechnology company that develops medicines by correcting abnormal gene expression through selective targeting of the chromatin regulatory system. It advances small-molecule modalities including enzymatic inhibitors, targeted protein degraders and transcription factor disruptors as its primary product candidates and research outputs. Its operations center on a proprietary Gene Traffic Control® platform supporting target identification, scalable production of chromatin components, assay development, and discovery-to-clinic translation, and it conducts partnered clinical development programs. It distributes and develops its candidates primarily through clinical trials and strategic collaborations with biopharmaceutical partners globally.
Summary from filing dated 2025-03-06
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Collaboration revenue | 31 | 23 | 34 | 19 | 1 | |
| Research and development | 85 | 95 | 110 | 106 | 80 | |
| General and administrative | 28 | 28 | 32 | 31 | 22 | |
| Gain on lease modification | −2 | 0 | — | — | — | |
| Impairment of long-lived assets | 6 | 2 | 0 | — | — | |
| Total operating expenses | 117 | 125 | 142 | 136 | 102 | |
| Loss from operations | −86 | −103 | −108 | −117 | −101 | |
| Interest income | 9 | 12 | 11 | 6 | 59,000 | |
| Other income, net | 3 | 4 | 3 | 3 | 3 | |
| Total other income, net | 12 | 16 | 14 | 8 | −586,000 | |
| Net loss | −74 | −87 | −98 | −109 | −101 | |
| Net loss per share attributable to common stockholdersbasic (in dollars per share) | −1.18 | −1.58 | −2.34 | −2.62 | −2.73 | |
| Net loss per share attributable to common stockholdersdiluted (in dollars per share) | −1.18 | −1.58 | −2.34 | −2.62 | −2.73 | |
| Weighted average common shares outstandingbasic (in shares) | 63 | 55 | 42 | 42 | 37 | |
| Weighted average common shares outstandingdiluted (in shares) | 63 | 55 | 42 | 42 | 37 | |
| Unrealized gains (losses) on marketable securities | −111,000 | 961,000 | 3 | −4 | −3,000 | |
| Total other comprehensive gain (loss) | −111,000 | 961,000 | 3 | −4 | −3,000 | |
| Total comprehensive loss | −74 | −86 | −95 | −113 | −101 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 81 | 55 | 80 | 52 | 101 | |
| Marketable securities | 78 | 188 | 154 | 294 | 53 | |
| Restricted cash | 1 | 0 | — | — | — | |
| Prepaid expenses and other current assets | 3 | 6 | 6 | 6 | 5 | |
| Total current assets | 163 | 250 | 240 | 351 | 460 | |
| Property and equipment, net | 2 | 10 | 13 | 15 | 18 | |
| Restricted cash | 2 | 2 | 2 | 2 | 2 | |
| Other assets | 4,000 | 68,000 | 1 | 2 | 2 | |
| Operating lease right-of-use assets | 31 | 23 | 30 | 34 | 39 | |
| Total assets | 198 | 284 | 286 | 405 | 520 | |
| Accounts payable | 4 | 4 | 6 | 5 | 4 | |
| Accrued expenses and other current liabilities | 11 | 9 | 9 | 11 | 10 | |
| Operating lease liabilities | 923,000 | 9 | 9 | 6 | 7 | |
| Deferred revenue | 43 | 46 | 35 | 33 | 28 | |
| Total current liabilities | 60 | 67 | 58 | 55 | 49 | |
| Operating lease liabilities, net of current portion | 40 | 28 | 37 | 46 | 51 | |
| Deferred revenue, net of current portion | 206 | 234 | 268 | 304 | 323 | |
| Other liabilities | 556,000 | 0 | 0 | 29,000 | 143,000 | |
| Total liabilities | 307 | 330 | 363 | 405 | 423 | |
| Commitments and contingencies (Note 11) | — | — | — | — | — | |
| Preferred stock, $0.0001 par value; 25,000,000 shares authorized as of December 31, 2025 and 2024; no shares issued and outstanding as of December 31, 2025 and 2024 | 0 | 0 | 0 | 0 | 0 | |
| Common stock, $0.0001 par value; 175,000,000 shares authorized at December 31, 2025 and 2024; 56,657,329 shares issued and outstanding at December 31, 2025 and 55,594,131 shares issued and outstanding at December 31, 2024 | 6,000 | 6,000 | 4,000 | 4,000 | 4,000 | |
| Additional paid-in capital | 524 | 513 | 395 | 377 | 361 | |
| Accumulated other comprehensive gain | 24,000 | 135,000 | −826,000 | −4 | −10,000 | |
| Accumulated deficit | −633 | −558 | −472 | −373 | −264 | |
| Total stockholders deficit | −109 | −46 | −77 | 112,000 | 97 | |
| Total liabilities and stockholders deficit | 198 | 284 | 286 | 405 | 520 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Stock-based compensation expense | 10 | 12 | 16 | 14 | — | |
| Depreciation and amortization expense | 3 | 3 | 4 | 3 | 3 | |
| Loss on disposal of property and equipment | 31,000 | 0 | 3,000 | 6,000 | 0 | |
| Noncash lease expense | 4 | 6 | — | — | — | |
| Accretion of discount on marketable securities | −2 | −5 | −3 | −1 | 179,000 | |
| Prepaid expenses and other current assets | 3 | 1 | 741,000 | −307,000 | −2 | |
| Accounts payable | 481,000 | −2 | 846,000 | 2 | 135,000 | |
| Accrued expenses and other liabilities | 2 | −564,000 | −2 | 1 | 3 | |
| Operating lease liabilities | −7 | −8 | −8 | — | — | |
| Deferred revenue | −31 | −23 | −34 | −14 | 336 | |
| Net cash used in operating activities | −86 | −100 | −118 | 194 | −50 | |
| Purchases of property and equipment | −50,000 | −906,000 | −1 | −1 | −3 | |
| Purchases of marketable securities | −131 | −261 | −74 | −409 | −100 | |
| Proceeds from maturities of marketable securities | 243 | 232 | 220 | 166 | 139 | |
| Net cash provided by (used in) investing activities | 112 | −30 | 144 | −244 | 36 | |
| Payments of public offering costs | 0 | −585,000 | 0 | — | — | |
| Proceeds from issuance of common stock upon exercise of stock options and employee stock purchase plan | 483,000 | 3 | 2 | 2 | 1 | |
| Net cash provided by financing activities | 1 | 105 | 2 | 2 | 22 | |
| Net increase (decrease) in cash, cash equivalents and restricted cash | 27 | −25 | 28 | −49 | 8 | |
| Cash paid for taxes | 9,000 | 860,000 | 4 | — | — | |
| Purchases of property and equipment included in accounts payable and accrued expenses | 0 | 22,000 | 35,000 | 160,000 | 295,000 | |
| Asset acquired in finance lease | 1 | 0 | — | — | — |