Humacyte, Inc.
Business
Humacyte, Inc. is a commercial-stage biotechnology platform company that develops universally implantable, bioengineered human tissues and tissue constructs at commercial scale. Its principal products and product candidates are acellular tissue engineered vessels (ATEVs), marketed as Symvess for extremity arterial trauma, plus a pipeline of ATEV variants targeting vascular trauma, arteriovenous access for hemodialysis, peripheral artery disease, coronary bypass, pediatric cardiac indications, and the BioVascular Pancreas cell‑delivery concept. The company operates R&D, clinical development, and modular commercial manufacturing (LUNA200) functions and pursues strategic collaborations and licensing. It commercializes in the United States via direct hospital and trauma center channels and leverages a distribution partnership with Fresenius for markets outside the U.S.
Summary from filing dated 2025-03-31
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Revenue | 2 | 0 | — | — | — | |
| Cost of goods sold | 10 | 0 | — | — | — | |
| Research and development | 69 | 89 | 77 | 63 | 61 | |
| General and administrative | 31 | 26 | 23 | 23 | 21 | |
| Total operating expenses | 110 | 114 | — | — | — | |
| Loss from operations | −108 | −114 | −100 | −85 | −81 | |
| Interest income | 3 | 4 | 5 | 3 | 16,000 | |
| Change in fair value of Contingent Earnout Liability | 59 | −33 | −10 | 76 | 56 | |
| Interest expense | −11 | −9 | −7 | — | — | |
| Change in fair value of derivatives | 39 | 4 | −260,000 | 417,000 | — | |
| Loss on extinguishment of debt | −22 | 0 | −2 | 0 | 3 | |
| Total other expense, net | 67 | −34 | −11 | 73 | 55 | |
| Net loss and comprehensive loss | −41 | −149 | −111 | −12 | −26 | |
| Net loss per share attributable to common stockholders, basic (in dollars per share) | −0.26 | −1.26 | −1.07 | −0.12 | −0.66 | |
| Net loss per share attributable to common stockholders, diluted (in dollars per share) | −0.26 | −1.26 | −1.07 | −0.12 | −0.66 | |
| Weighted-average shares outstanding used in computing net loss per share attributable to common stockholders, basic (in shares) | 158 | 118 | 103 | 103 | 40 | |
| Weighted-average shares outstanding used in computing net loss per share attributable to common stockholders, diluted (in shares) | 158 | 118 | 103 | 103 | 40 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 51 | 45 | 80 | 150 | 218 | |
| Inventory, net | 14 | 0 | — | — | — | |
| Accounts receivable | 441,000 | 0 | 0 | 31,000 | 176,000 | |
| Prepaid expenses and other current assets | 3 | 3 | 3 | 2 | 4 | |
| Total current assets | 68 | 48 | 83 | 154 | 229 | |
| Restricted cash | 209,000 | 50 | 209,000 | — | — | |
| Property and equipment, net | 19 | 23 | 27 | 30 | 35 | |
| Finance lease right-of-use assets, net | 29 | 16 | 17 | 19 | 21 | |
| Other long-term assets | 672,000 | 1 | 632,000 | 682,000 | — | |
| Total assets | 116 | 138 | 128 | 204 | 287 | |
| Accounts payable | 5 | 4 | 6 | 2 | 2 | |
| Accrued expenses | 11 | 11 | 9 | 7 | 7 | |
| Finance lease obligation, current portion | 2 | 3 | 3 | 2 | 2 | |
| Revenue interest liability, current portion | 0 | 885,000 | — | — | — | |
| Other current liabilities | 0 | 238,000 | 53,000 | — | — | |
| Total current liabilities | 18 | 20 | 18 | 20 | 11 | |
| Long-term debt | 35 | 0 | — | — | — | |
| Contingent Earnout Liability | 11 | 71 | 38 | 28 | 104 | |
| Revenue interest liability | 0 | 63 | — | — | — | |
| Common stock warrant liabilities | 19 | 19 | 78,000 | 80,000 | 497,000 | |
| Finance lease obligation, net of current portion | 27 | 14 | 16 | 19 | 21 | |
| Contingent derivative liability | 0 | 2 | 3 | 0 | — | |
| Other long-term liabilities | 2 | 983,000 | 711,000 | 712,000 | — | |
| Total liabilities | 113 | 191 | 115 | 87 | 164 | |
| Preferred stock, $0.0001 par value; 20,000,000 shares designated as of December 31, 2025 and 2024, 0 shares issued and outstanding as of December 31, 2025 and 2024 | 0 | 0 | 0 | 0 | 0 | |
| Common stock, $0.0001 par value; 350,000,000 and 250,000,000 shares authorized as of December 31, 2025 and 2024, respectively; 193,000,611 and 130,027,509 shares issued and outstanding as of December 31, 2025 and 2024, respectively | 20,000 | 13,000 | 10,000 | 10,000 | 10,000 | |
| Additional paid-in capital | 730 | 633 | 551 | 543 | 537 | |
| Accumulated deficit | −727 | −686 | −537 | −427 | −415 | |
| Total stockholders equity (deficit) | 3 | −53 | 14 | 117 | 122 | |
| Total liabilities and stockholders equity (deficit) | 116 | 138 | 128 | 204 | 287 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation expense | 5 | 5 | 6 | 6 | 6 | |
| Stock-based compensation expense | 10 | 6 | 7 | 6 | 10 | |
| Non-cash interest expense | 9 | 8 | 3 | 0 | — | |
| Loss on disposal of property and equipment | 5,000 | 4,000 | 18,000 | 6,000 | 0 | |
| Inventory reserve | 9 | 0 | — | — | — | |
| Amortization expense | 2 | 2 | 2 | 2 | 2 | |
| Non-cash operating lease costs | 44,000 | 53,000 | 50,000 | 45,000 | 42,000 | |
| Accounts receivable | −261,000 | 0 | 31,000 | 145,000 | −63,000 | |
| Inventory | −22 | 0 | — | — | — | |
| Prepaid expenses and other current assets | −527,000 | 88,000 | −388,000 | 1 | −2 | |
| Accounts payable | 973,000 | −2 | 5 | −509,000 | −197,000 | |
| Accrued expenses | −2 | 2 | 2 | 247,000 | 2 | |
| Operating lease obligation | −44,000 | −53,000 | −50,000 | −45,000 | −42,000 | |
| Net cash used in operating activities | −105 | −98 | −73 | −71 | −81 | |
| Purchase of property and equipment, net | −884,000 | −2 | −2 | −1 | −220,000 | |
| Net cash used in investing activities | −884,000 | −2 | −173,000 | 5 | −8 | |
| Proceeds from the Term Loan Facility | 40 | 0 | — | — | — | |
| Payments of transaction costs related to the Loan Agreement | −774,000 | 0 | −1 | — | — | |
| Payments of costs related to public offering | −340,000 | −350,000 | 0 | — | — | |
| Payments on revenue interest liability | −45,000 | 0 | — | — | — | |
| Settlement of the Purchase Agreement | −88 | 0 | — | — | — | |
| Proceeds from the Purchase Agreement, net of issuance costs | 0 | 20 | 39 | 0 | — | |
| Payments of transaction costs related to the Purchase Agreement | 0 | −500,000 | −1 | 0 | — | |
| Proceeds from the exercise of stock options | 61,000 | 2 | 566,000 | 535,000 | 598,000 | |
| Proceeds from the JDRF Agreement | 175,000 | 240,000 | 80,000 | 0 | — | |
| Payments of finance lease principal | −3 | −3 | −2 | −2 | −2 | |
| Net cash provided by financing activities | 61 | 114 | 5 | −1 | 267 | |
| Net increase (decrease) in cash, cash equivalents and restricted cash | −44 | 14 | −69 | −68 | 178 | |
| Unpaid transaction costs related to the Loan Agreement | 446,000 | 0 | — | — | — | |
| Increase in right-of-use assets and lease liabilities resulting from lease remeasurement | 15 | 0 | — | — | — | |
| Accrual of transaction costs associated with public offering | 156,000 | 0 | — | — | — | |
| Debt discount from embedded contingent derivative liability | 0 | 2 | 2 | — | — | |
| Issuance of commitment shares pursuant to the Common Stock Purchase Agreement | 0 | 708,000 | 0 | — | — |