LEXICON PHARMACEUTICALS, INC.
Business
LEXICON PHARMACEUTICALS, INC. is a biopharmaceutical company developing and commercializing orally‑delivered small molecule medicines for cardiometabolic and neurological conditions. Its main products and drug candidates include the approved INPEFA® (sotagliflozin) for heart failure and development-stage candidates pilavapadin (LX9211) for neuropathic pain, LX9851 for obesity, and additional sotagliflozin indications. The company operates research and development, regulatory and commercial functions and pursues collaborations and licensing arrangements, while relying on third‑party contract manufacturers for production. It principally commercializes INPEFA in the United States through wholesalers, pharmacies, hospitals and other healthcare distributors and seeks regulatory approvals and partners for other territories.
Summary from filing dated 2025-03-07
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Royalties and other revenue | 156,000 | 80,000 | 94,000 | 139,000 | 298,000 | |
| Total revenues | 50 | 31 | 1 | 139,000 | 298,000 | |
| Cost of sales | 274,000 | 616,000 | 85,000 | 0 | 0 | |
| Research and development | 61 | 84 | 59 | 53 | 55 | |
| Selling, General and Administrative Expense | 37 | 143 | 114 | 48 | 32 | |
| Total operating expenses | 99 | 228 | 173 | 101 | 87 | |
| Loss from operations | −49 | −197 | −172 | −101 | −87 | |
| Interest and other expense | −8 | −16 | −13 | −3 | −802,000 | |
| Interest income and other | 7 | 12 | 8 | 2 | 134,000 | |
| Net loss | −50 | −200 | −177 | −102 | −88 | |
| Net loss per common share, basic (usd per share) | −0.14 | −0.63 | −0.8 | −0.62 | −0.6 | |
| Net loss per common share, diluted (usd per share) | −0.14 | −0.63 | −0.8 | −0.62 | −0.6 | |
| Shares used in computing net loss per common share, basic | 363 | 320 | 221 | 166 | 146 | |
| Shares used in computing net loss per common share, diluted | 363 | 320 | 221 | 166 | 146 | |
| Unrealized (loss) gain on investments | −89,000 | 88,000 | 459,000 | −418,000 | −4,000 | |
| Comprehensive loss | −50 | −200 | −177 | −102 | −88 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 34 | 67 | 22 | 46 | 64 | |
| Short-term investments | 62 | 171 | 148 | 92 | 23 | |
| Accounts receivable, net | 2 | 3 | 1 | 28,000 | 14,000 | |
| Inventory | 281,000 | 231,000 | 381,000 | 0 | — | |
| Prepaid expenses and other current assets | 3 | 5 | 5 | 2 | 2 | |
| Total current assets | 102 | 246 | 177 | 141 | 89 | |
| Property and equipment, net | 2 | 2 | 2 | 2 | 1 | |
| Goodwill | 45 | 45 | 45 | 45 | 45 | |
| Operating lease right-of-use-assets | 7 | 5 | 6 | 6 | — | |
| Restricted cash | 29 | 0 | — | — | — | |
| Other assets | 368,000 | 368,000 | 828,000 | 412,000 | 2 | |
| Total assets | 185 | 298 | 229 | 194 | 137 | |
| Accounts payable | 3 | 15 | 14 | 10 | 9 | |
| Accrued liabilities | 13 | 30 | 17 | 13 | 13 | |
| Current portion of long-term debt | 5 | 0 | — | — | 0 | |
| Total current liabilities | 21 | 45 | 32 | 23 | 22 | |
| Long-term debt, net | 49 | 100 | 100 | 49 | 0 | |
| Other long-term liabilities | 7 | 7 | 5 | 5 | 1 | |
| Total liabilities | 77 | 152 | 136 | 77 | 23 | |
| Commitments and contingencies (Note 10) | — | — | — | — | — | |
| Preferred stock, $0.01 par value; 5,000,000 shares authorized; 2,304,147 Series A Convertible Preferred shares issued and none outstanding | 0 | 0 | 0 | 0 | 0 | |
| Common stock, $0.001 par value; 450,000,000 shares authorized; 365,848,216 and 363,020,303 shares issued, respectively | 366,000 | 363,000 | 245,000 | 189,000 | 150,000 | |
| Additional paid-in capital | 2,130 | 2,117 | 1,863 | 1,709 | 1,609 | |
| Accumulated deficit | −2,018 | −1,967 | −1,767 | −1,590 | −1,488 | |
| Accumulated other comprehensive income | 30,000 | 119,000 | 31,000 | −428,000 | −10,000 | |
| Treasury stock, at cost, 2,381,939 and 1,528,008 shares, respectively | −5 | −5 | −3 | −2 | −8 | |
| Total stockholders' equity | 108 | 146 | 93 | 117 | 114 | |
| Total liabilities and stockholders equity | 185 | 298 | 229 | 194 | 137 | |
| Preferred stock, shares outstanding | 0 | 0 | 0 | 0 | 0 | |
| Common Stock, Shares, Outstanding | 366 | 363 | — | — | — |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation and amortization | 621,000 | 534,000 | 554,000 | 427,000 | 292,000 | |
| Stock-based compensation | 13 | 13 | 14 | 12 | 11 | |
| Amortization of debt-related costs | 2 | 2 | 2 | 741,000 | 54,000 | |
| Accretion of marketable securities purchased at a discount | −4 | −9 | −6 | 0 | — | |
| Other non-cash adjustments | −2 | 812,000 | 2 | 0 | — | |
| Decrease (increase) in accounts receivable | 1 | −2 | −982,000 | −14,000 | 381,000 | |
| (Increase) decrease in inventories | −50,000 | 150,000 | −381,000 | 0 | 0 | |
| Decrease (increase) in prepaid expenses and other current assets | 2 | 598,000 | −3 | −316,000 | 3 | |
| Decrease in other long-term assets | 757,000 | 1 | 467,000 | 656,000 | 661,000 | |
| (Decrease) increase in accounts payable and other liabilities | −30 | 15 | 6 | 76,000 | −14 | |
| Net cash used in operating activities | −68 | −179 | −162 | −89 | −87 | |
| Purchases of property and equipment | 0 | −1 | −470,000 | −1 | −1 | |
| Purchases of investments | −140 | −329 | −223 | −134 | −34 | |
| Maturities of investments | 253 | 314 | 174 | 64 | 38 | |
| Net cash provided by (used in) investing activities | 113 | −15 | −50 | −71 | 2 | |
| Proceeds from issuance of common stock, net of fees | 0 | 0 | 139 | 94 | 37 | |
| Proceeds from issuance of common stock for equity incentive plans | 73,000 | 64,000 | 0 | 0 | — | |
| Proceeds from issuance of preferred stock, net of fees | 0 | 241 | 0 | 0 | — | |
| Payments for tax withholding on share-based compensation vesting | −572,000 | −2 | −824,000 | — | — | |
| Debt payments | −48 | 0 | 0 | — | — | |
| Proceeds from debt borrowings, net of fees | 0 | 0 | 50 | 49 | — | |
| Other debt financing fees | 0 | −1 | 0 | 0 | — | |
| Net cash (used in) provided by financing activities | −48 | 238 | 188 | 142 | 23 | |
| Net (decrease) increase in cash, cash equivalents, and restricted cash | −3 | 44 | −24 | −18 | −62 | |
| Cash paid for interest | 8 | 13 | 10 | 2 | 799,000 | |
| Right-of-use assets obtained in exchange for operating lease obligations | 3 | 0 | 0 | 5 | 2 | |
| Accrual of deferred financing costs | 0 | 0 | 250,000 | 0 | 0 | |
| Conversion of preferred stock to common stock | 0 | 115,000 | 0 | 0 | — |