MeiraGTx Holdings plc
Business
MeiraGTx Holdings plc is a vertically integrated, clinical-stage genetic medicines company developing gene therapies using adeno-associated viral vectors for inherited retinal diseases, neurodegenerative disorders, and salivary gland dysfunction. The company offers a pipeline of late-stage clinical programs including AAV-hAQP1 for radiation-induced xerostomia, AAV-GAD for Parkinson's disease, and AAV-AIPL1 for Leber congenital amaurosis 4, alongside a proprietary riboswitch gene regulation platform for dose-responsive transgene control. MeiraGTx operates GMP-certified manufacturing facilities in London and Shannon for internal production of viral vectors, plasmid DNA, and quality control, serving its clinical programs and supply agreements with partners including Johnson & Johnson and Eli Lilly.
Summary from 10-K filed 2026-03-30
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenue | 81 | 33 | 14 | — | — | |
| Cost of service revenue - related party | 5 | 24 | — | — | — | |
| General and administrative | 53 | 54 | 47 | 47 | 44 | |
| Research and development | 130 | 119 | 104 | 86 | 67 | |
| Total operating expenses | 187 | 197 | 151 | 132 | 110 | |
| Loss from operations | −106 | −164 | −137 | −116 | −73 | |
| Foreign currency gain (loss) | 2 | −3 | 9 | −9 | 6 | |
| Interest income | 2 | 4 | 2 | 777,000 | 212,000 | |
| Interest expense | −12 | −13 | −13 | −5 | −288,000 | |
| Gain on sale of nonfinancial assets | — | 28 | 54 | — | — | |
| Net loss | −114 | −148 | −84 | −130 | −80 | |
| Foreign currency translation gain (loss) | 6 | −2 | −7 | 9 | 2 | |
| Comprehensive loss | −108 | −150 | −92 | −121 | −77 | |
| Net loss | −114 | −148 | −84 | −130 | −80 | |
| Basic net loss per ordinary share | −1.42 | −2.12 | −1.49 | −2.87 | −1.8 | |
| Diluted net loss per ordinary share | −1.42 | −2.12 | −1.49 | −2.87 | −1.8 | |
| Weighted-average number of ordinary shares outstanding, basic | 80 | 70 | 56 | 45 | 44 | |
| Weighted-average number of ordinary shares outstanding, diluted | 80 | 70 | 56 | 45 | 44 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 66 | 104 | 130 | 116 | 138 | |
| Accounts receivable - related party | 3 | 707,000 | 10 | 21 | — | |
| Contract assets - related party | — | 950,000 | — | — | — | |
| Inventory | — | 385,000 | — | — | — | |
| Prepaid expenses | 6 | 7 | 6 | 8 | 8 | |
| Tax incentive receivable | 15 | 9 | 13 | 8 | — | |
| Other current assets | 2 | 2 | 1 | 2 | 2 | |
| Total Current Assets | 92 | 124 | 160 | 154 | 183 | |
| Property, plant and equipment, net | 105 | 103 | 116 | 109 | 76 | |
| Intangible assets, net | 578,000 | 821,000 | 1 | 1 | 2 | |
| Restricted cash | 2 | 2 | 1 | — | — | |
| Other assets | 1 | 1 | 2 | 1 | 1 | |
| Equity method and other investments | 7 | 7 | 7 | 6 | — | |
| Right-of-use assets - operating leases, net | 13 | 11 | 16 | 20 | 23 | |
| Right-of-use assets - finance leases, net | 24 | 22 | 24 | 25 | 28 | |
| TOTAL ASSETS | 244 | 270 | 327 | 318 | 320 | |
| Accounts payable | 10 | 24 | 16 | 17 | 15 | |
| Accrued expenses | 33 | 27 | 43 | 40 | 28 | |
| Lease obligations - operating leases, current | 3 | 4 | 4 | 4 | 3 | |
| Lease obligations - finance leases, current | 38,000 | — | — | — | — | |
| Deferred revenue - related party, current | 2 | 5 | 3 | 15 | — | |
| Note payable, net, current | 25 | — | — | — | — | |
| Other current liabilities | 50 | 903,000 | 1 | 7 | — | |
| Total Current Liabilities | 123 | 61 | 67 | 82 | 68 | |
| Deferred revenue - related party | 65 | 58 | 34 | 27 | — | |
| Lease obligations - operating leases | 11 | 8 | 13 | 17 | 20 | |
| Lease obligations - finance leases | 109,000 | — | — | — | — | |
| Asset retirement obligations | 1 | 3 | 2 | 2 | 2 | |
| Note payable, net | 50 | 73 | 72 | 71 | — | |
| TOTAL LIABILITIES | 250 | 202 | 189 | 200 | 135 | |
| COMMITMENTS AND CONTINGENCIES (Note 15) | — | — | — | — | — | |
| Ordinary Shares, $0.00003881 par value, 1,288,327,750 authorized, 81,120,931 and 78,397,380 shares issued and outstanding at December 31, 2025 and 2024, respectively | 3,000 | 3,000 | 2,000 | 2,000 | 2,000 | |
| Capital in excess of par value | 808 | 774 | 694 | 582 | 529 | |
| Accumulated other comprehensive gain (loss) | 2 | −4 | −1 | 6 | −3 | |
| Accumulated deficit | −816 | −702 | −554 | −470 | −341 | |
| Total Shareholders' (Deficit) Equity | −6 | 68 | 138 | 118 | 185 | |
| TOTAL LIABILITIES AND SHAREHOLDERS' (DEFICIT) EQUITY | 244 | 270 | 327 | 318 | 320 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −114 | −148 | −84 | −130 | −80 | |
| Share-based compensation expense | 22 | 25 | 28 | 29 | 21 | |
| Depreciation and amortization | 13 | 13 | 14 | 9 | 8 | |
| Change in right-of-use assets | 7 | 4 | — | — | — | |
| Gain on termination of lease liabilities | −1 | −172,000 | — | — | — | |
| Loss on disposal of equipment, furniture and fixtures | 355,000 | 9,000 | — | — | 56,000 | |
| Loss on equity method investment | — | 17,000 | 6,000 | — | 9,000 | |
| Amortization of interest on asset retirement obligations | 153,000 | 209,000 | 177,000 | 168,000 | — | |
| Amortization of debt discount | 1 | 1 | 1 | 444,000 | — | |
| Acquired in-process research and development | 568,000 | — | 1 | — | — | |
| Accounts receivable - related party | −2 | 6 | 10 | 1 | 16 | |
| Contract assets - related party | 986,000 | −954,000 | — | — | — | |
| Inventory | 428,000 | −387,000 | — | — | — | |
| Prepaid expenses | 720,000 | −1 | 3 | −329,000 | −1 | |
| Tax incentive receivable | −6 | 4 | −5 | 4 | — | |
| Other current assets | −365,000 | −2 | 222,000 | 519,000 | 2 | |
| Other assets, net | −159,000 | 759,000 | −2 | −173,000 | — | |
| Accounts payable | −12 | 11 | 2 | 4 | 13 | |
| Accrued expenses | 4 | −14 | −382,000 | 13 | 8 | |
| Change in lease liabilities | −6 | −4 | — | — | — | |
| Other current liabilities | 50 | 32,000 | −1 | 4 | −23,000 | |
| Deferred revenue - related party | −731,000 | 27 | −8 | −16 | −7 | |
| Net cash used in operating activities | −46 | −104 | −105 | −73 | −11 | |
| Purchase of property, plant and equipment | −4 | −5 | −20 | −45 | −46 | |
| Acquisition of in-process research and development assets | −410,000 | — | — | — | — | |
| Proceeds from sale of equipment, furniture and fixtures | 129,000 | — | — | — | — | |
| Proceeds from sale of nonfinancial assets | — | 28 | 54 | — | — | |
| Net cash (used in) provided by investing activities | −4 | 23 | 34 | −45 | −62 | |
| Exercise of share options | 257,000 | — | 10,000 | 231,000 | 2 | |
| Payments of withholdings on shares withheld for income taxes | −3 | −2 | −2 | −3 | — | |
| Payments on lease obligations - financing leases | −29,000 | — | — | — | −1,000 | |
| Proceeds from the issuance of ordinary shares | 15 | 59 | 92 | 25 | — | |
| Issuance costs in connection with ordinary shares | −39,000 | −3 | −6 | — | — | |
| Net cash provided by financing activities | 12 | 55 | 84 | 95 | 2 | |
| Net decrease in cash, cash equivalents and restricted cash | −38 | −26 | 13 | −23 | −71 | |
| Effect of exchange rate changes on cash, cash equivalents and restricted cash | 719,000 | 2 | 2 | 674,000 | −1 | |
| Fixed asset acquisitions included in accounts payable and accrued expenses | 1 | 851,000 | 3 | 7 | — | |
| Right-of-Use Asset Obtained in Exchange for Operating Lease Liability | 9 | — | — | 2 | — | |
| Right-of-use assets obtained in exchange for lease liabilities | 9 | — | — | — | — | |
| Change in estimate of asset retirement obligation | −2 | 345,000 | — | — | — | |
| Reversal of issuance costs | 50,000 | — | — | — | — | |
| Cash paid for interest | 11 | 12 | 13 | 329,000 | 139,000 |
Filings
Material Events
Insiders
Institutional Holders
Frequently asked questions
What is MeiraGTx Holdings plc's CIK number?
MeiraGTx Holdings plc's SEC CIK number is 0001735438 (1735438). The CIK (Central Index Key) is the permanent identifier the SEC assigns to every EDGAR filer — unlike a ticker symbol, it never changes.
Where can I find MeiraGTx Holdings plc's SEC filings?
All of MeiraGTx Holdings plc's EDGAR filings — 10-K annual reports, 10-Q quarterly reports, 8-K material events, and insider transactions — are listed on this page, sourced live from SEC EDGAR.
When did MeiraGTx Holdings plc last report earnings?
MeiraGTx Holdings plc (MGTX) most recently filed an earnings 8-K with the SEC on May 14, 2026, furnishing its results under Item 2.02 (Results of Operations and Financial Condition). The earnings press release is attached to that filing (accession 0001104659-26-060726). This is MeiraGTx Holdings plc's most recent earnings filing of record — not a forecast of its next earnings date.
What is MeiraGTx Holdings plc's most recent earnings 8-K?
MeiraGTx Holdings plc's latest earnings 8-K (Item 2.02) was filed May 14, 2026 under accession 0001104659-26-060726. It carries the quarterly or annual earnings press release — the earliest official, SEC-filed version of the results.
View MeiraGTx Holdings plc's latest earnings 8-K →
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