Passage BIO, Inc.
Business
Passage Bio, Inc. is a clinical-stage genetic medicines company developing one-time gene therapies to address neurodegenerative diseases, with an emphasis on central nervous system disorders. Its main product is PBFT02, an AAV1-based gene replacement therapy delivered via intra cisterna magna to elevate progranulin; other programs include a preclinical Huntington’s program and previously outlicensed pediatric programs. Key business activities include clinical development, research collaborations and licensing arrangements, and manufacturing and analytical operations supported by third-party partners. It conducts international, multi-center clinical trials and pursues regulatory interactions and distribution across the U.S., Europe and other countries.
Summary from filing dated 2025-03-04
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 23 | 40 | 61 | — | — | |
| General and administrative | 20 | 25 | 42 | 49 | 60 | |
| Impairment of long-lived assets | 6 | 5 | 5 | — | — | |
| Loss from operations | −49 | −70 | −108 | −138 | −186 | |
| Other income (expense), net | 4 | 6 | 6 | 2 | — | |
| Net loss | −46 | −65 | −102 | −136 | −185 | |
| Net loss per share of common stock, basic | −14.35 | −21.04 | −1.86 | −2.5 | −3.48 | |
| Net loss per share of common stock, diluted | −14.35 | −21.04 | −1.86 | −2.5 | −3.48 | |
| Weighted average common shares outstanding, basic | 3 | 3 | 55 | 54 | 53 | |
| Weighted average common shares outstanding, diluted | 3 | 3 | 55 | 54 | 53 | |
| Unrealized gain (loss) on marketable securities | −8,000 | 51,000 | 923,000 | −553,000 | −401,000 | |
| Comprehensive loss | −46 | −65 | −101 | −137 | −186 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 46 | 38 | 22 | 35 | 129 | |
| Marketable securities | 0 | 39 | 93 | 155 | 187 | |
| Prepaid expenses and other current assets | 629,000 | 838,000 | 923,000 | 926,000 | 2 | |
| Prepaid research and development | 830,000 | 1 | 3 | 7 | 8 | |
| Total current assets | 48 | 79 | 118 | 197 | 325 | |
| Property and equipment, net | 4 | 9 | 15 | 23 | 24 | |
| Right of use assets - operating leases | 10 | 14 | 17 | 20 | — | |
| Other assets | 244,000 | 463,000 | 433,000 | 4 | 6 | |
| Total assets | 62 | 102 | 151 | 244 | 355 | |
| Accounts payable | 1 | 742,000 | 1 | 4 | 9 | |
| Accrued expenses and other current liabilities | 5 | 7 | 12 | 11 | 20 | |
| Non-refundable sublicense and transition services payments | 14 | 8 | — | — | — | |
| Operating lease liabilities | 4 | 4 | 3 | 3 | — | |
| Total current liabilities | 23 | 19 | 16 | 18 | 29 | |
| Operating lease liabilities - noncurrent | 20 | 22 | 23 | 24 | — | |
| Total liabilities | 44 | 41 | 39 | 42 | 36 | |
| Commitments and contingencies (note 11) | — | — | — | — | — | |
| Preferred stock, $0.0001 par value: 10,000,000 shares authorized; no shares issued and outstanding at both December 31, 2025 and December 31, 2024 | — | — | — | — | — | |
| Additional paidin capital | 724 | 720 | 706 | 695 | 675 | |
| Accumulated other comprehensive income (loss) | — | 8,000 | −43,000 | −966,000 | −413,000 | |
| Accumulated deficit | −705 | −659 | −594 | −492 | −356 | |
| Total stockholders' equity | 19 | 61 | 111 | 201 | 319 | |
| Total liabilities and stockholders' equity | 62 | 102 | 151 | 244 | 355 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation and amortization | 700,000 | 3 | 4 | 4 | 2 | |
| Sharebased compensation | 3 | 6 | 11 | 19 | 33 | |
| Amortization of premium and discount on marketable securities, net | 129,000 | −2 | −2 | 773,000 | 3 | |
| Other non-cash items | 14,000 | — | — | — | — | |
| Prepaid expenses and other current assets, and other assets | 228,000 | 255,000 | 4 | 3 | 2 | |
| Prepaid research and development | 391,000 | 2 | 4 | 1 | 3 | |
| Non-refundable sublicense and transition services payments received | 4 | 8 | — | — | — | |
| Right of use assets and operating lease liabilities | −464,000 | −279,000 | −133,000 | 463,000 | — | |
| Accounts payable | 2 | −556,000 | −3 | −5 | 2 | |
| Accrued expenses and other current liabilities | −2 | −5 | 659,000 | −7 | — | |
| Net cash provided by (used in) operating activities | −32 | −48 | −78 | −118 | −127 | |
| Purchases of marketable securities | — | −88 | −129 | −158 | −203 | |
| Sales or maturities of marketable securities | 39 | 143 | 195 | 188 | 182 | |
| Purchases of property and equipment and other assets | — | −34,000 | — | — | — | |
| Sales of property and equipment and other assets | 1 | — | — | — | — | |
| Net cash provided by (used in) investing activities | 40 | 55 | 65 | 25 | −46 | |
| Proceeds from issuance of common stock under the ATM Facility, net of offering costs | — | 9 | — | — | — | |
| Proceeds from the exercise of stock options | — | 35,000 | — | 129,000 | 301,000 | |
| Proceeds from the issuance of common stock under employee stock purchase plan | 23,000 | 97,000 | 135,000 | 304,000 | 887,000 | |
| Net cash provided by (used in) financing activities | 23,000 | 9 | 135,000 | −1 | 167 | |
| Net increase (decrease) in cash and cash equivalents | 9 | 16 | −13 | −94 | −6 | |
| Unrealized gain (loss) on marketable securities | −8,000 | 51,000 | 923,000 | −553,000 | −401,000 | |
| Right of use assets recognized upon the commencement of sublease | — | −422,000 | — | −20 | — | |
| Operating lease liabilities recognized upon the commencement of sublease | — | 422,000 | — | 27 | — |