Transcode Therapeutics, Inc.
Business
Transcode Therapeutics, Inc. is an RNA oncology company that designs and delivers RNA therapeutics to tumors and metastatic sites using its proprietary TTX drug design engine. It develops therapeutic candidates including TTX-MC138 (an antisense oligonucleotide targeting miR-10b), TTX-siPDL1 (an siRNA modulating PD-L1), TTX-RIGA (a RIG‑I agonist) and TTX‑siMYC, and supports radiolabeled and other payload formats. Its activities span discovery, preclinical studies and early clinical trials as distinct programmatic efforts. The company conducts clinical development primarily in the United States and leverages academic collaborations, contract manufacturers and global licensing and commercialization channels.
Summary from filing dated 2025-04-15
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 13 | 10 | 12 | 10 | 3 | |
| General and administrative expenses | 6 | 6 | 7 | 8 | 3 | |
| Acquisition-related transaction costs | 9 | — | — | — | — | |
| Total general and administrative | 15 | 6 | — | — | — | |
| Total operating expenses | 28 | 16 | 19 | 19 | 6 | |
| Operating loss | −28 | −16 | −19 | −19 | −6 | |
| Change in fair value of warrant liabilities | −9 | −938,690 | — | — | −6,109 | |
| Change in fair value of contingent consideration | 2 | — | — | — | — | |
| PIPE warrant Issuance Costs | — | −596,957 | — | — | — | |
| Grant income | 1 | 524,064 | 923,035 | 1 | 278,333 | |
| Gain on sale of equipment | — | 500 | — | — | −3,082 | |
| Currency exchange gain (loss) | −112,065 | −57,062 | — | — | — | |
| Interest income | 79,198 | 684 | 5,285 | 20,410 | 664 | |
| Interest expense | −6,616 | −26,813 | — | — | — | |
| Total other income (expense) | −6 | −1 | 872,421 | 1 | −692,264 | |
| Loss before income taxes | −34 | −17 | — | — | — | |
| Deferred income tax provision | −226,068 | — | — | — | — | |
| Net Loss | −35 | −17 | −19 | −18 | −7 | |
| Deemed dividend arising from warrant modification | — | −30,601 | — | — | — | |
| Accrual of paid-in-kind dividends on Series A Non-Voting Convertible Preferred Stock | −2 | — | — | — | — | |
| Net loss attributable to common stockholders | −36 | −17 | −19 | — | — | |
| Net loss attributable to common stockholders, diluted | −36 | −17 | −19 | — | — | |
| Weighted-average common shares outstanding, Basic | 689,713 | 12,558 | 5,424 | 16,222 | 8 | |
| Weighted-average common shares outstanding, Diluted | 689,713 | 12,558 | 5,424 | 16,222 | 8 | |
| Net loss per share, Basic | −52.59 | −1,337 | −3,419 | −1,083 | −0.81 | |
| Net loss per share, Diluted | −52.59 | −1,337 | −3,419 | −1,083 | −0.81 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash | 18 | 6 | 3 | 5 | 21 | |
| Grant receivable | 952,460 | 0 | — | 360,229 | — | |
| Reimbursement right | 2 | — | — | — | — | |
| Due from related party | 638 | — | — | — | — | |
| Prepaid expenses and other current assets | 919,440 | 1 | 2 | 2 | 2 | |
| Total current assets | 22 | 7 | 4 | 7 | 23 | |
| Property and equipment, net of depreciation | 370,681 | 51,574 | 120,707 | 208,581 | 206,268 | |
| Goodwill | 26 | — | — | — | — | |
| In-process research and development, carrying value | 114 | — | — | — | — | |
| Right-of-use asset, net of amortization | — | 37,731 | 481,694 | — | — | |
| Security deposit | — | 111,856 | 111,856 | — | — | |
| Total assets | 162 | 7 | 5 | 8 | 23 | |
| Accounts payable and accrued expenses | 3 | 3 | 3 | 4 | 3 | |
| Deferred grant income | 0 | 25,408 | 27,057 | 0 | 30,528 | |
| Short-term lease liability | — | 38,291 | 412,280 | — | — | |
| Total current liabilities | 3 | 3 | 3 | 4 | 3 | |
| Contingent Consideration | 6 | — | — | — | — | |
| Deferred tax liability | 226,068 | — | — | — | — | |
| Long-term liabilities | 7 | 7 | 38,291 | — | — | |
| Total liabilities | 11 | 9 | 4 | 4 | 3 | |
| Commitments and contingencies | — | — | — | — | — | |
| Common stock - $0.0001 par value, 290,000,000 shares authorized at December 31, 2025 and 2024; 916,968 and 36,753 shares issued and outstanding at December 31, 2025 and 2024, respectively | 92 | 4 | 2 | 2 | 1,291 | |
| Additional paid-in capital | 108 | 61 | 48 | 31 | 31 | |
| Accumulated deficit | −98 | −63 | −46 | −28 | −10 | |
| Total stockholders' equity (deficit) | 10 | −2 | 2 | 3 | 20 | |
| Total liabilities, Series A Non-Voting Convertible Preferred Stock and stockholders' equity (deficit) | 162 | 7 | 5 | 8 | 23 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −35 | −17 | −19 | −18 | −7 | |
| Depreciation | 76,446 | 90,894 | 123,483 | 98,606 | 42,470 | |
| Amortization of right-of-use asset | 37,731 | 443,963 | 393,263 | — | — | |
| Non-cash transaction costs | 7 | — | — | — | — | |
| Share-based compensation expense | 485,428 | 2 | 1 | 395,329 | 185,996 | |
| Due from related parties | −638 | — | — | — | — | |
| Prepaid expenses and other current assets | 477,261 | 405,573 | 362,912 | −144,444 | −2 | |
| Accounts payable and accrued expenses | 216,541 | −343,123 | −1 | 2 | 2 | |
| Deferred grant income | −25,408 | −1,649 | 27,057 | −30,528 | 30,528 | |
| Grants receivable | −952,460 | — | 360,229 | −360,229 | — | |
| Security deposit | 111,856 | — | −111,856 | — | — | |
| Operating lease liability | −38,291 | −412,280 | −424,385 | — | — | |
| Deferred Tax Liability | 226,068 | — | — | — | — | |
| Net cash used in operating activities | −20 | −13 | −18 | −16 | −5 | |
| Cash acquired through the acquisition of Polynoma | 2,224 | — | — | — | — | |
| Purchase of equipment | −6,660 | −21,761 | −35,609 | −100,919 | −254,820 | |
| Net cash used in investing activities | −4,436 | −21,761 | −35,609 | −100,919 | −251,820 | |
| Proceeds from offering of preferred stock (Series B), net of offering costs | 23 | — | — | — | — | |
| Net proceeds from sales of common stock | 9 | 16 | 16 | — | — | |
| Net cash provided by financing activities | 32 | 16 | 16 | 5,989 | 26 | |
| Net change in cash | 12 | 3 | −2 | −16 | 20 | |
| Interest related to insurance premium payment plan | 6,501 | 16,629 | 32,861 | 37,115 | 17,870 | |
| Exercise of Series D warrants | 15 | — | — | — | — | |
| Accrual of paid-in-kind dividends on Series A Non-Voting Convertible Preferred Stock | 2 | — | — | — | — | |
| Preferred stock issued in connection with acquisition of Polynoma | 133 | — | — | — | — | |
| Common stock issued in connection with acquisition of Polynoma | 1 | — | — | — | — |