SAB Biotherapeutics, Inc.
Business
SAB Biotherapeutics, Inc. is a clinical-stage biopharmaceutical company developing human polyclonal immunotherapeutic antibodies (hIgG) to treat immune-mediated disorders. Its main products and services include target-specific, polyclonal hIgG therapeutics produced via a proprietary transchromosomic (Tc) Bovine platform, with lead candidate SAB-142, a human anti-thymocyte globulin for type 1 diabetes. Key business activities encompass therapeutic discovery and development, a clinical-stage pipeline, and in-house plasma fractionation and GMP manufacturing capabilities. The company pursues regulatory interactions and clinical development across multiple jurisdictions, supporting global clinical trials and regulatory filings.
Summary from filing dated 2025-03-31
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenue | 0 | 1 | 2 | 24 | 61 | |
| Research and development | 34 | 30 | 17 | 36 | 57 | |
| General and administrative | 15 | 14 | 24 | 16 | 17 | |
| Total operating expenses | 49 | 44 | 40 | 53 | 74 | |
| Loss from operations | −49 | −43 | −38 | −29 | −13 | |
| Changes in fair value of warrant liabilities | 63 | 5 | −5 | 10 | −4 | |
| Interest expense | −240,664 | −318,401 | −315,284 | — | — | |
| Interest income | 1 | 1 | 584,966 | 71,072 | 23,115 | |
| Other income | 3 | 2 | 435,089 | 33,754 | — | |
| Warrant issuance expense | −5 | 0 | — | — | — | |
| Total other income | 62 | 9 | −4 | 10 | −4 | |
| Net income (loss) | 13 | −34 | −42 | −19 | −17 | |
| Unrealized gain, change in fair value of available-for-sale securities, net of tax | 185,464 | 647 | — | — | — | |
| Foreign currency translation gain (loss) | 136,456 | −162,477 | 26,420 | — | — | |
| Total comprehensive income (loss) | 14 | −34 | −42 | −19 | — | |
| Basic income (loss) per common share | 0.22 | −3.68 | −7.64 | −4.31 | −0.63 | |
| Diluted loss per common share | −0.79 | −3.68 | −7.64 | −4.31 | −0.63 | |
| Weighted-average common shares outstanding - basic | 19 | 9 | 6 | 4 | 27 | |
| Weighted-average common shares outstanding - diluted | 61 | 9 | 6 | 4 | 27 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2022 2022-06-30 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 11 | 9 | 57 | 15 | 17 | |
| Short-term investments | 86 | 12 | 0 | — | — | |
| Accrued interest receivable | 900,000 | 100,000 | 0 | — | — | |
| Prepaid expenses and other current assets | 4 | 3 | 2 | 1 | — | |
| Total current assets | 101 | 24 | 59 | 22 | 28 | |
| Deferred issuance cost | 200,000 | 300,000 | 0 | — | — | |
| Long-term prepaid assets | 5 | 220,997 | 350,230 | 467,694 | 535,082 | |
| Long-term investments | 47 | — | — | — | — | |
| Operating lease right-of-use assets | 3 | 970,294 | 1 | 1 | 2 | |
| Financing lease right-of-use assets | 3 | 4 | 4 | 4 | 4 | |
| Property, plant and equipment, net | 13 | 15 | 20 | 23 | 25 | |
| Total assets | 173 | 44 | 84 | 51 | 59 | |
| Accounts payable | 3 | 2 | 945,927 | 4 | 5 | |
| Notes payable | 0 | 275,849 | 1 | 772,665 | 278,441 | |
| Accrued expenses and other current liabilities | 7 | 5 | 7 | 10 | 10 | |
| Operating lease liabilities, current portion | 797,402 | 393,430 | 669,946 | 490,794 | 1 | |
| Finance lease liabilities, current portion | 153,967 | 142,563 | 132,004 | 132,788 | 140,767 | |
| Total current liabilities | 11 | 8 | 11 | 15 | 16 | |
| Operating lease liabilities, noncurrent | 2 | 581,148 | 635,777 | 361,225 | 1 | |
| Finance lease liabilities, noncurrent | 3 | 3 | 3 | 4 | 4 | |
| Warrant liabilities | 6 | 6 | 12 | 320,930 | 1 | |
| Total liabilities | 21 | 18 | 27 | 20 | 22 | |
| Commitments and contingencies (Note 18) | — | — | — | — | — | |
| Common stock; $0.0001 par value; 800,000,000 shares authorized at December 31, 2025 and December 31, 2024; 47,664,564 and 9,343,533 shares issued at December 31, 2025 and December 31, 2024, respectively, and 47,609,899 and 9,288,868 outstanding at December 31, 2025 and December 31, 2024, respectively | 4,766 | 935 | 929 | 510 | 4,358 | |
| Treasury stock, at cost; 54,665 shares held at December 31, 2025 and December 31, 2024, respectively | −6 | −6 | −6 | −6 | −6 | |
| Additional paid-in capital | 268 | 156 | 153 | 84 | 76 | |
| Accumulated other comprehensive income (loss) | 186,510 | −135,410 | 26,420 | — | — | |
| Accumulated deficit | −111 | −124 | −90 | −48 | −33 | |
| Total stockholders' equity | 151 | 26 | 57 | 31 | 37 | |
| Total liabilities and stockholders' equity | 173 | 44 | 84 | 51 | 59 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation and amortization | 3 | 5 | 4 | 3 | 1 | |
| Amortization of finance right-of-use assets | 100,000 | 100,000 | 100,000 | 100,000 | — | |
| Stock-based compensation expense | 5 | 3 | 2 | 3 | 2 | |
| Net realized and unrealized gain on investment in short-term securities | −73,967 | — | — | — | — | |
| Accretion of discounts on short-term investments | −88,631 | −237,093 | — | — | — | |
| Write-off of deferred issuance costs | 261,105 | — | — | — | — | |
| Accrued interest receivable | −891,826 | −54,955 | — | — | — | |
| Prepaid expenses and other current assets | −5 | −590,461 | −523,610 | — | — | |
| Operating lease right-of-use assets and liabilities, net | 67,420 | −23,458 | 387,299 | — | — | |
| Accounts payable | 1 | 923,323 | −3 | −779,425 | −3 | |
| Deferred grant income | — | −1 | 1 | −100,000 | 0 | |
| Accrued expense and other current liabilities | 941,524 | −1 | −2 | −3 | 3 | |
| Net cash used in operating activities | −45 | −34 | −25 | −23 | 2 | |
| Proceeds from the sale of equipment | 500 | — | 44,450 | 76,390 | 0 | |
| Purchases of equipment | −933,156 | −337,262 | −197,154 | −2 | −11 | |
| Purchases of investment securities | −142 | −37 | — | — | — | |
| Sales and maturities of investments | 21 | 26 | — | — | — | |
| Net cash used in investing activities | −122 | −12 | −152,704 | −2 | −11 | |
| Proceeds from the 2025 PIPE, net of Series B issuance costs | 169 | — | — | — | — | |
| Payment of deferred issuance costs | −758 | −261,105 | — | — | — | |
| Proceeds from issuance of notes payable | — | 515,986 | 765,194 | 1 | −3 | |
| Principal payments of notes payable | −275,849 | −1 | −1 | −2 | −1 | |
| Principal payments on finance leases | −142,563 | −132,003 | −126,985 | −161,055 | −203,124 | |
| Proceeds from exercise of stock options | — | 20,409 | 9,582 | 76,971 | 6,750 | |
| Tax payments for share settlement of restricted stock units | −11,205 | −24,931 | — | — | — | |
| Net cash provided by (used in) financing activities | 168 | −1 | 67 | 1 | 36 | |
| Effect of exchange rate changes on cash and cash equivalents | −213,497 | −241,198 | 18,144 | — | — | |
| Net increase (decrease) in cash and cash equivalents | 2 | −48 | 42 | −24 | 27 | |
| Cash paid for interest | 242,032 | 373,954 | 245,481 | 293,392 | 294,459 | |
| Right-of-use assets obtained in exchange for operating lease liabilities | 2 | 368,425 | 993,811 | 65,088 | 505,187 | |
| Deferred issuance costs included in accrued expenses | 149,387 | — | — | — | — | |
| Reclassification of warrants from liability to equity | 91 | — | — | — | — | |
| Reclassification of Redeemable Preferred Stock to Permanent Equity upon Requisite Approval | 16 | — | — | — | — |