SERA PROGNOSTICS, INC.
Business
SERA PROGNOSTICS, INC. is a women’s health company that discovers, develops and commercializes blood-based biomarker tests and predictive analytic products to improve maternal and neonatal health. Its main offerings include the PreTRM test for predicting spontaneous preterm birth and a pipeline of additional biomarker tests, a molecular time-to-birth product, and predictive analytics tools. The company operates through clinical laboratory testing, proteomics and bioinformatics discovery and validation, and commercialization efforts. It distributes tests via clinician-ordered channels, payer collaborations, institutional partners and direct-to-consumer options across the United States and select international collaborations.
Summary from filing dated 2025-03-19
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Revenue | 81,000 | 77,000 | 306,000 | 268,000 | 82,000 | |
| Cost of revenue | 164,000 | 82,000 | 210,000 | — | — | |
| Research and development | 13 | 15 | 15 | 14 | 11 | |
| Selling and marketing | 7 | 6 | 8 | 15 | 10 | |
| General and administrative | 17 | 16 | 16 | 17 | 14 | |
| Total operating expenses | 37 | 37 | 40 | 46 | 35 | |
| Loss from operations | −37 | −37 | −40 | −46 | −35 | |
| Interest expense | −9,000 | −28,000 | −55,000 | — | — | |
| Other income, net | 5 | 4 | 4 | 2 | 1 | |
| Net loss | −32 | −33 | −36 | −44 | −35 | |
| Net loss per share, basic | −0.67 | −0.99 | −1.16 | −1.43 | −2.33 | |
| Net loss per share, diluted | −0.67 | −0.99 | −1.16 | −1.43 | −2.33 | |
| Weighted-average shares outstanding, basic | 48 | 33 | 31 | 31 | 15 | |
| Weighted-average shares outstanding, diluted | 48 | 33 | 31 | 31 | 15 | |
| Unrealized gain on available-for-sale debt securities, net of tax | 202,000 | 75,000 | 966,000 | −798,000 | −183,000 | |
| Total other comprehensive income | 202,000 | 75,000 | 966,000 | −798,000 | −183,000 | |
| Comprehensive loss | −32 | −33 | −35 | −45 | −35 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 4 | 4 | 4 | 30 | 59 | |
| Marketable securities | 35 | 42 | 45 | 53 | 46 | |
| Accounts receivable | 12,000 | 34,000 | 160,000 | 113,000 | 27,000 | |
| Prepaid expenses and other current assets | 2 | 1 | 795,000 | 1 | 2 | |
| Total current assets | 41 | 48 | 61 | 90 | 110 | |
| Property and equipment, net | 1 | 1 | 2 | 3 | 2 | |
| Long-term marketable securities | 57 | 22 | 31 | 21 | 35 | |
| Intangible assets, net | 910,000 | 1 | 0 | — | — | |
| Other assets | 3 | 737,000 | 1 | 2 | 157,000 | |
| Total assets | 102 | 73 | 95 | 116 | 147 | |
| Accounts payable | 862,000 | 2 | 1 | 2 | 1 | |
| Accrued and other current liabilities | 3 | 2 | 3 | 4 | 4 | |
| Finance lease obligation, current portion | 2,000 | 194,000 | 440,000 | 464,000 | 74,000 | |
| Deferred revenue | 20 | 20 | 20 | 9 | 3 | |
| Total current liabilities | 24 | 25 | 24 | 16 | 8 | |
| Finance lease obligation, net of current portion | 0 | 2,000 | 196,000 | 626,000 | 54,000 | |
| Operating lease obligation, net of current portion | 2 | 0 | 644,000 | 1 | 0 | |
| Total liabilities | 27 | 25 | 25 | 17 | 8 | |
| Commitments and contingencies (Note 13) | — | — | — | — | — | |
| Common stock, $0.0001 par value; 150,000,000 Class A shares authorized; 37,976,764 and 33,206,909 Class A shares issued and outstanding as of December 31, 2025 and 2024, respectively; 1,500,000 Class B shares authorized; 967,759 Class B shares issued and outstanding as of December 31, 2025 and 2024. | 4,000 | 3,000 | 3,000 | 3,000 | 3,000 | |
| Additional paid-in capital | 387 | 328 | 317 | 311 | 305 | |
| Accumulated other comprehensive income | 262,000 | 60,000 | −15,000 | −981,000 | −183,000 | |
| Accumulated deficit | −312 | −280 | −247 | −211 | −166 | |
| Total stockholders' equity | 75 | 48 | 70 | 99 | 139 | |
| Total liabilities and stockholders' equity | 102 | 73 | 95 | 116 | 147 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation and amortization | 940,000 | 833,000 | 900,000 | 800,000 | 700,000 | |
| Stock-based compensation | 5 | 7 | 5 | 5 | 3 | |
| Non-cash lease expense | 492,000 | 567,000 | 526,000 | 462,000 | 0 | |
| Non-cash investment income, net | 314,000 | −910,000 | −1 | −239,000 | — | |
| Other | −5,000 | −69,000 | 18,000 | −22,000 | 90,000 | |
| Accounts receivable | 22,000 | 126,000 | −47,000 | −86,000 | −25,000 | |
| Other receivables | 19,000 | 11 | −5 | −3 | −3 | |
| Prepaid expenses and other assets | −352,000 | −10,000 | 465,000 | 718,000 | −2 | |
| Accounts payable | −1 | 455,000 | −442,000 | 352,000 | 603,000 | |
| Accrued and other current liabilities | 682,000 | −575,000 | −2 | −514,000 | 1 | |
| Deferred revenue | 92,000 | −12,000 | 11 | 6 | 3 | |
| Net cash used in operating activities | −26 | −14 | −27 | −35 | −32 | |
| Purchases of marketable securities | −88 | −36 | −54 | −48 | −82 | |
| Proceeds from maturities and sales of marketable securities | 60 | 49 | 54 | 54 | 800,000 | |
| Purchases of property and equipment | −726,000 | −56,000 | −128,000 | −791,000 | −1 | |
| Purchase of intangible assets | 0 | −1 | 0 | — | — | |
| Net cash (used in) provided by investing activities | −29 | 12 | 438,000 | 6 | −83 | |
| Proceeds from public offering of common stock, net of issuance costs | 54 | — | — | — | — | |
| Proceeds from exercise of stock options | 507,000 | 3 | 1 | 308,000 | 592,000 | |
| Proceeds from employee stock purchase plan | 103,000 | 147,000 | 123,000 | 0 | — | |
| Finance lease principal payments | −194,000 | −440,000 | −466,000 | −303,000 | −70,000 | |
| Net cash provided by financing activities | 54 | 3 | 752,000 | 5,000 | 160 | |
| Net (decrease) increase in cash and cash equivalents | −99,000 | 163,000 | −26 | −29 | 45 | |
| Cash paid for interest | 9,000 | 28,000 | 55,000 | 48,000 | 1 | |
| Issuance of stock to settle accrued and other current liabilities | 0 | 406,000 | 0 | — | — | |
| Purchases of property and equipment in accounts payable and accrued and other current liabilities | 9,000 | 0 | 20,000 | 0 | 154,000 |