Trevi Therapeutics, Inc.
Business
Trevi Therapeutics is a clinical-stage biopharmaceutical company developing Haduvio (oral nalbuphine ER), an investigational mixed kappa-opioid receptor agonist and mu-opioid receptor antagonist for chronic cough. The company is pursuing three clinical programs: IPF-related chronic cough, non-IPF interstitial lung disease-related chronic cough, and refractory chronic cough, with Phase 2 data supporting advancement to Phase 3 trials. Trevi retains worldwide commercial rights with a specialty sales force targeting pulmonologists and related specialists in the U.S. and third-party partnerships for international markets.
Summary from 10-K filed 2026-03-17
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 33 | 39 | 24 | 20 | 23 | |
| General and administrative | 16 | 12 | 10 | 10 | 9 | |
| Total operating expenses | 49 | 52 | 34 | 30 | 32 | |
| Loss from operations | −49 | −52 | −34 | −30 | −32 | |
| Interest income, net | 7 | 4 | 5 | — | — | |
| Other expense, net | −31,000 | −15,000 | 469,000 | 289,000 | −375,000 | |
| Interest expense | 0 | −4,000 | −391,000 | — | — | |
| Total other income, net | 7 | 4 | 5 | 719,000 | −1 | |
| Loss before income taxes | −43 | −48 | −29 | −29 | −34 | |
| Income tax benefit | −64,000 | −30,000 | 32,000 | 36,000 | 21,000 | |
| Net loss | −43 | −48 | −29 | −29 | −34 | |
| Basic net loss per common share outstanding | −0.32 | −0.47 | −0.29 | −0.45 | −1.49 | |
| Diluted net loss per common share outstanding | −0.32 | −0.47 | −0.29 | −0.45 | −1.49 | |
| Weighted average common shares used in net loss per share attributable to common stockholders, basic | 135 | 102 | 99 | 65 | 23 | |
| Weighted average common shares used in net loss per share attributable to common stockholders, diluted | 135 | 102 | 99 | 65 | 23 | |
| Net unrealized gains on available-for-sale marketable securities | 87,000 | 90,000 | 93,000 | −122,000 | — | |
| Comprehensive loss | −43 | −48 | −29 | −29 | −34 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 19 | 34 | 32 | 13 | 37 | |
| Marketable securities | 169 | 74 | 51 | 108 | — | |
| Prepaid expenses | 1 | 939,000 | 4 | 795,000 | 886,000 | |
| Other current assets | 2 | 867,000 | 955,000 | 1 | 241,000 | |
| Total current assets | 192 | 109 | 88 | 123 | 38 | |
| Operating lease right-of-use assets | 677,000 | 915,000 | 1 | 24,000 | 131,000 | |
| Property, equipment and leasehold improvements, net | 178,000 | 157,000 | 216,000 | 170,000 | 53,000 | |
| Other non-current assets | 928,000 | 243,000 | 297,000 | 205,000 | 334,000 | |
| Finance lease right-of-use assets | 0 | 157,000 | 206,000 | — | — | |
| Total assets | 193 | 111 | 89 | 123 | 38 | |
| Accounts payable | 4 | 3 | 2 | 3 | 3 | |
| Accrued expenses | 6 | 7 | 4 | 4 | 4 | |
| Operating lease liabilities | 307,000 | 254,000 | 184,000 | 25,000 | 120,000 | |
| Finance lease liabilities | 0 | 31,000 | 122,000 | — | — | |
| Total current liabilities | 10 | 11 | 6 | 13 | 13 | |
| Operating lease liabilities | 446,000 | 747,000 | 1 | 2,000 | 24,000 | |
| Total liabilities | 10 | 11 | 7 | 16 | 21 | |
| Commitments and contingencies (Note 13) | — | — | — | — | — | |
| Preferred stock: $0.001 par value; 5,000,000 shares authorized at December 31, 2025 and December 31, 2024; no shares issued or outstanding at December 31, 2025 and December 31, 2024.Preferred stock: $0.001 par value; 5,000,000 shares authorized at December 31, 2025 and December 31, 2024; no shares issued or outstanding at December 31, 2025 and December 31, 2024. | — | — | — | — | — | |
| Common stock: $0.001 par value; 200,000,000 shares authorized at December 31, 2025 and December 31, 2024; and 128,306,056 and 93,602,631 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively. | 128,000 | 94,000 | 68,000 | 60,000 | 29,000 | |
| Additional paid-in capital | 513 | 387 | 322 | 318 | 198 | |
| Accumulated other comprehensive income | 148,000 | 61,000 | −29,000 | −122,000 | — | |
| Accumulated deficit | −330 | −287 | −239 | −210 | −181 | |
| Total stockholders equity | 183 | 100 | 83 | 107 | 17 | |
| Total liabilities and stockholders equity | 193 | 111 | 89 | 123 | 38 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Stock-based compensation | 5 | 4 | 2 | 2 | 3 | |
| Operating lease right-of-use assets | 437,000 | 460,000 | 377,000 | 0 | — | |
| Depreciation and amortization | 144,000 | 147,000 | 123,000 | 43,000 | — | |
| Accretion of available-for-sale marketable securities, net | −2 | −1 | −2 | −829,000 | — | |
| Write off of deferred offering costs | 26,000 | — | 390,000 | — | — | |
| Loss on disposal of property, equipment and leasehold improvements | 7,000 | — | 10,000 | — | — | |
| Prepaid expenses and other current assets | −1 | 3 | −3 | −601,000 | 342,000 | |
| Accrued expenses and other liabilities | −1 | 3 | 52,000 | −639,000 | 336,000 | |
| Accounts payable | −598,000 | 2 | −1 | 9,000 | 831,000 | |
| Net cash used in operating activities | −42 | −38 | −32 | −28 | −29 | |
| Proceeds from maturities of available-for-sale marketable securities | 77 | 77 | 69 | 19 | — | |
| Purchases of available-for-sale marketable securities | −171 | −98 | −10 | −126 | — | |
| Purchases of property, equipment and leasehold improvements | −12,000 | −35,000 | −137,000 | −159,000 | — | |
| Net cash used in investing activities | −94 | −22 | 59 | −107 | — | |
| Proceeds from offering, net of commissions | 108 | 47 | — | — | — | |
| Proceeds from exercises of warrants | 11 | — | — | 12 | 3,000 | |
| Proceeds from exercises of stock options | 2 | 394,000 | 74,000 | 139,000 | — | |
| Proceeds from disgorgement of beneficial owner's short-swing profits | 725,000 | — | — | — | — | |
| Proceeds from employee stock purchase plan | 118,000 | 70,000 | 68,000 | 56,000 | 39,000 | |
| Payments of offering costs | −809,000 | — | −258,000 | −226,000 | −382,000 | |
| Payments of finance lease | −11,000 | −126,000 | −95,000 | — | — | |
| Proceeds from at-the-market sales, net of commissions | — | 14 | 2 | — | 8 | |
| Net cash provided by financing activities | 121 | 61 | −8 | 111 | 21 | |
| Net (decrease) increase in cash and cash equivalents | −15 | 2 | 20 | −24 | −8 | |
| Interest paid | — | −4,000 | −331,000 | −594,000 | 603,000 | |
| State research tax credits exchanged for cash | 33,000 | 32,000 | 55,000 | — | 18,000 | |
| Offering costs included in accrued expenses | — | 233,000 | — | 15,000 | 41,000 |
Filings
Material Events
Insiders
Institutional Holders
Frequently asked questions
What is Trevi Therapeutics, Inc.'s CIK number?
Trevi Therapeutics, Inc.'s SEC CIK number is 0001563880 (1563880). The CIK (Central Index Key) is the permanent identifier the SEC assigns to every EDGAR filer — unlike a ticker symbol, it never changes.
Where can I find Trevi Therapeutics, Inc.'s SEC filings?
All of Trevi Therapeutics, Inc.'s EDGAR filings — 10-K annual reports, 10-Q quarterly reports, 8-K material events, and insider transactions — are listed on this page, sourced live from SEC EDGAR.
When did Trevi Therapeutics, Inc. last report earnings?
Trevi Therapeutics, Inc. (TRVI) most recently filed an earnings 8-K with the SEC on May 5, 2026, furnishing its results under Item 2.02 (Results of Operations and Financial Condition). The earnings press release is attached to that filing (accession 0001193125-26-206382). This is Trevi Therapeutics, Inc.'s most recent earnings filing of record — not a forecast of its next earnings date.
What is Trevi Therapeutics, Inc.'s most recent earnings 8-K?
Trevi Therapeutics, Inc.'s latest earnings 8-K (Item 2.02) was filed May 5, 2026 under accession 0001193125-26-206382. It carries the quarterly or annual earnings press release — the earliest official, SEC-filed version of the results.
View Trevi Therapeutics, Inc.'s latest earnings 8-K →
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