Unicycive Therapeutics, Inc.
Business
Unicycive Therapeutics, Inc. is a clinical-stage biotechnology company focused on identifying, developing, and commercializing innovative therapies to address unmet medical needs with an initial emphasis on kidney disease. It develops two lead product candidates: Oxylanthanum Carbonate, an oral nanoparticle-based phosphate binder for hyperphosphatemia in dialysis patients, and UNI-494, a prodrug of nicorandil for acute kidney injury and delayed graft function. Its business model centers on in‑licensing assets, clinical development, regulatory filings, and selective commercialization or partnering. The company targets U.S. approval and commercialization while pursuing licensing and distribution partnerships in international markets and relies on contract manufacturers and regional licensees for supply and market access.
Summary from filing dated 2025-03-31
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 9 | 20 | 13 | 12 | 6 | |
| General and administrative | 20 | 12 | 9 | 7 | 3 | |
| Total operating expenses | 30 | 32 | 21 | 19 | 9 | |
| Loss from operations | −30 | −32 | −21 | −18 | −9 | |
| Interest income | 1 | 1 | 615,000 | — | — | |
| Interest expense | −71,000 | −71,000 | −82,000 | — | — | |
| Change in fair value of warrant liability | 2 | −6 | −10 | — | — | |
| Total other income (expenses) | 3 | −5 | −10 | −6,000 | −1 | |
| Net loss | −27 | −37 | −31 | −18 | −10 | |
| Unrealized loss on marketable securities, net | −1,000 | — | — | — | — | |
| Net comprehensive loss | −27 | −37 | — | — | — | |
| Dividend to Series B-1 preferred stockholders | — | −1 | −867,000 | — | — | |
| Net loss attributable to common stockholders | −27 | −38 | −31 | −18 | — | |
| Net loss per share attributable to common stockholders, basic (in Dollars per share) | −1.67 | −5.65 | −1.28 | −1.2 | −0.86 | |
| Net loss per share attributable to common stockholders, diluted (in Dollars per share) | −1.67 | −5.65 | −1.28 | −1.2 | −0.86 | |
| Weighted-average shares outstanding used in computing net loss per share, basic (in Shares) | 16 | 7 | 25 | 15 | 12 | |
| Weighted-average shares outstanding used in computing net loss per share, diluted (in Shares) | 16 | 7 | 25 | 15 | 12 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 29 | 26 | — | 455,000 | 17 | |
| Prepaid expenses and other current assets | 8 | 5 | 4 | 2 | 2 | |
| Marketable securities | 12 | — | — | — | — | |
| Total current assets | 49 | 31 | 13 | 3 | 18 | |
| Right of use asset, net | 108,000 | 645,000 | 766,000 | 152,000 | 305,000 | |
| Property and equipment, net | 66,000 | 75,000 | 26,000 | 22,000 | 28,000 | |
| Total assets | 49 | 32 | 14 | 3 | 19 | |
| Accounts payable | 383,000 | 1 | 839,000 | 892,000 | 742,000 | |
| Accrued liabilities | 2 | 4 | 3 | 2 | 1 | |
| Warrant liability | 17 | 19 | 13 | — | — | |
| Operating lease liability - current | 117,000 | 564,000 | 327,000 | 155,000 | 151,000 | |
| Total current liabilities | 19 | 24 | 18 | 3 | 2 | |
| Operating lease liability long term | — | 117,000 | 466,000 | — | 155,000 | |
| Total liabilities | 19 | 24 | 18 | 3 | 2 | |
| Commitments and contingencies (Note 7) | — | — | — | — | — | |
| Preferred stock, value | — | — | — | — | — | |
| Common stock, $0.001 par value per share 400,000,000 shares authorized at December 31, 2024, and December 31, 2025; 11,384,236 and 22,114,245 shares issued and outstanding at December 31, 2024, and December 31, 2025, respectively | 22,000 | 11,000 | 35,000 | 15,000 | 15,000 | |
| Accumulated other comprehensive loss | −1,000 | — | — | — | — | |
| Additional paid-in capital | 158 | 109 | 61 | 34 | 32 | |
| Accumulated deficit | −128 | −101 | −65 | −34 | −16 | |
| Total stockholders equity | 30 | 7 | −4 | −466,000 | 16 | |
| Total liabilities and stockholders equity | 49 | 32 | 14 | 3 | 19 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation expense | 34,000 | 22,000 | 9,000 | 7,000 | 1,000 | |
| Stock-based compensation expense | 3 | 2 | 2 | 1 | — | |
| Amortization of operating lease right of use asset | 500,000 | 406,000 | 275,000 | 154,000 | 12,000 | |
| Prepaid expense and other current assets | −3 | −820,000 | −1 | 62,000 | — | |
| Accounts payable and accrued liabilities | −3 | 790,000 | 1 | 1 | 1 | |
| Operating lease liability | −565,000 | −397,000 | −252,000 | −151,000 | −12,000 | |
| Net cash used in operating activities | −31 | −29 | −18 | −16 | −6 | |
| Purchases of marketable securities | −12 | — | — | — | — | |
| Purchases of property and equipment | −24,000 | −72,000 | −12,000 | −2,000 | −29,000 | |
| Net cash used in investing activities | −12 | −72,000 | −12,000 | −2,000 | −29,000 | |
| Gross proceeds from secondary public offering | 47 | 683,000 | — | — | — | |
| Commissions paid on secondary public offering | −1 | — | — | — | — | |
| Deferred cost of at the market offering | — | −160,000 | — | — | — | |
| Payments on financed insurance policies | −212,000 | −527,000 | −496,000 | — | — | |
| Issuance costs related to issuance of Series B-1 preferred stock | — | −4 | — | — | — | |
| Proceeds from issuance of Series B-1 preferred stock | — | 50 | — | — | — | |
| Proceeds from exercise of warrants | 1 | — | — | — | — | |
| Dividends on preferred stock | — | −1 | — | — | — | |
| Net cash provided by financing activities | 46 | 45 | 28 | −471,000 | 22 | |
| Net increase in cash and cash equivalents | 3 | 16 | 9 | −16 | — | |
| Issuance of Series B-2 preferred stock and common stock upon conversion of Series B-1 preferred stock | — | 46 | — | — | — | |
| Deferred insurance charges included in prepaid expenses and other current assets | 332,000 | 267,000 | 270,000 | 240,000 | — | |
| Cash paid for interest | — | 12,000 | 24,000 | 6,000 | — |