Celldex Therapeutics, Inc.
Business
Celldex Therapeutics, Inc. is a biopharmaceutical company that researches and develops therapeutic antibodies focused on mast cell biology to treat severe inflammatory, allergic and autoimmune diseases. Its main product candidates include monoclonal antibody barzolvolimab (anti‑KIT) and a next‑generation bispecific platform exemplified by CDX‑622 (anti‑TSLP/anti‑SCF), along with related preclinical and formulation activities. Key business functions comprise discovery and clinical development, manufacturing (internal cGMP capacity and external CDMOs) and business development/partnerships. The company conducts global clinical trials and distributes investigational drug product through clinical sites and contract manufacturers, with formulations designed for clinic and potential at‑home subcutaneous administration.
Summary from filing dated 2025-02-27
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenues | 2 | 7 | 7 | 2 | 5 | |
| Research and development | 245 | 164 | 118 | 82 | 53 | |
| General and administrative | 44 | 39 | 31 | 27 | 20 | |
| Litigation settlement related loss | — | — | 13 | 15 | — | |
| Total operating expenses | 289 | 202 | 161 | 118 | 76 | |
| Operating loss | −287 | −195 | −155 | −115 | −71 | |
| Investment and other income, net | 29 | 37 | 13 | 3 | 505,000 | |
| Net loss | −259 | −158 | −141 | — | — | |
| Basic net loss per common share (in dollars per share) | −3.9 | −2.45 | −2.92 | −2.4 | −1.64 | |
| Diluted net loss per common share (in dollars per share) | −3.9 | −2.45 | −2.92 | −2.4 | −1.64 | |
| Shares used in calculating basic net loss per share (in shares) | 66 | 64 | 48 | 46,888 | 42,870 | |
| Shares used in calculating diluted net loss per share (in shares) | 66 | 64 | 48 | 46,888 | 42,870 | |
| Unrealized gain on marketable securities | 312,000 | 6,000 | 2 | −634,000 | −695,000 | |
| Comprehensive loss | −258 | −158 | −139 | −113 | −71 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 29 | 28 | 35 | 29 | 39 | |
| Marketable securities | 490 | 697 | 389 | 276 | 369 | |
| Accounts and other receivables | 2 | 700,000 | 3 | 347,000 | 172,000 | |
| Prepaid and other current assets | 14 | 21 | 5 | 12 | 2 | |
| Total current assets | 535 | 747 | 432 | 318 | 411 | |
| Property and equipment, net | 5 | 4 | 4 | 4 | 4 | |
| Operating lease right-of-use assets, net | 2 | 4 | 3 | 4 | 3 | |
| Intangible assets | 27 | 27 | 27 | 27 | 27 | |
| Other assets | 13 | 10 | 107,000 | 104,000 | 104,000 | |
| Total assets | 583 | 792 | 466 | 353 | 445 | |
| Accounts payable | 1 | 3 | 3 | 3 | 1 | |
| Accrued expenses | 47 | 34 | 22 | 13 | 12 | |
| Current portion of operating lease liabilities | 2 | 1 | 2 | 1 | 2 | |
| Current portion of long-term liabilities | 1 | 942,000 | 4 | 990,000 | 2 | |
| Total current liabilities | 51 | 40 | 31 | 19 | 17 | |
| Long-term portion of operating lease liabilities | 784,000 | 2 | 928,000 | 3 | 1 | |
| Other long-term liabilities | 4 | 3 | 4 | 5 | 7 | |
| Total liabilities | 56 | 45 | 36 | 27 | 25 | |
| Commitments and contingent liabilities (Note 15) | — | — | — | — | — | |
| Convertible preferred stock, $.01 par value; 3,000,000 shares authorized; no shares issued and outstanding at December 31, 2025 and 2024 | — | — | — | — | — | |
| Common stock, $.001 par value; 297,000,000 shares authorized; 66,549,442 and 66,374,549 shares issued and outstanding at December 31, 2025 and 2024, respectively | 67,000 | 66,000 | 56,000 | 47,000 | 47,000 | |
| Additional paid-in capital | 2,337 | 2,299 | 1,823 | 1,581 | 1,561 | |
| Accumulated other comprehensive income | 4 | 3 | 3 | 1 | 2 | |
| Accumulated deficit | −1,814 | −1,555 | −1,397 | −1,256 | −1,144 | |
| Total stockholders' equity | 527 | 747 | 429 | 326 | 419 | |
| Total liabilities and stockholders' equity | 583 | 792 | 466 | 353 | 445 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −259 | −158 | −141 | — | — | |
| Depreciation and amortization | 3 | 3 | 3 | 3 | 3 | |
| Amortization and premium of marketable securities, net | −6 | −16 | −6 | 844,000 | −3 | |
| Loss on disposal of assets | 12,000 | 16,000 | — | 2,000 | −24,000 | |
| Stock-based compensation expense | 36 | 34 | 24 | 16 | 9 | |
| Accounts and other receivables | −1 | 2 | −2 | −175,000 | 2 | |
| Prepaid and other current assets | 9 | −20 | 6 | −10 | −2 | |
| Other assets | −4 | −10 | −3,000 | — | −5,000 | |
| Accounts payable and accrued expenses | 11 | 12 | 9 | 3 | 4 | |
| Other liabilities | −753,000 | −6 | 462,000 | 3 | −4 | |
| Net cash used in operating activities | −211 | −158 | −107 | −104 | −61 | |
| Sales and maturities of marketable securities | 596 | 502 | 321 | 281 | 175 | |
| Purchases of marketable securities | −385 | −790 | −425 | −189 | −390 | |
| Acquisition of property and equipment | −3 | −2 | −2 | −2 | −1 | |
| Net cash provided by (used in) investing activities | 209 | −290 | −106 | 90 | −216 | |
| Net proceeds from stock issuances | — | 432 | 216 | — | 270 | |
| Proceeds from issuance of stock from employee benefit plans | 2 | 9 | 2 | 4 | 2 | |
| Net cash provided by financing activities | 2 | 441 | 218 | 4 | 272 | |
| Net increase (decrease) in cash and cash equivalents | 515,000 | −6 | 5 | −10 | −5 | |
| Accrued construction in progress | 98,000 | 27,000 | 77,000 | 113,000 | 289,000 |