HERON THERAPEUTICS, INC. /DE/
Business
HERON THERAPEUTICS, INC. is a commercial-stage biotechnology company that develops and commercializes therapeutic innovations to improve acute care and oncology patient outcomes. Its main products include acute care offerings ZYNRELEF (an extended-release bupivacaine/meloxicam local anesthetic) and APONVIE (an IV NK1 antagonist for PONV), and oncology products CINVANTI (IV aprepitant) and SUSTOL (extended-release granisetron), supported by its proprietary Biochronomer drug-delivery technology. Heron organizes its business into acute care and oncology product portfolios and conducts sales, marketing and commercialization activities through a targeted U.S. acute care and oncology sales force, co-promotion partnerships and third-party manufacturing agreements. Products are marketed and distributed primarily in the United States through specialty distributors and full-line wholesalers to hospitals, healthcare providers and government and payor accounts.
Summary from filing dated 2025-02-27
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net product sales | 155 | 144 | 127 | 108 | 86 | |
| Cost of product sales | 41 | 39 | 65 | 55 | 46 | |
| Gross profit | 114 | 106 | 62 | 53 | — | |
| Research and development | 12 | 17 | 39 | 83 | 131 | |
| General and administrative | 55 | 53 | 66 | 62 | 40 | |
| Sales and marketing | 49 | 47 | 68 | 83 | 87 | |
| Total operating expenses | 116 | 117 | 173 | 227 | 304 | |
| Loss from operations | −3 | −12 | −111 | −175 | −218 | |
| Interest income | 2 | 4 | 3 | 2 | 433,000 | |
| Interest expense | −10 | −6 | −4 | −2 | — | |
| Loss on debt extinguishment | −11 | — | — | — | — | |
| Other income | 1 | 430,000 | 560,000 | −7 | −878,000 | |
| Total other (expense) income, net | −18 | −2 | 56,000 | −7 | −3 | |
| Net loss | −20 | −14 | −111 | −182 | −221 | |
| Unrealized (losses) gains on short-term investments | −9,000 | — | 32,000 | −13,000 | −263,000 | |
| Comprehensive loss | −20 | −14 | −111 | −182 | −221 | |
| Basic net loss per share | −0.12 | −0.09 | −0.8 | −1.67 | −2.24 | |
| Shares used in computing basic net loss per share | 167 | 152 | 138 | 109 | 98,471 | |
| Diluted net loss per share | −0.12 | −0.09 | −0.8 | −1.67 | −2.24 | |
| Shares used in computing diluted net loss per share | 167 | 152 | 138 | 109 | 98,471 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 29 | 26 | 29 | 15 | 91 | |
| Short-term investments | 18 | 33 | 52 | 69 | 67 | |
| Accounts receivable, net | 90 | 79 | 60 | 52 | 35 | |
| Inventory, net | 93 | 53 | 42 | 55 | 48 | |
| Prepaid expenses and other current assets | 9 | 18 | 6 | 14 | 13 | |
| Total current assets | 238 | 209 | 189 | 205 | 254 | |
| Property and equipment, net | 12 | 15 | 20 | 22 | 24 | |
| Right-of-use lease assets | 0 | 3 | 5 | 8 | 10 | |
| Other assets | 5 | 6 | 8 | 16 | 18 | |
| Total assets | 256 | 233 | 223 | 251 | 306 | |
| Accounts payable | 9 | 12 | 3 | 3 | 4 | |
| Accrued clinical and manufacturing liabilities | 27 | 25 | 22 | 24 | 24 | |
| Accrued payroll and employee liabilities | 9 | 10 | 9 | 13 | 15 | |
| Other accrued liabilities | 51 | 42 | 42 | 39 | 26 | |
| Current lease liabilities | 0 | 3 | 3 | 3 | 2 | |
| Total current liabilities | 96 | 91 | 80 | 82 | 71 | |
| Non-current notes payable, net | 108 | 25 | 24 | — | — | |
| Non-current convertible notes payable, net | 33 | 150 | 149 | 149 | 149 | |
| Other non-current liabilities | 5 | 615,000 | 241,000 | 241,000 | — | |
| Total liabilities | 242 | 267 | 256 | 237 | 228 | |
| Commitments and contingencies (see Note 6) | — | — | — | — | — | |
| Common stock, $0.01 par value: 400,000,000 shares authorized; 188,314,430 shares issued and outstanding at December 31, 2025 and 152,127,878 shares issued and outstanding at December 31, 2024 | 2 | 2 | 2 | 1 | 1 | |
| Series A convertible preferred stock, $0.01 par value: 2,500,000 shares authorized; 70,012 shares issued and outstanding at December 31, 2025 and no shares issued and outstanding at December 31, 2024 | 1 | 0 | — | — | — | |
| Additional paid-in capital | 1,951 | 1,884 | 1,871 | 1,808 | 1,690 | |
| Accumulated other comprehensive income | 4,000 | 13,000 | 13,000 | −19,000 | −6,000 | |
| Accumulated deficit | −1,940 | −1,920 | −1,906 | −1,795 | −1,613 | |
| Total stockholders' equity (deficit) | 14 | −34 | −34 | 14 | 78 | |
| Total liabilities and stockholders' equity (deficit) | 256 | 233 | 223 | 251 | 306 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −20 | −14 | −111 | — | — | |
| Stock-based compensation expense | 10 | 13 | 33 | 43 | 47 | |
| Depreciation and amortization | 2 | 3 | 3 | 3 | 3 | |
| Amortization of debt discount | 744,000 | 751,000 | 133,000 | — | 785,000 | |
| Amortization of debt issuance costs | 73,000 | 210,000 | 206,000 | 202,000 | 119,000 | |
| Accretion of discount on short-term investments | −739,000 | −2 | −2 | −736,000 | 332,000 | |
| Retirement and impairment of property and equipment | 414,000 | 4 | 617,000 | 209,000 | — | |
| (Gain)/Loss on disposal of property and equipment | — | −27,000 | 10,000 | 74,000 | 822,000 | |
| Accounts receivable | −11 | −19 | −8 | −17 | 6 | |
| Inventory | −31 | −11 | 12 | −6 | −6 | |
| Prepaid expenses and other assets | 878,000 | −10 | 15 | 1 | −8 | |
| Accounts payable | −3 | 8 | 15,000 | −578,000 | 3 | |
| Accrued clinical and manufacturing liabilities | 1 | 3 | −2 | 752,000 | −26 | |
| Accrued payroll and employee liabilities | −284,000 | 330,000 | −4 | −2 | 2 | |
| Other accrued liabilities | 11 | 99,000 | 3 | 13 | −5 | |
| Net cash used in operating activities | −28 | −23 | −59 | −147 | −203 | |
| Purchases of short-term investments | −51 | −103 | −88 | −146 | −129 | |
| Maturities and sales of short-term investments | 67 | 123 | 107 | 144 | 165 | |
| Purchases of property and equipment | −317,000 | −2 | −2 | −2 | −3 | |
| Proceeds from the sale of property and equipment | 98,000 | 27,000 | 13,000 | 227,000 | 32,000 | |
| Net cash provided by investing activities | 16 | 19 | 18 | −3 | 33 | |
| Net proceeds from the sale of common stock | 18 | — | 30 | 75 | — | |
| Proceeds from sale of Series A Convertible Preferred Stock | 8 | — | — | — | — | |
| Cash paid for convertible notes extinguishment | −125 | — | — | — | — | |
| Cash paid for notes extinguishment | −25 | — | — | — | — | |
| Net proceeds from convertible note issuance | 32 | — | — | — | 149 | |
| Net proceeds from notes issuance | 105 | — | 24 | — | — | |
| Proceeds from warrant exercises | — | — | 1,000 | — | — | |
| Proceeds from purchases under the Employee Stock Purchase Plan | 853,000 | 637,000 | 904,000 | 1 | 2 | |
| Receipts (payments) for stock issued under the equity incentive plan | 160,000 | 303,000 | −903,000 | −2 | 5 | |
| Net cash provided by financing activities | 14 | 940,000 | 54 | 75 | 156 | |
| Net increase (decrease) in cash and cash equivalents | 3 | −3 | 13 | −75 | −15 | |
| Interest paid | 7 | 5 | 3 | 2 | 1 |