Immunome Inc.
Business
Immunome Inc. is a clinical-stage targeted oncology company developing targeted therapies designed to improve outcomes for cancer patients. It develops therapeutics including antibody-drug conjugates (ADCs), a gamma secretase inhibitor (varegacestat), fibroblast activation protein-targeted radioligand therapy (IM-3050), proprietary TOP1 inhibitor payloads (HC74), linkers and related discovery assets across preclinical and clinical programs. Key business segments include ADC discovery and optimization, clinical development programs, radioligand therapy development, and intellectual property/licensing and manufacturing partnerships. Immunome conducts global clinical trials and relies on third-party manufacturers and regulatory channels across North America, Europe, Asia and Australia.
Summary from filing dated 2025-03-19
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Collaboration revenue | 7 | 9 | 14 | — | — | |
| In-process research and development | 10 | 152 | 81 | — | — | |
| Research and development | 177 | 130 | 23 | 23 | 14 | |
| General and administrative | 44 | 33 | 20 | 14 | 11 | |
| Total operating expenses | 231 | 315 | 124 | 37 | 25 | |
| Loss from operations | −224 | −306 | −110 | −37 | −25 | |
| Interest income | 12 | 13 | 3 | 5,000 | −10,000 | |
| Net loss | −212 | −293 | −107 | −37 | −25 | |
| Net loss per share, basic | −2.43 | −5 | −5.38 | −3.09 | −2.14 | |
| Net loss per share, diluted | −2.43 | −5 | −5.38 | −3.09 | −2.14 | |
| Weighted-average shares outstanding, basic | 87 | 59 | 20 | 12 | 12 | |
| Weighted-average shares outstanding, diluted | 87 | 59 | 20 | 12 | 12 | |
| Net loss | −212 | −293 | −107 | −38 | −25 | |
| Unrealized (loss) gain on marketable securities | −57,000 | 35,000 | — | — | — | |
| Comprehensive loss | −212 | −293 | −107 | −38 | — |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 654 | 143 | 99 | 20 | 49 | |
| Marketable securities | 0 | 74 | 39 | — | — | |
| Prepaid expenses and other current assets | 7 | 4 | 7 | 2 | 7 | |
| Total current assets | 661 | 221 | 145 | 23 | 57 | |
| Property and equipment, net | 15 | 10 | 2 | 681,000 | 855,000 | |
| Operating right-of-use assets | 3 | 4 | 2 | 284,000 | 500,000 | |
| Restricted cash | 200,000 | 100,000 | 100,000 | 100,000 | 100,000 | |
| Other long-term assets | 5 | 4 | 100,000 | — | — | |
| Total assets | 683 | 240 | 149 | 24 | 58 | |
| Accounts payable | 3 | 14 | 3 | 2 | 3 | |
| Accrued expenses and other current liabilities | 42 | 33 | 8 | 5 | 7 | |
| Deferred revenue, current | 0 | 7 | 10 | — | — | |
| Total current liabilities | 45 | 54 | 22 | 7 | 10 | |
| Operating lease liabilities, net of current portion | 4 | 5 | 1 | — | — | |
| Total liabilities | 49 | 59 | 29 | 7 | 10 | |
| Preferred stock, $0.0001 par value; 10,000,000 shares authorized; no shares issued or outstanding at December 31, 2025 and 2024 | — | — | — | — | — | |
| Common stock, $0.0001 par value; 300,000,000 shares authorized at December 31, 2025 and 2024; 113,133,199 and 64,460,829 shares issued and outstanding at December 31, 2025 and 2024, respectively | 11,000 | 6,000 | 4,000 | 1,000 | 1,000 | |
| Additional paid-in capital | 1,362 | 697 | 343 | 133 | 127 | |
| Accumulated other comprehensive income | 0 | 57,000 | 22,000 | — | — | |
| Accumulated deficit | −728 | −516 | −223 | −116 | −79 | |
| Total stockholders' equity | 634 | 181 | 120 | 17 | 48 | |
| Total liabilities and stockholders' equity | 683 | 240 | 149 | 24 | 58 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −212 | −293 | −107 | −37 | −25 | |
| Depreciation and amortization | 3 | 2 | 500,000 | 400,000 | 800,000 | |
| Amortization of right-of-use asset | 489,000 | 535,000 | 271,000 | 209,000 | — | |
| Accretion of discounts on marketable securities | −3 | −3 | −512,000 | — | — | |
| Share-based compensation expense | 26 | 16 | 6 | 5 | 3 | |
| Loss on disposal of property and equipment | 896,000 | 0 | — | — | — | |
| Charge for purchase of in-process research and development assets, including upon achievement of milestones | 10 | 152 | — | — | — | |
| Prepaid expenses and other assets | −3 | 906,000 | −4 | 5 | −4 | |
| Accounts payable | −9 | 10 | −608,000 | −677,000 | 2 | |
| Accrued expenses and other current liabilities | 5 | 14 | 614,000 | −2 | 5 | |
| Deferred revenue | −7 | −9 | 16 | — | — | |
| Operating lease liabilities | −166,000 | −67,000 | 153,000 | — | — | |
| Net cash used in operating activities | −191 | −111 | −8 | −29 | −18 | |
| Maturities of marketable securities | 200 | 155 | — | — | — | |
| Purchases of marketable securities | −123 | −187 | −39 | — | — | |
| Purchases of property and equipment | −10 | −7 | −831,000 | −248,000 | −79,000 | |
| Purchases of in-process research and development assets | −6 | −46 | — | — | — | |
| Net cash provided by (used in) investing activities | 61 | −85 | −30 | −248,000 | −79,000 | |
| Proceeds from public offerings | 633 | 230 | — | — | — | |
| Proceeds from issuance of common stock under ATM | 46 | 20 | 34,000 | — | 1 | |
| Payment of offering costs | −39 | −15 | −9 | — | −222,000 | |
| Proceeds from exercise of stock options | 913,000 | 2 | 371,000 | 32,000 | 99,000 | |
| Proceeds from exercise of common stock warrants | 0 | 4 | — | — | — | |
| Net cash provided by financing activities | 640 | 241 | 116 | 32,000 | 28 | |
| Net increase in cash and cash equivalents and restricted cash | 510 | 45 | 78 | −29 | 9 | |
| Purchases of in-process research and development assets, including payments owed upon achievement of development milestones, in accounts payable and accrued expenses | 10 | 6 | — | — | — | |
| Purchases of property and equipment in accounts payable and accrued expenses and other current liabilities | 1 | 3 | 372,000 | — | — | |
| Remeasurement of operating right-of-use asset and lease liability due to lease modifications | 811,000 | 2 | 226,000 | — | — | |
| Offering costs in accounts payable and accrued expenses and other current liabilities | 364,000 | 0 | — | — | — | |
| Issuance of common stock in exchange for in-process research and development assets | — | 98 | — | — | — | |
| Net liabilities assumed from purchases of in-process research and development assets | 0 | 2 | — | — | — | |
| Right-of-use assets obtained in exchange for operating lease liabilities | 0 | 1 | 1 | — | — |