X4 Pharmaceuticals, Inc
Business
X4 Pharmaceuticals, Inc is a biopharmaceutical company developing and commercializing novel small‑molecule therapeutics that target the immune system via CXCR4 antagonism. Its main product is mavorixafor, an oral CXCR4 antagonist marketed as XOLREMDI for WHIM syndrome, with ongoing clinical development in chronic neutropenic disorders and preclinical CXCR4 candidates. The company operates as a single reportable segment focused on clinical development, regulatory filings, commercialization, and partner licensing arrangements. It currently markets in the United States and pursues regulatory approvals and commercialization through partners and distributors across Europe, Greater China, the Middle East, Australia and New Zealand, using specialty pharmacy channels and licensees.
Summary from filing dated 2025-03-26
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenue | 35 | 3 | 0 | 0 | 0 | |
| Cost of revenue | 6 | 797,000 | 0 | 0 | — | |
| Research and development | 73 | 82 | 72 | 61 | 51 | |
| General and administrative | 44 | 62 | 36 | 27 | 25 | |
| Gain on sale of non-financial asset | 0 | −105 | 0 | 0 | 0 | |
| Total operating expense | 122 | 39 | 108 | — | — | |
| Loss from operations | −87 | −36 | −108 | −88 | −85 | |
| Interest income | 5 | 6 | 5 | 219,000 | 10,000 | |
| Interest expense | −9 | −9 | −6 | −4 | — | |
| Change in fair value of warrant liability | 13 | 2 | 7 | 2 | −366,000 | |
| Other (expense) income, net | −753,000 | 332,000 | 554,000 | −4 | 426,000 | |
| Total other income (expense), net | 8 | −739,000 | 6 | −6 | −4 | |
| Loss before provision for income taxes | −79 | −37 | −101 | −94 | −89 | |
| Provision for income taxes | 41,000 | 310,000 | 78,000 | 28,000 | 17,000 | |
| Net loss | −79 | −37 | −101 | −94 | −89 | |
| Net loss per share attributable to common stockholdersbasic | −1.87 | −5.59 | −17.07 | −1.52 | −3.99 | |
| Weighted average shares of common stock outstandingbasic | 42 | 7 | 6 | 64 | 26 | |
| Net loss per share attributable to common stockholdersdiluted | −1.87 | −5.59 | −17.07 | −1.52 | −3.99 | |
| Weighted average shares of common stock outstandingdiluted | 42 | 7 | 6 | 64 | 26 | |
| Change in net unrealized gains on marketable debt securities | 13,000 | −3,000 | 0 | −3 | −14 | |
| Comprehensive loss | −79 | −37 | −101 | — | — |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 217 | 56 | 99 | 122 | 82 | |
| Accounts receivable | 573,000 | 1 | 0 | — | — | |
| Marketable securities | 36 | 46 | 15 | 0 | — | |
| Research and development incentive receivable | 0 | 640,000 | 562,000 | 1 | 747,000 | |
| Inventory | 4 | 3 | — | — | — | |
| Prepaid expenses and other current assets | 4 | 6 | 7 | 6 | 5 | |
| Total current assets | 262 | 112 | 122 | 129 | 88 | |
| Property and equipment, net | 182,000 | 776,000 | 745,000 | 1 | 2 | |
| Goodwill | 17 | 17 | 17 | 17 | 17 | |
| Intangible asset, net | 9 | 10 | 0 | — | — | |
| Right-of-use assets | 1 | 4 | 6 | 7 | 9 | |
| Other assets | 692,000 | 2 | 1 | 1 | 2 | |
| Total assets | 290 | 146 | 147 | 156 | 117 | |
| Accounts payable | 6 | 9 | 9 | 8 | 4 | |
| Accrued expenses | 19 | 23 | 13 | 12 | 8 | |
| Deferred revenue | 464,000 | 0 | — | — | — | |
| Current portion of lease liability | 994,000 | 1 | 1 | 1 | 1 | |
| Total current liabilities | 26 | 33 | 23 | 22 | 14 | |
| Long-term debt, including accretion, net of discount | 76 | 75 | — | — | — | |
| Lease liabilities | 0 | 1 | 3 | 4 | 5 | |
| Warrant liability | 977,000 | 14 | 16 | 23 | 0 | |
| Deferred revenue | 621,000 | 0 | — | — | — | |
| Other liabilities | 525,000 | 831,000 | 432,000 | 173,000 | 826,000 | |
| Total liabilities | 104 | 124 | 96 | 82 | 53 | |
| Commitments and contingencies (Note 13) | — | — | — | — | — | |
| Preferred stock, $0.001 par value. 10,000,000 shares authorized and no shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively | 0 | 0 | 0 | — | — | |
| Common stock, $0.001 par value, 500,000,000 shares authorized as of December 31, 2025 and December 31, 2024; 90,906,920 and 5,698,231 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively | 91,000 | 6,000 | 167,000 | 122,000 | 28,000 | |
| Additional paid-in capital | 781 | 538 | 529 | 451 | 347 | |
| Accumulated other comprehensive loss | −109,000 | −122,000 | −119,000 | −119,000 | −119,000 | |
| Accumulated deficit | −595 | −515 | −478 | −377 | −283 | |
| Total stockholders equity | 186 | 22 | 51 | 74 | 64 | |
| Total liabilities and stockholders equity | 290 | 146 | 147 | 156 | 117 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Stock-based compensation expense | 4 | 8 | 9 | 5 | 6 | |
| Depreciation and amortization expense | 1 | 796,000 | 419,000 | 513,000 | 499,000 | |
| Non-cash lease expense | 3 | 2 | 2 | 1 | 1 | |
| Accretion of debt discount | 865,000 | 856,000 | 929,000 | 918,000 | 756,000 | |
| Change in fair value of warrant liability | −13 | −2 | −7 | 3 | 366,000 | |
| Other | −161,000 | −639,000 | −227,000 | 37,000 | 337,000 | |
| Accounts receivable | 497,000 | −1 | 0 | 0 | — | |
| Inventory | −2 | −3 | 0 | 0 | — | |
| Prepaid expenses, other current and non-current assets and research and development incentive receivable | 4 | 683,000 | −1 | −610,000 | −2 | |
| Accounts payable | −3 | −286,000 | 1 | 3 | 1 | |
| Accrued expenses and other long-term liabilities | −2 | 7 | 2 | 4 | −152,000 | |
| Deferred revenue | 1 | 0 | 0 | — | — | |
| Lease liabilities | −2 | −1 | −1 | −882,000 | −698,000 | |
| Net cash used in operating activities | −86 | −131 | −97 | −77 | −71 | |
| Acquisition of intangible asset | −3 | −7 | 0 | — | — | |
| Proceeds from sale of non-financial asset | 0 | 105 | 0 | — | — | |
| Purchase of marketable securities | −63 | −57 | −17 | 0 | 0 | |
| Sales and maturities of marketable securities | 75 | 26 | 2 | 0 | 0 | |
| Acquisition of property and equipment | 0 | −326,000 | −60,000 | −103,000 | −615,000 | |
| Net cash provided by (used in) investing activities | 8 | 67 | −15 | −103,000 | −615,000 | |
| Proceeds from exercise of stock options, warrants, and pre-funded warrants and issuance of shares of common stock under employee stock purchase plan | 98,000 | 294,000 | 9 | — | — | |
| Proceeds from borrowings under loan and security agreement | 0 | 20 | 23 | 0 | 0 | |
| Repayments of borrowings under loan and security agreement | 0 | 0 | −2 | −795,000 | 0 | |
| Issuance costs for amendments to loan and security agreement and for the sale of warrants accounted as a liability | 0 | 0 | −631,000 | −5 | 0 | |
| Proceeds from sale of shares of common stock, warrants and pre-funded warrants, less issuance costs | 239 | 0 | 60 | — | — | |
| Net cash provided by financing activities | 239 | 20 | 89 | 117 | 74 | |
| Effect of exchange rate changes on cash, cash equivalents and restricted cash | 213,000 | −156,000 | 99,000 | −105,000 | −319,000 | |
| Net increase (decrease) in cash, cash equivalents and restricted cash | 161 | −44 | −23 | 40 | 2 | |
| Acquisition of intangible assets included in accrued expenses | 500,000 | 4 | 0 | — | — | |
| Cash paid for interest | 8 | 8 | 5 | 3 | 3 |