Xenetic Biosciences, Inc.
Business
Xenetic Biosciences, Inc. is a biopharmaceutical company focused on advancing immuno-oncology technologies that target neutrophil extracellular traps (NETs) to improve outcomes of difficult‑to‑treat solid tumors. It develops a proprietary DNase program (including systemic IV rhDNase I and DNase‑armored CAR T approaches) and licenses a polysialic acid‑based PolyXen drug‑delivery platform. Its activities encompass internal R&D, academic and industry collaborations, licensing and sublicensing, and reliance on contract manufacturers and CROs. It pursues clinical development and regulatory pathways in the U.S., Europe and other jurisdictions and commercializes through partners, licenses and contract manufacturing channels.
Summary from filing dated 2025-03-18
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Royalty revenue | 3 | 3 | 3 | 2 | 1 | |
| Total revenue | 3 | 3 | 3 | 2 | 1 | |
| Research and development | −3 | −3 | −3 | −5 | −3 | |
| General and administrative | −3 | −3 | −4 | −4 | −4 | |
| Total operating costs and expenses | −6 | −7 | −7 | −8 | −7 | |
| Loss from operations | −3 | −4 | −5 | −7 | −6 | |
| Other income (expense) | 5,725 | −5,708 | 25,380 | −1,597 | 1,119 | |
| Interest income, net | 147,997 | 249,861 | 355,757 | 167,152 | 100,467 | |
| Total other income, net | 153,722 | 244,153 | 381,137 | 165,555 | 101,586 | |
| Net loss | −3 | −4 | −4 | −7 | −6 | |
| Basic net loss per share | −1.58 | −2.57 | −2.71 | −4.61 | −0.55 | |
| Diluted net loss per share | −1.58 | −2.57 | −2.71 | −4.61 | −0.55 | |
| Weighted-average shares of common stock outstanding, basic | 2 | 2 | 2 | 1 | 10 | |
| Weighted-average shares of common stock outstanding, diluted | 2 | 2 | 2 | 1 | 10 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash | 8 | 6 | 9 | — | — | |
| Prepaid expenses and other | 166,294 | 421,954 | 603,828 | 556,094 | 479,399 | |
| Total current assets | 8 | 7 | 10 | 14 | 19 | |
| Other assets | 313,921 | 313,921 | 1 | 1 | 1 | |
| Total assets | 8 | 7 | 11 | 15 | 20 | |
| Accounts payable | 258,109 | 283,615 | 240,832 | 287,360 | 362,470 | |
| Accrued expenses and other current liabilities | 709,916 | 610,648 | 568,753 | 785,796 | 1 | |
| Total current liabilities | 968,025 | 894,263 | 809,585 | 1 | 1 | |
| Total liabilities | 968,025 | 894,263 | 809,585 | 1 | 1 | |
| Commitments and contingencies (Note 11) | — | — | — | — | — | |
| Common stock, $0.001 par value; 10,000,000 shares authorized as of December 31, 2025 and December 31, 2024; 2,293,757 and 1,544,840 shares issued as of December 31, 2025 and December 31, 2024, respectively; 2,291,056 and 1,542,139 shares outstanding as of December 31, 2025 and December 31, 2024, respectively | 2,294 | 1,545 | 1,544 | 1,520 | 13,465 | |
| Additional paid in capital | 212 | 208 | 208 | 208 | 206 | |
| Accumulated deficit | −200 | −197 | −193 | −189 | −183 | |
| Accumulated other comprehensive income | 253,734 | 253,734 | 253,734 | 253,734 | 253,734 | |
| Treasury stock | −5 | −5 | −5 | −5 | — | |
| Total stockholders' equity | 7 | 6 | 10 | 14 | 18 | |
| Total liabilities and stockholders' equity | 8 | 7 | 11 | 15 | 20 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Share-based expense | 64,787 | 171,814 | 283,085 | 511,480 | 410,437 | |
| Prepaid expenses and other | 255,660 | 181,874 | −47,734 | −103,738 | 286,007 | |
| Other long-term assets | 0 | 704,431 | 48,579 | 25,000 | −281,946 | |
| Accounts payable, accrued expenses and other current liabilities | 73,762 | 84,678 | −263,571 | −347,947 | 457,132 | |
| Net cash used in operating activities | −2 | −3 | −4 | −5 | −5 | |
| Net proceeds from issuance of common stock in October 2025 underwritten public offering | 4 | 0 | — | 0 | 11 | |
| Net cash provided by financing activities | 4 | 0 | — | 0 | 11 | |
| Net change in cash | 2 | −3 | −4 | −5 | 7 | |
| Cash paid for interest | 0 | 0 | 0 | 0 | 0 | |
| Issuance of common stock from cashless exercise of purchase warrants | 0 | 1 | 0 | 2 | 6 | |
| Conversion of Series B preferred stock to common stock | 350 | 0 | — | — | — |