Intellia Therapeutics, Inc.
Business
Intellia Therapeutics, Inc. is a clinical-stage biotechnology company developing CRISPR-based genome editing therapies. It primarily offers in vivo CRISPR/Cas9 therapies delivered via lipid nanoparticle (LNP) technology, including lead candidates nexiguran ziclumeran (nex-z) and NTLA-2002, and ex vivo engineered cell therapy candidates using LNP-based cell engineering and allogeneic editing approaches. Its operations are organized around in vivo programs, ex vivo programs and platform research, supported by strategic collaborations and licensing arrangements. Intellia conducts global clinical development and works with partners for regulatory approvals and commercialization across major markets including the U.S., EU and U.K.
Summary from filing dated 2025-02-27
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Collaboration revenue | 68 | 58 | 36 | 52 | 33 | |
| Research and development | 389 | 466 | 435 | 420 | 230 | |
| General and administrative | 120 | 126 | 116 | 90 | 71 | |
| Total operating expenses | 509 | 592 | 552 | 510 | 301 | |
| Operating loss | −441 | −534 | −515 | −458 | −268 | |
| Interest income | 29 | 48 | 50 | 9 | 1 | |
| Change in fair value of investments, net | −899,000 | −33 | 0 | 0 | — | |
| Loss from equity method investment | 0 | 0 | −16 | −11 | −1 | |
| Change in fair value of contingent consideration | 0 | 0 | −100,000 | −13 | 0 | |
| Total other income, net | 28 | 15 | 34 | −16 | −42,000 | |
| Net loss | −413 | −519 | −481 | −474 | −268 | |
| Net loss per share, basic | −3.81 | −5.25 | −5.42 | −6.16 | −3.78 | |
| Net loss per share, diluted | −3.81 | −5.25 | −5.42 | −6.16 | −3.78 | |
| Weighted average shares outstanding, basic | 108 | 99 | 89 | 77 | 71 | |
| Weighted average shares outstanding, diluted | 108 | 99 | 89 | 77 | 71 | |
| Unrealized gain on marketable securities | 427,000 | 731,000 | 4 | −2 | −2 | |
| Other comprehensive gain from equity method investment | 0 | 0 | 2 | −3 | — | |
| Comprehensive loss | −412 | −518 | −476 | −479 | −271 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 155 | 189 | 227 | 524 | 123 | |
| Marketable securities | 294 | 412 | 685 | 669 | 625 | |
| Accounts receivable | 9 | 9 | 36 | 4 | 2 | |
| Prepaid expenses and other current assets | 68 | 30 | 50 | 20 | 19 | |
| Total current assets | 528 | 640 | 998 | 1,217 | 769 | |
| Marketable securities - noncurrent | 155 | 260 | 100 | 69 | 337 | |
| Property and equipment, net | 18 | 27 | 33 | 28 | 21 | |
| Operating lease right-of-use assets | 106 | 219 | 115 | 133 | 79 | |
| Investments and other assets | 36 | 44 | 43 | 41 | 30 | |
| Total assets | 842 | 1,191 | 1,301 | 1,520 | 1,294 | |
| Accounts payable | 20 | 15 | 7 | 5 | 10 | |
| Accrued expenses | 50 | 55 | 67 | 61 | 43 | |
| Current portion of operating lease liability | 26 | 20 | 19 | 17 | 9 | |
| Current portion of deferred revenue | 7 | 21 | 22 | 44 | 64 | |
| Total current liabilities | 104 | 111 | 115 | 127 | 126 | |
| Deferred revenue, net of current portion | 0 | 18 | 39 | 20 | 63 | |
| Long-term operating lease liability | 67 | 190 | 97 | 114 | 65 | |
| Total liabilities | 171 | 319 | 251 | 285 | — | |
| Commitments and contingencies (Note 6) | — | — | — | — | — | |
| Common stock, $0.0001 par value; 240,000,000 shares authorized at December 31, 2025 and December 31, 2024; 116,317,060 and 102,029,594 shares issued and outstanding at at December 31, 2025 and December 31, 2024, respectively | 12,000 | 10,000 | 9,000 | 9,000 | 7,000 | |
| Additional paid-in capital | 3,260 | 3,049 | 2,711 | 2,420 | 1,746 | |
| Accumulated other comprehensive income | 1 | 605,000 | −2 | −7 | −3 | |
| Accumulated deficit | −2,590 | −2,177 | −1,658 | −1,177 | −703 | |
| Total stockholders equity | 671 | 872 | 1,050 | 1,236 | 1,040 | |
| Total liabilities and stockholders' equity | 842 | 1,191 | 1,301 | 1,520 | 1,294 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −413 | −519 | −481 | −474 | −268 | |
| Depreciation and amortization | 10 | 10 | 9 | 8 | 7 | |
| Loss (gain) on disposal of property and equipment | 527,000 | −76,000 | 72,000 | −162,000 | 0 | |
| Accelerated amortization/impairment of right-of-use assets | 6 | 0 | 0 | — | — | |
| Stock-based compensation | 80 | 154 | 134 | 91 | 47 | |
| Accretion of investment discounts and premiums | −6 | −18 | −26 | 4 | 8 | |
| (Recognition) deferral of equity method investment intra-entity profit on sales | 0 | −21 | 7 | 11 | — | |
| Accounts receivable | −951,000 | 28 | −33 | −2 | 99,000 | |
| Prepaid expenses and other current assets | −26 | 5 | −27 | −2 | −10 | |
| Operating lease right-of-use assets | 33 | 21 | 19 | 13 | 9 | |
| Other assets | 3 | 917,000 | −707,000 | −1 | 117,000 | |
| Accounts payable | 6 | 7 | 3 | −5 | 529,000 | |
| Accrued expenses | −5 | −10 | 6 | 16 | 17 | |
| Deferred revenue | −28 | −22 | −3 | −63 | −31 | |
| Operating lease liabilities | −55 | −18 | −17 | −10 | −9 | |
| Net cash used in operating activities | −395 | −349 | −394 | −333 | −225 | |
| Purchases of property and equipment | −1 | −6 | −14 | −14 | −13 | |
| Purchases of marketable securities | −323 | −936 | −904 | −429 | −1,021 | |
| Sales and maturities of marketable securities | 552 | 1,067 | 887 | 648 | 486 | |
| Net cash provided by (used in) investing activities | 228 | 126 | −31 | 160 | −551 | |
| Net proceeds from issuance of common stock | 128 | 177 | 120 | — | 1,818 | |
| Proceeds from options exercised | 722,000 | 6 | 7 | 15 | 41 | |
| Issuance of shares through employee stock purchase plan | 3 | 3 | 4 | 3 | 2 | |
| Net cash provided by financing activities | 131 | 186 | 130 | 583 | 737 | |
| Net (decrease) increase in cash, cash equivalents and restricted cash equivalents | −35 | −38 | −295 | 410 | −39 | |
| Purchases of property and equipment unpaid at period end | 32,000 | 577,000 | 2 | 2 | 667,000 | |
| Reduction of right-of-use assets from remeasurement of lease liabilities | 62 | 0 | 0 | — | — | |
| Operating lease liabilities arising from obtaining right-of-use assets | 0 | 113 | 1 | 67 | — | |
| Non-cash trade-in of property and equipment | 0 | 99,000 | 0 | 200,000 | 0 | |
| Proceeds from at-the-market offerings unpaid at period end | 0 | 0 | 2 | 0 | 0 |