Amylyx Pharmaceuticals, Inc.

Listed Company

AMLXCIK 0001658551NasdaqNon-AcceleratedSmaller ReportingPharmaceutical PreparationsDelawareFY ends Dec 31

Period

FY 2025

Revenue

Net Income

$-144.74M

Total Assets

$332.64M

Equity

$305.26M

Shares Out

110.54M

Op. Cash Flow

$-123.34M

Business

Amylyx Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company developing novel therapies for neurodegenerative diseases and endocrine conditions. Its main product candidates include avexitide, a GLP-1 receptor antagonist for post‑bariatric hypoglycemia and congenital hyperinsulinism; AMX0035, an oral fixed‑dose combination targeting ER stress and mitochondrial dysfunction for Wolfram syndrome and PSP; and AMX0114, an antisense oligonucleotide targeting CAPN2 for ALS, alongside discovery collaborations for long‑acting GLP‑1 antagonists. The company operates core functions in clinical and preclinical development, intellectual property management, and external manufacturing partnerships. It conducts multinational clinical trials and regulatory interactions primarily in the U.S., EU, Canada and other jurisdictions and utilizes contract research organizations, contract manufacturers and healthcare providers for development, supply and eventual commercialization.

Summary from filing dated 2025-03-04

Financials

Consolidated Statement of Income

Year Ended · In millions, except per-share amounts

Concept	FY 2025 2025-12-31	FY 2024 2024-12-31	FY 2023 2023-12-31	FY 2022 2022-12-31	FY 2021 2021-12-31
Product revenue, net	0	87	381	22	—
Cost of sales	0	6	25	3	—
Cost of sales - inventory impairment and loss on firm purchase commitments	0	119	—	—	—
Acquired in-process research and development	0	36	—	—	—
Research and development	90	104	128	93	44
Selling, general and administrative	63	114	188	127	39
Restructuring expenses	0	23	—	—	—
Total operating expenses	153	402	342	224	83
Loss from operations	−153	−315	39	−201	−83
Interest income	9	14	16	4	36,000
Other expense, net	−700,000	−1	−660,000	−551,000	−51,000
Total other income, net	9	13	15	4	−5
Loss before income taxes	−145	−302	54	−198	−88
Provision (benefit) for income taxes	46,000	−393,000	5	774,000	—
Net loss	−145	−302	49	−198	−88
Net loss per share - basic	−1.53	−4.43	0.73	−3.39	−13.35
Net loss per share - diluted	−1.53	−4.43	0.7	−3.39	−13.35
Weighted-average shares used in computing net loss per share - basic	95	68	67	58	7
Weighted-average shares used in computing net loss per share - diluted	95	68	70	58	7

Consolidated Balance Sheet

As of · In millions, except per-share amounts

Concept	FY 2025 2025-12-31	FY 2024 2024-12-31	FY 2024 2024-08-31	FY 2023 2023-12-31	FY 2022 2022-12-31
Cash and cash equivalents	227	77	—	170	63
Marketable securities	90	99	—	201	—
Accounts receivable, net	88,000	447,000	—	40	15
Prepaid expenses and other current assets	7	12	—	15	10
Total current assets	324	189	—	465	382
Property and equipment, net	310,000	961,000	—	3	3
Restricted cash equivalents	985,000	1	—	719,000	700,000
Operating lease right-of-use assets	5	2	5	4	6
Deposits and other assets	2	24,000	—	—	—
Total assets	333	194	—	517	391
Accounts payable	4	3	—	22	6
Accrued expenses	18	24	—	58	38
Operating lease liabilities, current portion	1	2	—	2	2
Total current liabilities	23	28	—	82	47
Operating lease liabilities, net of current portion	5	463,000	—	2	4
Total liabilities	27	29	—	84	51
Commitments and contingencies (Note 16)	—	—	—	—	—
Common stock, $0.0001 par value; 300,000,000 shares authorized; 109,884,502 and 68,629,738 shares issued and outstanding as of December 31, 2025 and 2024, respectively	11,000	7,000	—	7,000	7,000
Additional paid-in capital	1,056	772	—	738	695
Accumulated deficit	−751	−607	—	−305	−354
Accumulated other comprehensive income (loss)	404,000	−92,000	—	197,000	−86,000
Total stockholders' equity	305	165	—	433	341
Total liabilities and stockholders' equity	333	194	—	517	391

Consolidated Statement of Cash Flows

Year Ended · In millions, except per-share amounts

Concept	FY 2025 2025-12-31	FY 2024 2024-12-31	FY 2023 2023-12-31	FY 2022 2022-12-31	FY 2021 2021-12-31
Net loss	−145	−302	49	−198	−88
Stock-based compensation expense	28	33	37	22	3
Depreciation expense	525,000	904,000	1	487,000	52,000
Accretion of investment discounts, net	−6	−10	−10	−2	121,000
Charge for purchase of IPR&D assets	—	36	—	—	—
Other non-cash items	−169,000	958,000	—	—	—
Accounts receivable, net	359,000	40	−25	−15	—
Inventories	—	−9	−73	−10	—
Interest receivable	24,000	359,000	23,000	487,000	−144,000
Prepaid expenses and other current assets	6	2	−3	−5	−4
Operating lease right-of-use assets	2	2	2	2	—
Deposits and other assets	−2	677,000	—	—	—
Accounts payable	580,000	−19	16	2	670,000
Accrued expenses	−7	−60	22	—	—
Operating lease liabilities	−1	−2	−2	−917,000	—
Net cash used in operating activities	−123	−168	12	−180	−75
Purchases of property and equipment	−138,000	−157,000	−1	−3	−353,000
Purchases of IPR&D assets, including transaction costs	—	−36	—	—	—
Purchases of investments	−232	−232	−301	−416	−49
Proceeds from maturities of marketable securities	246	344	394	179	3
Net cash provided by investing activities	14	76	92	−239	−46
Proceeds from financings, net of issuance costs	256	—	—	—	12
Proceeds from exercise of stock options and RSUs vesting	4	2	7	—	—
Withholding taxes paid on stock-based awards	−3	−2	−3	—	—
Net cash provided by financing activities	257	348,000	4	432	159
Effect of exchange rate changes on cash, cash equivalents and restricted cash equivalents	1	−438,000	160,000	−65,000	13,000
Net increase (decrease) increase in cash, cash equivalents and restricted cash equivalents	149	−92	108	13	37
Other assets included in accounts payable and accrued expenses	500,000	—	—	—	—
Right-of-use assets obtained in exchange for new operating lease liabilities	5	—	—	5	—

Filings

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