Immunocore Holdings plc
Business
Immunocore Holdings plc is a commercial-stage biotechnology company that pioneers and delivers engineered T cell receptor (TCR)–based immunotherapies to treat cancer, infectious diseases, and autoimmune conditions. Its main products and candidates include the approved ImmTAC therapy KIMMTRAK (tebentafusp) for unresectable or metastatic uveal melanoma and a pipeline of bispecific TCR molecules such as brenetafusp and infectious- and autoimmune-targeted ImmTAV and ImmTAAI candidates. The company organizes activities around its ImmTAX platform and three platform families (ImmTAC, ImmTAV, ImmTAAI) supporting discovery, clinical development and commercialization. It commercializes products via an in-house U.S. sales force, contracted commercial resources in the U.S. and Europe, and multi-regional distributor agreements for other territories.
Summary from filing dated 2025-02-26
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenue | 400 | 310 | 249 | 174 | 4 | |
| Cost of revenue from sale of therapies | −5 | −3 | −1 | −1 | 0 | |
| Research and development expense | −275 | −222 | −164 | −102 | −100 | |
| Selling, general and administrative expense | −165 | −156 | −144 | −123 | −111 | |
| Loss from operations | −45 | −70 | −60 | −52 | −175 | |
| Interest income | 16 | 26 | 18 | 4 | 65,000 | |
| Interest expense | −12 | −19 | −5 | −5 | — | |
| Foreign currency gain (loss) | 2 | −3 | −13 | 14 | 289,000 | |
| Other income (expense), net | 20 | 14 | −897,000 | −2 | −73,000 | |
| Net loss before income taxes | −19 | −53 | −61 | −41 | −180 | |
| Income tax (expense) benefit | −16 | 2 | 6 | −12 | −150,000 | |
| Net loss | −36 | −51 | −55 | −53 | −180 | |
| Exchange differences on translation of foreign operations | 6 | 2 | 18 | −24 | −254,000 | |
| Total comprehensive loss | −30 | −49 | −37 | −77 | −180 | |
| Basic net loss per share (in dollars per share) | −0.71 | −1.02 | −1.13 | −1.15 | −4.24 | |
| Diluted net loss per share (in dollars per share) | −0.71 | −1.02 | −1.13 | −1.15 | −4.24 | |
| Basic weighted-average number of shares outstanding (in shares) | 50 | 50 | 49 | 46 | 42 | |
| Diluted weighted-average number of shares outstanding (in shares) | 50 | 50 | 49 | 46 | 42 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2023 2023-10-31 | FY 2022 2022-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 468 | 456 | 443 | — | 402 | |
| Marketable securities | 396 | 365 | 0 | — | — | |
| Accounts receivable, net | 74 | 63 | 52 | — | — | |
| Prepaid expenses and other current assets | 50 | 41 | 30 | — | 37 | |
| Tax receivable | 2 | 0 | — | — | — | |
| Inventory, net | 7 | 5 | 5 | — | 692,000 | |
| Total current assets | 997 | 930 | 529 | — | 474 | |
| Property and equipment, net | 11 | 10 | 9 | — | 8 | |
| Operating lease right of use assets, net | 39 | 38 | 34 | 6 | 31 | |
| Deferred tax assets, net | 0 | 15 | 11 | — | 5 | |
| Other non-current assets | 20 | 17 | 14 | — | 9 | |
| Total assets | 1,067 | 1,010 | 597 | — | 527 | |
| Accounts payable | 24 | 25 | 18 | — | 14 | |
| Accrued expenses and other current liabilities | 220 | 186 | 120 | — | 77 | |
| Deferred revenue, current | 583,000 | 0 | — | — | — | |
| Operating lease liabilities, current | 2 | 2 | 1 | — | 2 | |
| Total current liabilities | 247 | 212 | 139 | — | 101 | |
| Deferred revenue, non-current | 5 | 5 | — | — | — | |
| Operating lease liabilities, non-current | 42 | 40 | 36 | — | 32 | |
| Interest-bearing loans and borrowings | 393 | 391 | 48 | — | 48 | |
| Total liabilities | 686 | 649 | 228 | — | 188 | |
| Commitments and contingencies (Note 14) | — | — | — | — | — | |
| Ordinary shares (voting and non-voting), 0.002 par value, most recent authority to allot up to a maximum nominal value of 149,633 and 97,454 shares as of December 31, 2025 and 2024, respectively, and 50,689,271 and 50,064,860 shares issued and outstanding as of December 31, 2025 and 2024, respectively. | 136,000 | 135,000 | 134,000 | — | 129,000 | |
| Deferred shares, 0.0001 par value, 5,793,501 shares authorized, issued and outstanding as of December 31, 2025 and 2024. | 1,000 | 1,000 | 1,000 | — | 1,000 | |
| Additional paid-in capital | 1,240 | 1,190 | 1,150 | — | 1,083 | |
| Accumulated deficit | −831 | −796 | −745 | — | −689 | |
| Accumulated other comprehensive loss | −28 | −34 | −36 | — | −55 | |
| Total shareholders equity | 381 | 361 | 369 | — | 339 | |
| Total liabilities and shareholders equity | 1,067 | 1,010 | 597 | — | 527 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Share-based compensation expense | 38 | 34 | 32 | 33 | 49 | |
| Depreciation | 3 | 4 | 4 | 5 | 8 | |
| Unrealized foreign exchange losses (gains) | −6 | 599,000 | 14 | −14 | 99,000 | |
| Unrealized gains on marketable securities | −20 | −15 | 0 | 0 | — | |
| Loss on loan extinguishment | 0 | 4 | 0 | 2 | 0 | |
| Non-cash lease expense | 2 | 2 | 2 | 2 | 2 | |
| Deferred income taxes | 15 | −4 | −6 | — | — | |
| Other | 2 | 2 | 412,000 | −4,000 | 222,000 | |
| Increase in accounts receivable | −7 | −12 | −18 | −26 | −5 | |
| (Increase) decrease in prepayments and other current assets | −7 | −12 | 9 | −15 | 1 | |
| (Decrease) increase in accounts payable | −2 | 7 | 3 | 5 | 1 | |
| Increase in accrued expenses | 16 | 72 | 39 | 42 | 11 | |
| Decrease in deferred revenue | −387,000 | −1,000 | −8 | — | — | |
| Decrease in operating lease liabilities | −2 | −2 | −2 | −2 | −2 | |
| Increase in other operating assets | −6 | −4 | −9 | −5 | 361,000 | |
| Decrease in other operating liabilities | 0 | 0 | −1 | 2 | 123,000 | |
| Net cash (used in) provided by operating activities | −11 | 26 | 3 | −49 | −143 | |
| Proceeds from sale of property, plant and equipment | 0 | 44,000 | 0 | 6,000 | 106,000 | |
| Proceeds from sale of marketable securities | 18 | 0 | 0 | — | — | |
| Purchase of marketable securities | −30 | −350 | 0 | 0 | — | |
| Purchase of property, plant and equipment | −4 | −5 | −5 | −2 | −1 | |
| Net cash used in investing activities | −16 | −355 | −5 | −2 | −1 | |
| Proceeds from issue of ordinary shares, net | 0 | 0 | 0 | 140 | 287 | |
| Exercise of share options | 12 | 7 | 34 | 10 | 1 | |
| Loan repayments | 0 | −50 | 0 | −50 | 0 | |
| Debt prepayments and extinguishments | 0 | −2 | 0 | −2 | 0 | |
| Non-current interest-bearing loan received | 0 | 403 | 0 | 50 | 0 | |
| Debt issuance payments | 0 | −13 | 0 | −2 | 0 | |
| Net cash provided by financing activities | 12 | 344 | 34 | 145 | 288 | |
| (Decrease) increase in net cash and cash equivalents | −15 | 15 | 32 | 94 | 144 | |
| Net foreign exchange difference on cash held | 27 | −2 | 8 | −13 | 625,000 | |
| Cash (paid)/ received for interest, net | −10 | −9 | 6 | −4 | −6 | |
| Cash paid for income taxes, net | −5 | −510,000 | −977,000 | −765,000 | 17 |