Enliven Therapeutics, Inc.
Business
Enliven Therapeutics, Inc. is a clinical-stage biopharmaceutical company that discovers and develops small molecule therapeutics using a precision oncology, chemistry-led approach. It advances lead product candidates ELVN-001, a selective BCR-ABL kinase inhibitor for chronic myeloid leukemia, and ELVN-002, a CNS-penetrant, irreversible HER2 inhibitor, along with multiple discovery-stage small molecule programs. Its key business areas include its BCR-ABL and HER2 development programs, target- and indication-agnostic discovery efforts, and clinical development operations. It conducts clinical trials in multiple geographies (including the United States and Japan), holds worldwide development and commercial rights, and relies on third-party contract manufacturing and CRO partnerships for supply and distribution.
Summary from filing dated 2025-03-13
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 86 | 81 | 65 | 31 | 38 | |
| General and administrative | 34 | 24 | 19 | 8 | 13 | |
| Total operating expenses | 120 | 105 | 84 | 39 | 51 | |
| Loss from operations | −120 | −105 | −84 | −39 | −51 | |
| Interest income | 16 | 15 | 12 | 1 | 233,000 | |
| Change in fair value of contingent value right liability | 0 | 873,000 | 0 | — | — | |
| Income tax expense | 0 | −232,000 | 0 | 88,000 | — | |
| Other expense | −49,000 | −2,000 | −22,000 | 0 | −175,000 | |
| Total other income (expense), net | 16 | 16 | 12 | 1 | 58,000 | |
| Net loss | −104 | −89 | −72 | −38 | −51 | |
| Net unrealized gains (losses) on marketable securities | 279,000 | −86,000 | 141,000 | 0 | −20,000 | |
| Comprehensive loss | −103 | −89 | −71 | −38 | −51 | |
| Net loss per share, basic | −1.83 | −1.89 | −2.01 | −12.05 | −2.37 | |
| Net loss per share, diluted | −1.83 | −1.89 | −2.01 | −12.05 | −2.37 | |
| Weighted-average shares outstanding, basic | 57 | 47 | 36 | 3 | 22 | |
| Weighted-average shares outstanding, diluted | 57 | 47 | 36 | 3 | 22 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2025 2025-01-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2023 2023-02-28 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 99 | — | 124 | 100 | — | |
| Marketable securities | 364 | — | 189 | 153 | — | |
| Restricted cash | 0 | — | 54,000 | 54,000 | — | |
| Prepaid expenses and other current assets | 12 | — | 5 | 3 | — | |
| Total current assets | 475 | — | 318 | 266 | — | |
| Property and equipment, net | 34,000 | — | 458,000 | 742,000 | — | |
| Operating lease right-of-use assets | 383,000 | 700,000 | 0 | 320,000 | — | |
| Deferred offering costs | 217,000 | — | 0 | 563,000 | — | |
| Other long-term assets | 656,000 | — | 7 | 4 | — | |
| Total assets | 476 | — | 326 | 272 | — | |
| Accounts payable | 2 | — | 1 | 532,000 | — | |
| Accrued expenses and other current liabilities | 14 | — | 15 | 15 | — | |
| Total current liabilities | 17 | — | 16 | 26 | — | |
| Total liabilities | 17 | — | 16 | 26 | — | |
| Commitments and contingencies (Note 8) | — | — | — | — | — | |
| Preferred stock, par value $0.001; authorized shares - 10,000,000; issued and outstanding shares - none | 0 | — | 0 | 0 | — | |
| Common stock, par value $0.001; authorized shares - 100,000,000; issued and outstanding shares - 59,440,045 and 48,936,459 at December 31, 2025 and 2024, respectively | 59,000 | — | 49,000 | 41,000 | 165 | |
| Additional paid-in capital | 806 | — | 553 | 400 | — | |
| Accumulated other comprehensive income | 334,000 | — | 55,000 | 141,000 | — | |
| Accumulated deficit | −347 | — | −243 | −154 | — | |
| Total stockholders' equity | 460 | — | 310 | 246 | — | |
| Total liabilities and stockholders' equity | 476 | — | 326 | 272 | — |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Depreciation | 263,000 | 317,000 | 297,000 | 215,000 | 100,000 | |
| Stock-based compensation | 34 | 20 | 13 | 3 | 4 | |
| Non-cash lease expense | 353,000 | 320,000 | 306,000 | 0 | — | |
| Amortization of premiums and discounts on marketable securities, net | −227,000 | 424,000 | −5 | 0 | 155,000 | |
| Loss on disposal of property and equipment | 106,000 | 11,000 | — | — | — | |
| Prepaid expenses, other current and long-term assets | −1 | −5 | −4 | −2 | −235,000 | |
| Operating lease liabilities | −337,000 | −335,000 | −310,000 | 4,000 | — | |
| Accounts payable | 817,000 | 810,000 | −2 | 411,000 | 389,000 | |
| Accrued expenses and other liabilities | −496,000 | −248,000 | 8 | 2 | 393,000 | |
| Net cash used in operating activities | −70 | −73 | −61 | −32 | −47 | |
| Maturities of marketable securities | 273 | 314 | 120 | 0 | — | |
| Purchases of marketable securities | −447 | −351 | −268 | 0 | — | |
| Receipt of contingent value right milestone | 0 | 10 | 0 | — | — | |
| Payment of contingent value right milestone, net of permitted deductions | 0 | −9 | 0 | — | — | |
| Purchases of property and equipment | −158,000 | −44,000 | −149,000 | −612,000 | −12,000 | |
| Proceeds from sale of property and equipment | 213,000 | 0 | — | — | — | |
| Net cash used in investing activities | −174 | −36 | −148 | −612,000 | −2 | |
| Proceeds from exercise of stock options | 2 | 4 | 399,000 | 591,000 | 860,000 | |
| Proceeds from issuance of common stock under the Employee Stock Purchase Plan | 620,000 | 651,000 | 0 | — | — | |
| Proceeds from issuance of common stock and pre-funded warrants in the Public Offering, net of issuance costs | 216 | 0 | — | — | — | |
| Proceeds from issuance of common stock and Pre-Funded Warrants in the Private Placement, net of issuance costs | 0 | 90 | 0 | — | — | |
| Proceeds from issuance of common stock under the Sales Agreement, net of issuance costs | 0 | 39 | 0 | — | — | |
| Payment of deferred offering costs | −217,000 | 0 | — | — | — | |
| Net cash provided by financing activities | 219 | 133 | 234 | −2 | 49 | |
| Net (decrease) increase in cash, cash equivalents and restricted cash | −25 | 24 | 25 | −34 | 698,000 | |
| Income taxes paid related to the contingent value right milestone | 0 | 232,000 | 0 | — | — | |
| Operating lease right-of-use assets obtained in exchange for operating lease liabilities | 736,000 | 0 | — | — | — |