Arcus Biosciences, Inc.
Business
Arcus Biosciences, Inc. develops clinical-stage biopharmaceutical therapies focused on oncology and immuno-oncology. Its main products are investigational small molecules and antibodies, including programs targeting TIGIT, PD-1, HIF-2α, adenosine A2a/A2b receptors, CD73, CD39 and AXL (e.g., domvanalimab, zimberelimab, casdatifan, etrumadenant, quemliclustat, AB598, AB801). The company operates as a single reportable operating segment centered on discovery, clinical development and advancement of combination regimens. It distributes investigational products through strategic collaborations and third-party manufacturers, with commercialization rights managed via partners across U.S., Asia and other global territories.
Summary from filing dated 2025-02-25
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Total revenues | 247 | 258 | 117 | 112 | — | |
| Research and development (Includes $25, ($39) and ($110) payments to/(from) a related party) | 523 | 448 | 340 | 288 | 257 | |
| General and administrative (Includes $5, $2 and $ payments to a related party) | 110 | 120 | 117 | 104 | 72 | |
| Impairment of long-lived assets (see Note 14, Leases) | 0 | 20 | 0 | 0 | — | |
| Total operating expenses | 633 | 588 | 457 | 392 | 329 | |
| Loss from operations | −386 | −330 | −340 | −280 | 54 | |
| Interest and other income, net | 41 | 52 | 41 | 16 | 1 | |
| Interest expense | −8 | −4 | −2 | −2 | — | |
| Total non-operating income, net | 33 | 48 | 39 | 14 | 1 | |
| Loss before income taxes | −353 | −282 | −301 | −266 | 55 | |
| Income tax expense | 0 | −1 | −6 | −1 | −2 | |
| Net loss | −353 | −283 | −307 | −267 | 53 | |
| Net loss per share, basic (in dollars per share) | −3.29 | −3.14 | −4.15 | −3.71 | — | |
| Net loss per share, diluted (in dollars per share) | −3.29 | −3.14 | −4.15 | −3.71 | — | |
| Shares used to compute net loss per share, basic (in shares) | 107 | 90 | 74 | 72 | 69 | |
| Shares used to compute net loss per share, diluted (in shares) | 107 | 90 | 74 | 72 | 74 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 222 | 150 | 127 | 206 | 148 | |
| Marketable securities | 759 | 828 | 632 | 803 | 351 | |
| Receivable from collaboration partners ($ and $6 from a related party) | 11 | 20 | 38 | 39 | 745 | |
| Prepaid expenses and other current assets | 15 | 18 | 34 | 19 | 18 | |
| Total current assets | 1,007 | 1,016 | 831 | 1,067 | 1,262 | |
| Long-term marketable securities | 29 | 14 | 107 | 129 | 182 | |
| Property and equipment, net | 40 | 47 | 51 | 35 | 32 | |
| Other noncurrent assets | 63 | 73 | 106 | 114 | 116 | |
| Total assets | 1,139 | 1,150 | 1,095 | 1,345 | 1,592 | |
| Accounts payable ($24 and $ to a related party) | 42 | 18 | 17 | 20 | 10 | |
| Deferred revenue ($35 and $85 to a related party) | 35 | 85 | 91 | 97 | 102 | |
| Other current liabilities | 154 | 123 | 76 | 76 | 54 | |
| Total current liabilities | 231 | 226 | 184 | 193 | 166 | |
| Deferred revenue, noncurrent ($43 and $234 to a related party) | 43 | 234 | 307 | 355 | 462 | |
| Long-term debt | 99 | 48 | 0 | — | — | |
| Other noncurrent liabilities | 135 | 157 | 142 | 140 | 122 | |
| Commitments (Note 17) | — | — | — | — | — | |
| Common stock and additional paid-in capital: $0.0001 par value per share; 400.0 shares authorized; 125.3 shares in 2025 and 92.2 shares in 2024 issued and outstanding | 2,116 | 1,617 | 1,311 | 1,206 | 1,118 | |
| Accumulated deficit | −1,485 | −1,132 | −849 | −542 | −275 | |
| Total stockholders equity | 631 | 485 | 462 | 657 | 842 | |
| Total liabilities and stockholders equity | 1,139 | 1,150 | 1,095 | 1,345 | 1,592 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −353 | −283 | −307 | −267 | 53 | |
| Stock-based compensation expense | 60 | 76 | 73 | 65 | 55 | |
| Depreciation and amortization | 10 | 10 | 8 | 6 | 4 | |
| Noncash lease expense | 7 | 7 | 8 | 8 | 3 | |
| Amortization of discounts on marketable securities | −13 | −25 | −19 | 0 | 5 | |
| Other items, net | 1 | 3 | 2 | 3 | 0 | |
| Receivable from collaboration partners ($6, $14 and $19 from a related party) | 9 | 28 | 15 | 704 | −17 | |
| Other assets ($, $6 and ($4) from a related party) | 5 | 22 | −14 | 2 | −3 | |
| Accounts payable ($24, $, and $ to a related party) | 24 | 3 | −1 | 8 | −5 | |
| Deferred revenue (($240), ($56) and ($77) to a related party) | −240 | −56 | −68 | −112 | −368 | |
| Other liabilities | 8 | 25 | −3 | 21 | 17 | |
| Net cash used in operating activities | −482 | −170 | −306 | 438 | −256 | |
| Purchases of marketable securities | −1,076 | −1,043 | −788 | −1,241 | −719 | |
| Proceeds from maturities of marketable securities | 1,073 | 929 | 982 | 694 | 690 | |
| Proceeds from sales of marketable securities | 71 | 36 | 24 | 143 | 51 | |
| Purchases of property and equipment | −2 | −6 | −24 | −6 | −26 | |
| Net cash provided by (used in) investing activities | 66 | −84 | 194 | −413 | −4 | |
| Proceeds from issuance of common stock ($14, $228 and $20 from a related party), net | 429 | 228 | 25 | 0 | 220 | |
| Proceeds from debt issuances, net | 49 | 47 | 0 | 0 | — | |
| Proceeds from issuance of common stock pursuant to equity award plans | 10 | 9 | 8 | 23 | 12 | |
| Payments of employee taxes related to net settlement of equity awards | 0 | −7 | 0 | 0 | — | |
| Net cash provided by financing activities | 488 | 277 | 33 | 33 | 237 | |
| Net increase (decrease) in cash, cash equivalents and restricted cash | 72 | 23 | −79 | 58 | −23 | |
| Income taxes paid | 0 | 0 | 5 | 3 | 0 | |
| Interest paid | 7 | 1 | 0 | 0 | — | |
| Unpaid portion of property and equipment purchases included in Accounts payable and Other current liabilities | 0 | 0 | 2 | 3 | 1 |