IN8BIO, INC.
Business
IN8BIO, INC. is a clinical-stage biopharmaceutical company developing gamma-delta T cell therapies and gamma-delta T cell engagers (TCEs) for cancer and autoimmune diseases. It offers ex vivo expanded and genetically modified allogeneic, autologous and iPSC-derived gamma-delta T cell product candidates and TCEs built on its proprietary DeltEx platform, including clinical programs INB-100, INB-200/400, preclinical INB-300/500 and a TCE program INB-600. Key business activities include clinical development, genetic engineering, scalable cell-type specific manufacturing and licensing. The company conducts investigator- and company-sponsored clinical trials primarily in the United States, uses academic and third-party GMP manufacturing partners, and pursues strategic collaborations for broader commercialization.
Summary from filing dated 2025-03-13
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 10 | 17 | 17 | 14 | 7 | |
| General and administrative | 10 | 13 | 14 | 14 | 7 | |
| Severance and related charges | 0 | 1 | 0 | — | — | |
| Total operating expenses | 20 | 31 | 30 | 29 | 15 | |
| Interest income | 421,000 | 230,000 | 0 | — | — | |
| Loss from operations | −19 | −30 | −30 | −29 | −15 | |
| Net loss | −19 | −30 | −30 | −29 | −15 | |
| Net loss per share - basic | −4.44 | −17.05 | −1 | −1.36 | −1.47 | |
| Net loss per share - diluted | −4.44 | −17.05 | −1 | −1.36 | −1.47 | |
| Weighted-average number of shares used in computing net loss per common share - basic | 4 | 2 | 30 | 21 | 10 | |
| Weighted average number of shares used in computing net loss per share - diluted | 4 | 2 | 30 | 21 | 10 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash | 27 | 11 | 21 | 18 | 37 | |
| Prepaid expenses and other current assets | 788,000 | 1 | 3 | 4 | 2 | |
| Total Current Assets | 28 | 13 | 25 | 22 | 39 | |
| Property and equipment, net | 2 | 3 | 4 | 4 | 97,000 | |
| Restricted cash | 220,000 | 266,000 | 256,000 | 252,000 | 251,000 | |
| Right-of-use assets - finance leases | 296,000 | 1 | 1 | 2 | 704,000 | |
| Right-of-use assets - operating leases | 2 | 4 | 4 | 4 | 2 | |
| Other non-current assets | 146,000 | 275,000 | 255,000 | 255,000 | 158,000 | |
| Total Non-Current Assets | 4 | 8 | 9 | 11 | 3 | |
| Total Assets | 32 | 21 | 34 | 33 | 42 | |
| Accounts payable | 309,000 | 389,000 | 924,000 | 2 | 395,000 | |
| Accrued expenses and other current liabilities | 2 | 1 | 3 | 2 | 1 | |
| Short-term finance lease liability | 295,000 | 694,000 | 694,000 | 682,000 | 392,000 | |
| Short-term operating lease liability | 924,000 | 953,000 | 820,000 | 707,000 | 234,000 | |
| Total Current Liabilities | 3 | 3 | 5 | 6 | 2 | |
| Long-term finance lease liability | 0 | 295,000 | 525,000 | 811,000 | 269,000 | |
| Long-term operating lease liability | 2 | 3 | 3 | 4 | 2 | |
| Total Non-Current Liabilities | 2 | 3 | 3 | 4 | 2 | |
| Total Liabilities | 5 | 6 | 9 | 10 | 4 | |
| Preferred stock, par value $0.0001 per share; 10,000,000 shares authorized at December 31, 2025 and 2024. No shares issued and outstanding | 0 | 0 | 0 | 0 | 0 | |
| Common stock, par value $0.0001 per share; 490,000,000 shares authorized at December 31, 2025 and 2024; 9,766,132 and 2,416,066 shares issued and outstanding at December 31, 2025 and 2024, respectively | 10,000 | 7,000 | 4,000 | 3,000 | 2,000 | |
| Additional paid-in capital | 169 | 136 | 116 | 84 | 71 | |
| Accumulated deficit | −141 | −122 | −91 | −61 | −33 | |
| Total Stockholders' Equity | 28 | 14 | 25 | 23 | −38 | |
| Total Liabilities and Stockholders' Equity | 32 | 21 | 34 | 33 | 42 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −19 | −30 | −30 | −29 | −15 | |
| Depreciation and amortization | 1 | 1 | 1 | 100,000 | 100,000 | |
| Non-cash stock-based compensation | 3 | 5 | 4 | 3 | 2 | |
| Amortization of finance lease right-of-use assets | 771,000 | 859,000 | 871,000 | 461,000 | 537,000 | |
| Amortization of operating lease right-of-use assets | 730,000 | 820,000 | 668,000 | 495,000 | 162,000 | |
| Loss on disposal of construction in progress | 0 | 45,000 | 0 | — | — | |
| Prepaid expenses and other current assets | 670,000 | 2 | 689,000 | −2 | −2 | |
| Other non-current assets | 129,000 | −20,000 | 0 | −97,000 | −159,000 | |
| Accounts payable | −80,000 | −535,000 | −981,000 | 2 | −319,000 | |
| Accrued expenses and other current liabilities | 586,000 | −2 | 796,000 | 924,000 | 554,000 | |
| Short-term operating lease liabilities | 612,000 | 134,000 | 112,000 | 112,000 | 158,000 | |
| Long-term operating lease liabilities | −879,000 | −972,000 | −820,000 | −526,000 | −197,000 | |
| Net cash used in operating activities | −13 | −24 | −23 | −24 | −14 | |
| Purchases of property and equipment | 0 | −104,000 | −405,000 | −4 | 0 | |
| Construction in progress | 0 | −83,000 | −195,000 | −16,000 | −309,000 | |
| Net cash used in investing activities | 0 | −187,000 | −600,000 | −4 | −309,000 | |
| Proceeds from the issuance of common stock, net of issuance costs | 9 | 4 | 14 | 10 | 36 | |
| Principal payments on finance leases | −693,000 | −794,000 | −798,000 | −615,000 | −535,000 | |
| Net cash provided by financing activities | 29 | 14 | 27 | 9 | 33 | |
| Net increase (decrease) in cash and restricted cash | 16 | −10 | 3 | −19 | 19 | |
| Initial measurement of operating lease right-of-use assets and liabilities | 0 | 714,000 | 0 | 3 | 2 | |
| Initial measurement of finance lease right-of-use assets and liabilities | 0 | 564,000 | 536,000 | 1 | 0 | |
| Lease modification of operating lease right-of-use assets and liabilities | −1 | 492,000 | 0 | — | — | |
| Lease modification of finance lease right-of-use assets and liabilities | −1,000 | 0 | 7,000 | 0 | — | |
| Transfer of construction in progress to property and equipment | 0 | 221,000 | 29,000 | 403,000 | 0 |