Aligos Therapeutics, Inc.
Business
Aligos Therapeutics, Inc. is a clinical‑stage biotechnology company developing novel therapeutics to address unmet medical needs in liver diseases and viral infections. Its main product candidates include ALG‑000184 (a capsid assembly modulator for chronic HBV), ALG‑055009 (a THR‑β agonist for MASH), ALG‑097558 (a ritonavir‑free pan‑coronavirus protease inhibitor), siRNA programs such as ALG‑125755, and a portfolio of preclinical candidates. The company operates research and development platforms in small molecules, peptidomimetics and oligonucleotides and pursues collaborations and licensing arrangements. Its programs advance through clinical trials with plans for independent commercialization in select markets and potential partnerships, relying on third‑party contractors for manufacturing and distribution.
Summary from filing dated 2025-03-10
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Revenue from collaborations | 0 | 334,000 | 9 | 14 | 4 | |
| Revenue from customers | 2 | 4 | 6 | — | — | |
| Research and development | 69 | 70 | 73 | 85 | 104 | |
| General and administrative | 21 | 23 | 31 | 26 | 29 | |
| Total operating expenses | 90 | 93 | 104 | 111 | 133 | |
| Loss from operations | −88 | −89 | −88 | −98 | −128 | |
| Interest and other income, net | 4 | 4 | 3 | 2 | 132,000 | |
| Change in fair value of 2023 Common Warrants | 60 | −46 | −2 | — | — | |
| Loss before income tax | −24 | −131 | −87 | −96 | −128 | |
| Income tax provision | −314,000 | −331,000 | −795,000 | −106,000 | −143,000 | |
| Net loss | −24 | −131 | −88 | −96 | −128 | |
| Unrealized gain on available-for-sale securities | 22,000 | 9,000 | 96,000 | −57,000 | — | |
| Unrealized loss on pension plans | −5,000 | −103,000 | 48,000 | 6,000 | 749,000 | |
| Other comprehensive income (loss) | 17,000 | −94,000 | 144,000 | −51,000 | — | |
| Comprehensive loss | −24 | −131 | −88 | −96 | −128 | |
| Net loss per share, basic | −2.45 | −20.94 | −34.2 | −2.25 | — | |
| Net loss per share, diluted | −2.45 | −20.94 | −34.2 | −2.25 | — | |
| Weighted average shares of common stock, basic | 10 | 6 | 3 | 43 | — | |
| Weighted average shares of common stock, diluted | 10 | 6 | 3 | 43 | — |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 18 | 37 | 136 | 81 | 187 | |
| Restricted cash | 100,000 | 100,000 | 100,000 | 100,000 | 200,000 | |
| Short-term investments | 60 | 20 | — | 44 | 4 | |
| Other current assets | 5 | 5 | 5 | 8 | 14 | |
| Total current assets | 83 | 62 | 141 | 134 | 204 | |
| Operating lease right-of-use assets | 3 | 5 | 7 | 8 | 9 | |
| Property and equipment, net | 2 | 2 | 3 | 5 | 6 | |
| Other assets | 715,000 | 627,000 | 625,000 | 634,000 | 866,000 | |
| Total assets | 89 | 70 | 152 | 147 | 235 | |
| Accounts payable | 4 | 3 | 3 | 5 | 3 | |
| Accrued liabilities | 14 | 16 | 17 | 16 | 25 | |
| Operating lease liabilities, current | 4 | 3 | 3 | 3 | 3 | |
| Finance lease liabilities, current | 145,000 | 36,000 | 10,000 | 108,000 | 138,000 | |
| Deferred revenue, current | 0 | 151,000 | 1 | — | — | |
| Total current liabilities | 21 | 22 | 24 | 33 | 39 | |
| Operating lease liabilities, net of current portion | 2 | 5 | 8 | 9 | 11 | |
| Finance lease liabilities, net of current portion | 0 | 122,000 | 231,000 | 230,000 | 261,000 | |
| 2023 Common Warrants liability | 12 | 72 | — | — | — | |
| Long term liability | 47,000 | 46,000 | 46,000 | — | 133,000 | |
| Total liabilities | 35 | 99 | 59 | 43 | 51 | |
| Commitments and contingencies (Note 12) | — | — | — | — | — | |
| Preferred Stock, $0.0001 par value; 10,000,000 shares authorized as of December 31, 2025 and December 31, 2024, respectively; no shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively. | 0 | 0 | — | — | — | |
| Common stock, $0.0001 par value; 115,800,000 shares and 20,800,000 shares authorized as of December 31, 2025 and December 31, 2024, respectively; 6,178,230 and 3,864,436 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively | 9,000 | 8,000 | 7,000 | 4,000 | 4,000 | |
| Additional paid-in capital | 695 | 589 | 578 | 503 | 487 | |
| Accumulated deficit | −642 | −618 | −487 | −399 | −303 | |
| Accumulated other comprehensive income | 468,000 | 451,000 | 545,000 | 401,000 | 452,000 | |
| Total stockholders' equity (deficit) | 54 | −29 | 92 | 104 | 185 | |
| Total liabilities and stockholders' equity (deficit) | 89 | 70 | 152 | 147 | 235 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Accretion of discount on investments | −2 | −2 | −424,000 | −159,000 | 86,000 | |
| Non cash lease expense | 2 | 2 | 2 | 1 | 759,000 | |
| Change in fair value of 2023 Common Warrants | −60 | 46 | 2 | — | — | |
| Depreciation expense | 900,000 | 1 | 2 | 2 | 3 | |
| Stock-based compensation including ESPP | 5 | 8 | 13 | 15 | 13 | |
| Accounts payable | 1 | 54,000 | −2 | 2 | −313,000 | |
| Accrued liabilities | −2 | −1 | 918,000 | −9 | 10 | |
| Operating lease liabilities | −3 | −3 | −2 | −2 | −1 | |
| Deferred revenue | −151,000 | −1 | −8 | 3 | −4 | |
| Other assets | 96,000 | 216,000 | 2 | 6 | −8 | |
| Net cash and cash equivalents used in operating activities | −83 | −81 | −79 | −79 | −116 | |
| Maturities of short-term investments | 128 | 90 | 45 | 79 | 23 | |
| Purchase of short-term investments | −165 | −108 | −11,000 | −104 | −3 | |
| Purchases of property and equipment | −437,000 | −130,000 | — | — | — | |
| Net cash and cash equivalents used in investing activities | −38 | −18 | 45 | −26 | 3 | |
| Proceeds from issuance of common stock upon exercise of pre-funded warrants | — | 2,000 | — | — | — | |
| Proceeds from issuance of common stock, common warrants and pre-funded warrants in connection with PIPE offering, net of costs | 101 | — | — | — | — | |
| Payments on finance lease | −14,000 | −83,000 | −96,000 | −61,000 | −79,000 | |
| Proceeds from the ESPP purchase | 304,000 | 436,000 | 551,000 | 205,000 | — | |
| Net cash and cash equivalents provided by financing activities | 102 | 355,000 | 88 | 164,000 | 79 | |
| Net decrease in cash, cash equivalents, and restricted cash | −19 | −99 | 54 | −106 | −34 |