Sensei Biotherapeutics, Inc.
Business
Sensei Biotherapeutics, Inc. is a clinical-stage biotechnology company developing next-generation, tumor-microenvironment–activated biologics to modulate immune responses in cancer. It offers conditionally active monoclonal and bispecific antibody product candidates, led by solnerstotug (anti‑VISTA), and additional preclinical programs targeting VSIG4, CD39 and a pH‑selective CD28 engager. Its business is organized around its TMAb platform, discovery/preclinical activities and clinical development programs, supported by collaborations and licensing arrangements. Sensei advances candidates through clinical trial networks and relies on contract manufacturing organizations for drug substance and product supply across U.S. and international regulatory markets.
Summary from filing dated 2025-03-28
Financials
Consolidated Statement of Income
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Research and development | 11 | 19 | 18 | 30 | 22 | |
| General and administrative | 11 | 13 | 19 | 20 | 16 | |
| Long-lived asset impairment | 0 | 1 | 0 | — | — | |
| Total operating expenses | 22 | 33 | 37 | 50 | 37 | |
| Loss from operations | −22 | −33 | −37 | −50 | −37 | |
| Interest income | 1 | 3 | 4 | 2 | 800,000 | |
| Interest expense | −32,000 | −90,000 | −144,000 | −219,000 | −670,000 | |
| Other expense, net | −4,000 | −3,000 | −215,000 | 36,000 | −9,000 | |
| Net loss | −21 | −30 | −34 | −49 | −37 | |
| Net loss per common share, basic | −16.72 | −24.01 | −1.22 | −1.58 | −1.33 | |
| Net loss per common share, diluted | −16.72 | −24.01 | −1.22 | −1.58 | −1.33 | |
| Weighted-average number of shares used in computing net loss per common share, basic | 1 | 1 | 28 | 31 | 28 | |
| Weighted-average number of shares used in computing net loss per common share, diluted | 1 | 1 | 28 | 31 | 28 | |
| Net loss attributable to common stockholders | −21 | −30 | −34 | −49 | −37 | |
| Unrealized gain on marketable securities | 14,000 | 196,000 | 795,000 | −671,000 | −333,000 | |
| Total other comprehensive income | 14,000 | 196,000 | 795,000 | −671,000 | −333,000 | |
| Total comprehensive loss | −21 | −30 | −33 | −49 | −37 |
Consolidated Balance Sheet
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Cash and cash equivalents | 9 | 10 | 13 | 18 | 7 | |
| Marketable securities | 13 | 31 | 53 | 89 | 140 | |
| Prepaid expenses | 231,000 | 474,000 | 1 | 1 | 547,000 | |
| Other current assets | 92,000 | 120,000 | 325,000 | 344,000 | 374,000 | |
| Total current assets | 22 | 42 | 67 | 109 | 149 | |
| Right of use assets - operating leases, net | 1 | 3 | 4 | 5 | — | |
| Right of use assets - financing leases, net | 1,000 | 163,000 | 2 | 2 | — | |
| Property and equipment, net | 82,000 | 417,000 | 1 | 2 | 5 | |
| Other non-current assets | 18,000 | 48,000 | 86,000 | 63,000 | 39,000 | |
| Total assets | 23 | 45 | 74 | 118 | 153 | |
| Accounts payable and accrued liabilities | 1 | 1 | 2 | 4 | 2 | |
| Compensation and employee benefits liabilities | 1 | 2 | 2 | 2 | 2 | |
| Operating lease liabilities, current | 1 | 2 | 2 | 1 | — | |
| Financing lease liabilities, current | 80,000 | 732,000 | 872,000 | 880,000 | 680,000 | |
| Total current liabilities | 4 | 5 | 6 | 9 | 5 | |
| Operating lease liabilities, non-current | 59,000 | 1 | 3 | 4 | — | |
| Financing lease liabilities, non-current | 0 | 98,000 | 768,000 | 2 | 2 | |
| Total liabilities | 4 | 7 | 9 | 15 | 7 | |
| Commitments and contingencies (Note 6) | — | — | — | — | — | |
| Preferred stock, $0.0001 par value and 10,000,000 shares authorized as of December 31, 2025 and December 31, 2024; zero shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively | — | — | — | — | — | |
| Common stock, $0.0001 par value and 12,500,000 shares authorized as of December 31, 2025 and December 31, 2024; 1,261,685 and 1,258,940 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively | 0 | 0 | 3,000 | 3,000 | 3,000 | |
| Additional paid-in capital | 302 | 300 | 297 | 302 | 296 | |
| Accumulated deficit | −283 | −262 | −232 | −198 | −149 | |
| Accumulated other comprehensive loss | 1,000 | −13,000 | −209,000 | −1 | −333,000 | |
| Total stockholders' equity | 19 | 38 | 65 | 103 | 147 | |
| Total liabilities and stockholders' equity | 23 | 45 | 74 | 118 | 153 |
Consolidated Statement of Cash Flows
| Concept | Trend | FY 2025 2025-12-31 | FY 2024 2024-12-31 | FY 2023 2023-12-31 | FY 2022 2022-12-31 | FY 2021 2021-12-31 |
|---|---|---|---|---|---|---|
| Net loss | −21 | −30 | −34 | −49 | −37 | |
| Stock-based compensation expense | 1 | 3 | 4 | 6 | 6 | |
| Depreciation and amortization | 100,000 | 600,000 | 600,000 | 600,000 | 685,000 | |
| Accretion on marketable securities | −699,000 | −986,000 | −1 | 231,000 | 615,000 | |
| Impairment of financing right-of-use asset assets | 0 | 600,000 | — | — | — | |
| Impairment of equipment | 0 | 342,000 | — | — | — | |
| Non-cash lease expense | 2 | 2 | 1 | 1 | — | |
| Amortization of financing lease right-of-use assets | 17,000 | 771,000 | 780,000 | 733,000 | — | |
| Prepaid expenses | 243,000 | 694,000 | −99,000 | −582,000 | 828,000 | |
| Other assets | 80,000 | 244,000 | 22,000 | 5,000 | −327,000 | |
| Accounts payable and accrued liabilities | 233,000 | −445,000 | −2 | 2 | −1 | |
| Compensation and employee benefits | −562,000 | 666,000 | −650,000 | 709,000 | 837,000 | |
| Operating lease liabilities | −2 | −2 | −1 | −1 | — | |
| Other liabilities | 0 | −67,000 | 65,000 | −16,000 | 205,000 | |
| Net cash used in operating activities | −20 | −25 | −32 | −39 | −30 | |
| Purchases of property and equipment | −16,000 | −146,000 | −180,000 | −321,000 | −2 | |
| Purchases of short-term investments | −25 | −45 | −21 | −47 | −184 | |
| Maturities of short-term investments | 45 | 67 | 60 | 89 | 31 | |
| Proceeds from sale of property and equipment | 250,000 | 0 | 166,000 | 15,000 | 318,000 | |
| Net cash provided by investing activities | 20 | 22 | 38 | 50 | −143 | |
| Principal payments for financing leases | −790,000 | −811,000 | −761,000 | −629,000 | −255,000 | |
| Proceeds from the sale of financing lease assets | 142,000 | 0 | — | — | — | |
| Payment of employee restricted stock tax withholdings | −3,000 | −10,000 | −76,000 | — | — | |
| Employee stock purchase plan proceeds | 5,000 | 34,000 | 48,000 | 104,000 | 80,000 | |
| Cash in lieu of fractional shares for reverse stock split | −1,000 | 0 | — | — | — | |
| Exercise of options into common stock | 2,000 | 0 | — | 238,000 | 29,000 | |
| Net cash used in financing activities | −645,000 | −787,000 | −11 | −287,000 | 164 | |
| Net decrease in cash and cash equivalents | −1 | −3 | −5 | 11 | −9 | |
| Issuance of equity in exchange for compensation included in compensation and employee benefits | 0 | 293,000 | 302,000 | — | — | |
| Initial measurement of operating lease right-of-use assets | 0 | 28,000 | 331,000 | 7 | — | |
| Initial measurement of operating lease liabilities | 0 | 28,000 | 331,000 | 7 | — | |
| Initial measurement of finance lease right-of-use assets | 0 | 1,000 | — | 704,000 | — |