16.
Segment Information

The Company has one operating segment and one reporting unit. The Company’s chief operating decision maker (“CODM”), its Chief Executive Officer, manages the Company’s operations on a consolidated basis for the purposes of assessing performance and allocating resources. All of the Company’s assets are located in the United States.

The following table summarizes the Company’s segment information for the periods presented (in thousands):

 

 

YEAR ENDED DECEMBER 31,

 

 

 

2025

 

 

2024

 

 

2023

 

Operating expenses(1):

 

 

 

 

 

 

 

 

 

Research and development personnel-related (excluding equity-based compensation)

 

$

68,490

 

 

$

39,013

 

 

$

9,387

 

External research and development costs - zumilokibart (APG777)

 

 

76,441

 

 

 

49,241

 

 

 

21,644

 

External research and development costs - APG990 / APG279

 

 

16,250

 

 

 

20,000

 

 

 

 

External research and development costs - APG333 / APG273

 

 

5,257

 

 

 

28,095

 

 

 

 

External research and development costs - APG808

 

 

3,136

 

 

 

10,311

 

 

 

20,801

 

External-discovery related costs and other

 

 

22,469

 

 

 

11,064

 

 

 

15,019

 

General and administrative personnel-related (excluding equity-based compensation)

 

 

26,740

 

 

 

16,935

 

 

 

8,047

 

General and administrative operations(2)

 

 

19,117

 

 

 

18,690

 

 

 

12,002

 

Equity-based compensation

 

 

46,277

 

 

 

23,332

 

 

 

6,103

 

Depreciation expense

 

 

1,418

 

 

 

189

 

 

 

 

Interest income

 

 

(30,030

)

 

 

(34,742

)

 

 

(9,018

)

Provision for income taxes

 

 

278

 

 

 

18

 

 

 

 

Consolidated net loss

 

$

255,843

 

 

$

182,146

 

 

$

83,985

 

(1)
The significant expense categories and amounts align with the segment-level information that is regularly provided to the CODM
(2)
General and administrative operations are comprised of finance, investor relations, business development, human resources, legal, facilities & IT, and certain other overhead expenses

Historical Timeline

Fiscal YearFiled
2025Mar 2, 2026Showing above
2024Mar 3, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.