Income Taxes
The Company adopted ASU 2023-09 for the year ending December 31, 2025 and added the required disclosures on a prospective basis.
The components of the provision for income taxes are as follows:
Expense classification:Year Ended December 31,
20252024
Current
Federal
$— $(14)
State
— — 
Total
— (14)
Deferred
Federal— — 
State— — 
Total— — 
Provision for Income Tax
$— $(14)
The tax effect of temporary differences between the tax bases of assets and liabilities and their financial reporting amounts that give rise to the deferred tax assets and deferred tax liabilities as of December 31, 2025 and 2024 are as follows:
 December 31,
 20252024
Deferred tax assets:  
Inventory$435 $337 
Accrued expenses178 186 
NOL carryforwards48,764 34,689 
Interest limitation imposed by the TCJA11,392 11,594 
Stock Compensation2,966 6,862 
Deferred Revenue5,144 5,157 
Royalty Monetization16,289 16,117 
Property and Equipment
2,324 2,690 
Orphan Drug and R&D Tax Credits7,528 5,099 
Intangible Assets1,212 137 
Section 174 R&D Capitalization6,906 7,263 
Sales of Royalty Rights
5,055 3,438 
OID and Deferred Financing Cost
2,004 1,636 
Other4,724 143 
114,921 95,348 
Deferred tax liabilities:
Right of use assets(1,161)— 
Prepaid expenses(586)(795)
(1,747)(795)
Valuation Allowance(113,174)(94,553)
Net deferred tax asset/(liability)$— $— 
At December 31, 2025 and 2024, the Company had federal net operating loss carryforwards of $184,246 and $128,658, respectively, which can be carried forward for an indefinite period. At December 31, 2025 and 2024, the Company also had state net operating loss carryforwards of $212,690 and $139,189, respectively, which begin expiring in 2035. At
December 31, 2025 the Company had $7,214 of federal R&D credits and $398 of state R&D credits, which begin expiring in 2037 and 2031, respectively.

The Company has determined, based upon available evidence, that it is more likely than not that the net deferred tax asset will not be realized and accordingly, has provided a full valuation allowance against its net deferred tax assets. Valuation allowances of $113,174, and $94,553 have been established at December 31, 2025 and 2024, respectively. The Company may also be subject to the net operating loss utilization provisions of Section 382 of the Internal Revenue Code due to ownership changes. As a result, the use of NOL carry forwards from the current and prior periods are subject to annual limitations.
On July 4, 2025, the President signed H.R. 1, the Budget Reconciliation Bill, into law. The legislation includes several changes to federal tax law that generally allow for more favorable deductibility of certain business expenses beginning in 2025, including the restoration of immediate expensing of domestic R&D expenditures, reinstatement of 100% bonus depreciation, and more favorable rules for determining the limitation on business interest expense. These changes were reflected in the income tax provision for the year ended December 31, 2025. As the result of the Company maintaining a full valuation allowance against its U.S. federal and state deferred tax assets, the changes introduced by this legislation did not result in a material impact to the Company’s income tax provision or deferred tax balances for the current reporting period. The Company will continue to monitor the potential future impacts of the legislation, including any changes to its valuation allowance assessment, as further guidance becomes available and as facts and circumstances evolve.
The Company has analyzed its tax positions and has concluded that there were no uncertain positions as of December 31, 2025 and 2024.
A reconciliation of income tax expense computed at the statutory federal tax rate to income taxes as reflected in the financial statements is as follows:
 December 31, 2025
 RateTax
At U.S. federal statutory rate21.0 %$(17,595)
Research and development credit2.5 (2,115)
Changes in valuation allowances(18.1)15,174 
Stock compensation(4.7)3,923 
Other items(0.7)613 
Total 0.0 %$— 
 December 31, 2024
Presented under prior guidance
At U.S. federal statutory rate21.0 %
State taxes, net of federal effect3.3 
Permanent differences(1.1)
Tax rate changes(0.7)
Change in valuation allowance(23.5)
FDII deduction
Provison to return adjustments1.0
Effective tax rate0.0 %
During the year ended December 31, 2025, the Company received an ERTC refund of $1,402, which is included in Interest income and other income, net on the Company's Statements of Operations and Comprehensive Loss. The Company also received a refund of $65, including interest, related to the 2023 tax year.

Historical Timeline

Fiscal YearFiled
2025Mar 4, 2026Showing above
2024Mar 5, 2025
2023Mar 5, 2024
2022Mar 31, 2023
2021Mar 8, 2022
2020Mar 9, 2021
2019Mar 11, 2020
2018Mar 14, 2019

About Income Taxes Disclosures

The income tax disclosure reveals how much a company actually pays in taxes versus what the statutory rate would predict. Analysts focus on the effective tax rate (ETR) reconciliation, which breaks down every item driving the gap between the 21% federal rate and the company's reported ETR — including R&D credits, foreign rate differentials, and state taxes. Deferred tax assets (DTAs) and their valuation allowances signal management's confidence in future profitability: a rising allowance suggests the company doubts it can use accumulated tax benefits. Uncertain tax benefit (UTB) reserves quantify exposure to IRS challenges on aggressive positions.

Key signals to watch: sudden ETR drops without clear operational reasons, large increases in valuation allowances, growing UTB balances, and significant unremitted foreign earnings. Post-TCJA, pay attention to GILTI and BEAT provisions that affect multinational tax structures. Compare the cash taxes paid (from the cash flow statement) against the income tax provision to gauge earnings quality.