SEGMENT INFORMATION
The Company operates and is managed as one operating segment which derives revenue from activities related to the development and commercialization of innovative therapies for people with serious and life-threatening rare diseases and medical conditions.
The Company’s commercial organization is responsible for marketing its approved products worldwide. The Company’s R&D organization is responsible for research and discovery of new product candidates and supporting the development and registration efforts for potential new products. The Company’s technical operations group is responsible for the development of
manufacturing processes, supplying clinical drug product, and the manufacturing and distribution of its commercial products. The Company is also supported by corporate staff functions.
The Company’s Chief Executive Officer as the CODM manages and allocates resources to the operations of the total company by assessing the overall level of resources available and how to best allocate them to support the Company’s long-term company-wide strategic goals. In making this decision, the CODM uses consolidated financial information for the purposes of evaluating performance, allocating resources, setting incentive compensation targets and planning and forecasting for future periods.
The key measure of segment profit or loss used by the CODM to allocate resources and assess the Company's performance is its Consolidated Net Income, as reported on the Consolidated Statements of Income. The CODM's analysis includes a comparison to budgeted results. Segment assets provided to the CODM are consistent with those reported on the Consolidated Balance Sheets with particular emphasis on the Company's available liquidity including cash, cash equivalents, investments, accounts receivable and inventory.
The following table includes information about segment revenue, significant segment expenses, and segment measure of profitability:
Years Ended December 31,
202520242023
Total revenues$3,221,253 $2,853,915 $2,419,226 
Less:
Cost of sales717,442 580,235 532,062 
R&D expenses
Research and early pipeline383,705 434,023 393,078 
Later-stage clinical programs308,334 27,581 62,604 
Marketed products229,891 285,580 291,091 
SG&A expenses
S&M expenses
530,156 476,739 488,442 
G&A expenses
622,861 532,286 403,964 
Other segment expense, net (1)
79,963 90,612 80,340 
Net income$348,901 $426,859 $167,645 
(1)Other segment expense, net, during the years ended December 31, 2025, 2024 and 2023 included Intangible Asset Amortization, Interest Income and Expense, Other Income (Expense), Net and Provision for Income Taxes. The year ended December 31, 2024 also included Gain on Sale of Nonfinancial Assets.
The following table presents Total Revenues and disaggregates Net Product Revenues by product.
Years Ended December 31,
202520242023
VOXZOGO$926,923 $735,092 $469,881 
Enzyme Therapies:
VIMIZIM792,051 739,784 701,053 
NAGLAZYME485,400 479,584 420,292 
PALYNZIQ433,310 355,047 303,919 
ALDURAZYME208,508 183,887 131,248 
BRINEURA186,397 169,083 161,889 
KUVAN99,530 120,902 180,767 
ROCTAVIAN35,640 26,066 3,489 
Total net product revenues3,167,759 2,809,445 2,372,538 
Royalty and other revenues53,494 44,470 46,688 
Total revenues$3,221,253 $2,853,915 $2,419,226 
The Company considers there to be revenue concentration risks for regions where Net Product Revenues exceed 10% of consolidated Net Product Revenues. The concentration of the Company’s Net Product Revenues within the regions below may have a material adverse effect on the Company’s revenues and results of operations if sales in the respective regions experience difficulties. The table below disaggregates total Net Product Revenues by geographic region, which is based on patient location for Company's commercial products sold directly by the Company, except for ALDURAZYME, which is distributed, marketed and sold exclusively by Sanofi worldwide.
Years Ended December 31,
202520242023
United States$1,104,973 $924,810 $771,314 
Europe874,331 829,031 669,331 
Latin America435,478 378,084 332,437 
Rest of world544,469 493,633 468,208 
Total net product revenues marketed by the Company2,959,251 2,625,558 2,241,290 
ALDURAZYME net product revenues marketed by Sanofi208,508 183,887 131,248 
Total net product revenues$3,167,759 $2,809,445 $2,372,538 
The following table illustrates the percentage of the Company’s total Net Product Revenues attributed to the Company’s largest customers for the periods presented.
Years Ended December 31,
202520242023
Customer A14 %13 %14 %
Customer B12 %12 %12 %
Customer C11 %10 %10 %
Total37 %35 %36 %
Long-lived assets, which consist of net property, plant and equipment and ROU assets are summarized by geographic region in the following table.
December 31,
20252024
Long-lived assets by geography:
United States$639,669 $755,069 
Ireland331,287 308,123 
Rest of world20,841 13,600 
Total long-lived assets$991,797 $1,076,792 
Concentration Information
On a consolidated basis, two customers accounted for 20% and 10% of the Company’s December 31, 2025 accounts receivable balance, respectively, compared to December 31, 2024 when two customers accounted for 20% and 11% of the accounts receivable balance, respectively. As of December 31, 2025 and 2024, the accounts receivable balance for Sanofi included $148.0 million and $96.8 million, respectively, of unbilled accounts receivable, which becomes payable to the Company when the product is sold through by Sanofi. The Company does not require collateral from its customers, but does perform periodic credit evaluations of its customers’ financial condition and requires prepayments in certain circumstances.
The Company is mindful that conditions in the current macroeconomic environment, such as inflation, changes in interest and foreign currency exchange rates, natural disasters, geopolitical instability, impact of new or increased tariffs and escalating trade tensions, regulatory uncertainty, and supply chain disruptions, could affect the Company’s ability to achieve its goals. In addition, the Company sells its products in countries that face economic volatility and weakness. Although the Company has historically collected receivables from customers in certain countries, sustained weakness or further deterioration of the local economies and currencies may cause customers in those countries to delay payment or be unable to pay for the Company’s products. The Company believes that the allowances for doubtful accounts related to these countries, if any, are adequate based on its analysis of the specific business circumstances and expectations of collection for each of the underlying accounts in these countries. The Company will continue to monitor these conditions and will attempt to adjust its business processes, as appropriate, to mitigate macroeconomic risks to its business.

Historical Timeline

Fiscal YearFiled
2025Feb 26, 2026Showing above
2024Feb 24, 2025
2017Feb 26, 2018
2016Feb 27, 2017
2015Feb 29, 2016

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.