Note 7. Equity-Based Compensation

 

The Company adopted the Cadrenal Therapeutics, Inc. 2022 Equity Incentive Plan (the “Initial Plan”), on July 11, 2022, which was later amended and restated on October 16, 2022, for purposes of clarifying the application of certain of the rules of the Initial Plan to awards approved before such amendment and restatement of the Initial Plan and to facilitate the transition to the Cadrenal Therapeutics, Inc. 2022 Successor Equity Incentive Plan (the “Successor Plan”) for the issuance and approval of awards after consummation of the IPO. On October 16, 2022, the Board adopted and the Company’s stockholders approved the Cadrenal Therapeutics, Inc. 2022 Successor Equity Incentive Plan (the “2022 Plan”), which is a successor to and continuation of the Initial Plan and became effective on January 19, 2023. Upon the effectiveness of the 2022 Plan, it replaced the Initial Plan, except with respect to awards outstanding under the Initial Plan, and no further awards will be available for grant under the Initial Plan.

 

Subject to certain adjustments, the maximum number of shares of common stock that could have been issued under the Initial Plan and 2022 Plan was initially 133,333 shares. The maximum number of shares of common stock that may be issued under the 2022 Plan will automatically increase on January 1 of each calendar year for a period of ten years commencing on January 1, 2024 and ending on (and including) January 1, 2033, to a number of shares of common stock equal to 20% of the total number of shares of common stock outstanding on December 31 of the preceding calendar year; provided, however that the board of directors, or the compensation committee, may act prior to January 1 of a given calendar year to provide that the increase for such year will be a lesser number of shares of common stock. On January 1, 2024, the maximum number of shares of common stock that may be issued under the 2022 Plan increased to 173,636. On July 29, 2024, the Company held its 2024 Annual Meeting of Stockholders (the “2024 Annual Meeting”). At the 2024 Annual Meeting, the Company’s stockholders approved an amendment to the 2022 Plan to increase the number of shares of the Company’s common stock that will be available for awards under the 2022 Plan by 133,333 shares to 306,969 shares and to amend the “evergreen provision” such that the number of reserved shares of common stock available for issuance each year will be 20% of: (i) the shares of common stock outstanding at December 31; plus (ii) the shares of common stock issuable upon exercise of warrants and pre-funded warrants outstanding at December 31. As of December 31, 2025, 67,813 remained available for future issuance. All available shares may be utilized toward the grant of any type of award under the 2022 Plan.

 

Weighted average assumptions used in the Black-Scholes model are set forth below:

 

    Year Ended
December 31,
2025
    Year Ended
December 31,
2024
 
Risk-free interest rate   3.54%  - 4.40%   4.09% - 4.83%
Dividend yield   
-
    
-
 
Expected term (years)   5.27 - 5.89    5.27 - 5.31 
Volatility   73.0% - 75.4%   76.4% - 77.7%

Activity under the Plans for the period from December 31, 2024 to December 31, 2025 is set forth below:

 

   Number
Outstanding
   Weighted-
Average
Exercise
Price Per
Share
   Weighted-
Average
Remaining
Contractual Life
(Years)
   Aggregate
Intrinsic
Value
 
Outstanding at December 31, 2024   156,334   $13.20    8.35   $420,720 
Granted   285,000    19.58    8.45    
-
 
Exercised   (6,667)   9.60    -    
-
 
Canceled/forfeited/expired   (31,667)   17.84    -    
-
 
Outstanding at December 31, 2025   403,000   $17.41    8.51   $299,096 
                     
Options vested and exercisable at December 31, 2025   167,305   $15.45    7.83   $
-
 
Options vested and expected to vest as of December 31, 2025   403,000   $17.41    8.51   $
-
 

 

The weighted average grant date fair value of options granted during the year ended December 31, 2025 was $12.80. At December 31, 2025, the Company had $2.3 million of unrecognized stock-based compensation expense related to stock options which will be recognized over the weighted average remaining requisite service period of 1.9 years. The Company settles employee stock option exercises with newly issued shares of common stock.

  

Total stock-based compensation expense and the allocation of stock-based compensation for the periods presented were as follows:

 

   Years Ended December 31, 
   2025    2024 
         
General and administrative   $1,459,585   $1,030,657 
Research and development    480,311    388,382 
Total equity-based compensation   $1,939,896   $1,419,039 

Historical Timeline

Fiscal YearFiled
2025Mar 31, 2026Showing above
2024Mar 13, 2025
2023Mar 11, 2024
2022Mar 30, 2023

About Stock Compensation Disclosures

Stock-based compensation disclosures detail the equity awards granted to employees and executives — including stock options, restricted stock units (RSUs), and performance shares — along with the valuation methods and assumptions used to expense them. This section reveals the true cost of talent retention and the alignment between management incentives and shareholder interests.

Key signals: total unrecognized compensation expense and its expected recognition period signal future earnings headwinds from already-granted awards. For stock options, examine Black-Scholes assumptions — expected volatility, risk-free rate, and expected term — as understating any of these reduces reported compensation expense. Compare stock compensation expense as a percentage of revenue against peers to assess dilution cost. Watch vesting schedules for acceleration clauses tied to change-of-control events. Performance-based awards with undemanding targets may indicate weak governance. Add back stock compensation to operating cash flow to calculate a more conservative free cash flow figure.