Segments
Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the CODM or decision-making group in making decisions on how to allocate resources and assess performance. The Company’s CODM is its CEO. The CEO views the Company’s operations and manages the Company’s business as one operating segment, which is the business of developing and commercializing genome editing technology.
The Company’s CEO manages and allocates resources to the operations of the Company on a total company basis by assessing the overall level of resources available and how to best deploy these resources across functions and research and development projects that are in line with our long-term company-wide strategic goals. In making these decisions, the Company’s CEO uses consolidated financial information for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. The CODM performs this assessment based on the Company’s consolidated net loss. Through this analysis, the CODM assesses performance by comparing actual
consolidated net loss versus the budget, and then decides how to allocate resources to invest in the Company’s research and development programs. The measure of segment assets is reported on the consolidated balance sheet as total assets.
The following table contains additional information on our consolidated revenue and net loss, including significant segment expenses (in thousands):
Year Ended
December 31,
202420232022
Collaboration and other research and development revenues$32,314 $78,123 $19,712 
Operating expenses:
Research and development1
Employee related expenses61,136 47,363 47,320 
External research and development expenses79,900 53,321 79,822 
Facility expenses26,430 21,447 21,032 
Stock-based compensation expenses8,642 9,842 12,425 
Sublicense and license fees18,953 35,011 5,334 
Other expenses3
12,768 10,667 9,025 
General and administrative2
Employee related expenses24,335 16,969 17,321 
Professional service expenses14,358 19,575 11,496 
Intellectual property and patent related fees14,016 13,268 14,784 
Stock-based compensation expenses12,775 9,956 16,869 
Facility and other expenses4
10,153 9,885 10,234 
Total operating expenses283,466 247,304 245,662 
Operating loss(251,152)(169,181)(225,950)
Other income, net:
Other expense, net(3)(1,604)— 
Interest income, net14,062 17,566 5,518 
Total other income, net14,059 15,962 5,518 
Net loss$(237,093)$(153,219)$(220,432)
1 For the years ended December 31, 2024, 2023, and 2022 includes $8,582, $0, and $0 of restructuring charges, respectively
2 For the years ended December 31, 2024, 2023, and 2022 includes $3,650, $0, and $0 of restructuring charges, respectively
3 Other expenses primarily consists of consultant fees and office expenses
4 Facility and other expenses primarily consists of rent expense, insurance premiums, software licenses and office expenses
For the year ended December 31, 2024, there were two customers for which revenues amount to 10% or more of the Company’s consolidated collaboration and other research and development revenues, representing $18.1 million and $10.0 million of the Company’s consolidated collaboration and other research and development revenues. For the year ended December 31, 2023, there was one customer for which revenues amounts to 10% or more of the Company’s consolidated collaboration and other research and development revenues, representing $60.0 million of the Company’s consolidated collaboration and other research and development revenues. For the years ended December 31, 2024 and 2023, 100% and 100%, respectively, of the Company’s consolidated collaboration and other research and development revenues was attributed to the U.S.

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.