9. Income Taxes

The components of net loss before income taxes consisted of the following (in thousands):

 

 

Year Ended December 31,

 

 

2025

 

 

2024

 

United States

$

(72,485

)

 

$

(30,905

)

International

 

4,147

 

 

 

(4,573

)

Net loss before taxes

$

(68,338

)

 

$

(35,478

)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

The federal and state income tax provision is summarized as follows (in thousands):

 

 

 

Year Ended December 31,

 

 

2025

 

 

2024

 

Current

 

 

 

 

 

   Federal

$

 

 

$

 

   State

 

 

 

 

 

   Foreign

 

1,037

 

 

 

 

Total current tax expense

 

1,037

 

 

 

 

Deferred

 

 

 

 

 

   Federal

 

 

 

 

 

   State

 

 

 

 

 

   Foreign

 

 

 

 

 

Total deferred tax expense

 

 

 

 

 

Total tax expense

$

1,037

 

 

$

-

 

 

The Company adopted ASU 2023-09 “Income Taxes (Topic 740): Improvements To Income Tax Disclosures” on a prospective basis beginning with the year ended December 31, 2025. The following table presents required disclosure pursuant to ASU 2023-09 and reconciles the U.S. federal statutory tax amount and rate to our actual global effective amount and rate for the year ended December 31, 2025:

 

 

 

Year Ended December 31,

 

 

 

2025

 

U.S. federal statutory tax rate

 

$

(14,351

)

 

21.0

%

State and local income taxes, net of federal income tax effect (1)

 

 

 

 

0.0

%

Foreign tax effects

 

 

 

 

 

Other foreign

 

 

166

 

 

-0.2

%

Effect of changes in tax laws or rates enacted in the current period

 

 

 

 

0.0

%

Effects of cross-border tax laws

 

 

 

 

 

   Global intangible low-taxed income

 

 

871

 

 

-1.3

%

Tax credits

 

 

 

 

 

Other

 

 

(294

)

 

0.4

%

Changes in valuation allowance

 

 

14,587

 

 

-21.3

%

Nontaxable or nondeductible items

 

 

 

 

 

Other

 

 

58

 

 

-0.1

%

Changes in unrecognized tax benefits

 

 

 

 

0.0

%

Effective tax rate

 

$

1,037

 

 

-1.50

%

(1) State income taxes in all jurisdictions is zero.

 

 

 

 

 

The following table presents the required disclosures prior to our adoption of ASU 2023-09 and reconciles the U.S. federal statutory income tax rate to the actual global effective income tax rate for the years ended December 31, 2024:

 

 

 

Year Ended December 31,

 

 

 

2024

 

Income tax expense (benefit) at federal statutory rate

 

$

(7,450

)

 

21.0

%

Increase/(decrease) in tax resulting from:

 

 

 

 

 

State income taxes

 

 

 

 

0.0

%

Change in valuation allowance

 

 

6,441

 

 

-18.2

%

Nondeductible R&D Expenses

 

 

921

 

 

-2.6

%

Stock-based compensation expense

 

 

90

 

 

-0.2

%

Other

 

 

(2

)

 

0.0

%

Total

 

$

 

 

0.0

%

 

The primary components of temporary differences which give rise to the Company’s net deferred tax assets and liabilities as of December 31, 2025 and 2024 are as follows (in thousands):

 

 

Year Ended December 31,

 

 

2025

 

 

2024

 

Deferred tax assets:

 

 

 

 

 

Accrual to cash adjustment

$

1,040

 

 

$

499

 

Start-up costs

 

9,101

 

 

 

7,190

 

Patent costs

 

40

 

 

 

40

 

Stock-based compensation expense

 

1,937

 

 

 

1,432

 

Net operating loss

 

13,378

 

 

 

7,638

 

Capitalized R&D

 

12,619

 

 

 

6,813

 

Other deferred taxes

 

34

 

 

 

21

 

R&D credits

 

1,336

 

 

 

868

 

Total noncurrent deferred tax assets

 

39,485

 

 

 

24,501

 

Valuation allowance

 

(39,485

)

 

 

(24,501

)

Net deferred tax assets after valuation allowance

$

 

 

$

 

 

 

In July 2025, the One Big Beautiful Bill Act (“OBBBA”) modified the Section 174 capitalization rules. Under the OBBBA provisions, the Company discontinued capitalization of domestic Section 174 costs beginning in tax year 2025, while continuing to capitalize foreign Section 174 costs. As a result, deferred tax assets related to capitalized research expenditures increased by $5.8 million during the year ended December 31, 2025.

 

The Company has evaluated the positive and negative evidence bearing upon the realizability of its deferred tax assets. Based upon the Company’s history of operating losses, the Company has concluded that it is more likely than not that the benefit of its deferred tax assets will not be realized. Accordingly, the Company has provided a full valuation allowance for deferred tax assets as of December 31, 2025 and 2024. During 2025 and 2024, the valuation allowance increased by $15.0 million and $5.9 million, respectively.

 

As of December 31, 2025, the Company has federal and California research and development tax credit carryforwards of $1.2 million and $0.9 million, respectively. The federal research and development tax credits begin to expire in 2041 unless previously utilized. The California credits do not expire.

 

Net operating losses and tax credit carryforwards as of December 31, 2025 are as follows (in thousands):

 

 

 

Amount

 

 

Expiration Years

Net operating losses, federal (Post December 31, 2017)

 

$

59,836

 

 

Do Not Expire

Net operating losses, federal (Pre January 1, 2018)

 

$

11

 

 

2037

Net operating losses, state

 

$

11,602

 

 

2037

Net operating losses, foreign

 

$

 

 

Indefinite

Tax credits, federal

 

$

1,172

 

 

2041

Tax credits, state

 

$

933

 

 

Indefinite

 

The Company is subject to taxation in the U.S., Australia and California. As of December 31, 2025, Tocagen’s tax years beginning 2007 to date are subject to examination by federal and California taxing authorities due to the carry forward of unutilized net operating losses and research and development tax credits. To the extent the Company has tax attribute carryforwards, the tax years in which the attribute was generated may still be adjusted upon examination by the Internal Revenue Service or state tax authorities to the extent utilized in a future period.

 

Pursuant to Internal Revenue Code (IRC) Sections 382 and 383, annual use of a company’s net operating loss and tax credit carryforwards may be limited if there is a cumulative change in ownership of greater than 50% (by value) within a three-year period. The amount of the annual limitation is determined based on the value of the Company immediately prior to the ownership change. Subsequent ownership changes may further affect the limitation in future years. The Company has completed several equity offerings since its inception which may have resulted in a change in control as defined by Sections 382 and 383 of the IRC, or could result in a change in control in the future. The Company has not completed an IRC Section 382 and 383 analysis regarding the limitation of net operating loss and research and development credit carryforwards. Upon completion of such an analysis, there may be either increases

or decreases to the reported amount of the deferred tax assets for net operating losses and federal and California research and development credits. Any change in the amount of the deferred tax assets would have a corresponding change in the valuation allowance, and therefore is not expected to impact the Company’s effective tax rate.

 

The Company recognizes a tax benefit from an uncertain tax position when it is more likely than not that the position will be sustained upon examination, including resolutions of any appeals or litigation processes. Income tax positions must meet a more likely than not recognition at the effective date to be recognized.

 

A reconciliation of the beginning and ending amount of unrecognized tax benefits for 2025 and 2024 is as following (in thousands):

 

 

Year Ended December 31,

 

 

2025

 

 

2024

 

Beginning Balance

$

411

 

 

$

251

 

Additions based on tax positions related to the current year

$

221

 

 

$

160

 

Ending Balance

$

632

 

 

$

411

 

 

The Company’s policy is to record interest and penalties relating to uncertain tax positions as a component of income tax expense should the Company believe there is an uncertain tax position liability. As of December 31, 2025, and 2024, there was no accrued interest or penalties for uncertain positions.

Historical Timeline

Fiscal YearFiled
2025Mar 31, 2026Showing above
2024Mar 28, 2025
2023Mar 18, 2024
2022Mar 31, 2023
2021Mar 31, 2022
2020Mar 16, 2021
2019Feb 27, 2020
2018Feb 27, 2019
2017Mar 9, 2018

About Income Taxes Disclosures

The income tax disclosure reveals how much a company actually pays in taxes versus what the statutory rate would predict. Analysts focus on the effective tax rate (ETR) reconciliation, which breaks down every item driving the gap between the 21% federal rate and the company's reported ETR — including R&D credits, foreign rate differentials, and state taxes. Deferred tax assets (DTAs) and their valuation allowances signal management's confidence in future profitability: a rising allowance suggests the company doubts it can use accumulated tax benefits. Uncertain tax benefit (UTB) reserves quantify exposure to IRS challenges on aggressive positions.

Key signals to watch: sudden ETR drops without clear operational reasons, large increases in valuation allowances, growing UTB balances, and significant unremitted foreign earnings. Post-TCJA, pay attention to GILTI and BEAT provisions that affect multinational tax structures. Compare the cash taxes paid (from the cash flow statement) against the income tax provision to gauge earnings quality.