14. Segment Reporting

Our CODM manages our operations on an integrated basis for the purpose of allocating resources. When evaluating our financial performance, the CODM regularly reviews total revenues, total expenses, and research and development expenses by project and the CODM makes decisions using this information.

The table below is a summary of the segment profit or loss, including significant expenses, in thousands:

 

 

Years Ended December 31,

 

 

2025

 

 

2024

 

 

2023

 

Revenue

 

 

 

 

 

 

 

 

Product revenue, net

$

2,132

 

 

$

 

 

$

 

Collaboration revenue

 

65,350

 

 

 

53,883

 

 

 

 

Total revenue

 

67,482

 

 

 

53,883

 

 

 

 

Less:

 

 

 

 

 

 

 

 

Cost of product sales

 

57

 

 

 

 

 

 

 

Ziftomenib-related costs

 

142,579

 

 

 

79,338

 

 

 

35,933

 

Darlifarnib-related costs

 

26,714

 

 

 

18,829

 

 

 

10,629

 

Tipifarnib-related costs

 

3,490

 

 

 

4,770

 

 

 

12,190

 

Discovery stage program-related costs

 

7,230

 

 

 

6,621

 

 

 

5,399

 

Research and development personnel costs and other expenses

 

58,474

 

 

 

45,789

 

 

 

38,424

 

Share-based compensation expense

 

37,108

 

 

 

33,897

 

 

 

28,082

 

Other segment expenses(1)

 

95,461

 

 

 

57,834

 

 

 

35,147

 

Total operating expenses

 

371,113

 

 

 

247,078

 

 

 

165,804

 

Other income (expenses)

 

 

 

 

 

 

 

 

Interest and other income, net

 

26,774

 

 

 

22,849

 

 

 

14,722

 

Interest expense

 

(1,512

)

 

 

(1,619

)

 

 

(1,549

)

Income tax expense

 

(297

)

 

 

(2,018

)

 

 

 

Segment and net loss

$

(278,666

)

 

$

(173,983

)

 

$

(152,631

)

 

(1)
Other segment expenses are comprised of selling, general and administrative expenses, excluding share-based compensation expense, which is shown separately.

Historical Timeline

Fiscal YearFiled
2025Mar 5, 2026Showing above
2024Feb 28, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.