Segment Reporting
The Company operates and manages its business as one operating segment, which primarily focuses on developing novel small molecule therapeutics to treat unmet medical needs in immune-mediated diseases. The Company’s Chief Executive Officer serves as the Company’s Chief Operating Decision Maker (CODM), who reviews consolidated financial information on a company-wide basis for purposes of allocating resources and assessing financial performance. The measure of segment assets is reported on the consolidated balance sheets as total assets. The following table represents selected financial information for our segment for the years ended December 31, 2025, 2024 and 2023, in thousands:
Year Ended December 31,
202520242023
Collaboration revenue$— $— $7,000 
Internal costs
Total salary / benefits21,800 21,228 30,105 
External costs by program
Zetomipzomib15,855 36,652 40,513 
KZR-261839 5,940 6,428 
Other protein secretion discovery programs33 289 5,604 
General and administrative9,523 10,888 13,663 
Other segment items (1)11,057 15,608 22,111 
Total operating expenses$59,107 $90,605 $118,424 
Loss from operations(59,107)(90,605)(111,424)
Interest income4,444 8,462 11,104 
Other expenses(1,370)(1,593)(1,550)
Consolidated segment net loss$(56,033)$(83,736)$(101,870)
(1) Other segment items include stock-based compensation expense, depreciation and amortization, loss on disposal of property and equipment, impairment loss of property and equipment, and in 2024 and 2023, impairment loss of right-of-use asset.

Historical Timeline

Fiscal YearFiled
2025Mar 27, 2026Showing above
2024Mar 25, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.