15. Segment Information

We operate as a single business segment focused on revolutionizing care for patients with challenging respiratory and vascular diseases such as PAH and PH-ILD. The determination of a single business segment is consistent with the consolidated financial information regularly reviewed by our Chief Executive Officer, the chief operating decision maker (“CODM”), in assessing segment performance and deciding how to allocate resources on a consolidated basis. The accounting policies of the segment are the same as those described in the summary of significant accounting policies.

The CODM measures segment profit and loss by net loss as reported in the consolidated income statements. The CODM uses net loss to monitor budget and forecast versus actual results to assess segment performance and to allocate resources across the organization. The measure of segment assets is reported on the consolidated balance sheet as total assets.

The following table summarizes segment revenue, segment loss, and significant segment expenses regularly reported to the CODM during the years ended December 31, 2025, 2024 and 2023:

Year Ended December 31, 

2025

2024

2023

Revenues:

Product sales, net

$

148,288

$

$

Service revenue, net

10,032

13,996

17,488

Total revenue

158,320

13,996

17,488

Cost of product sales

8,824

Cost of service revenue

4,418

5,879

2,888

Program expenses (1)

YUTREPIA

55,441

37,352

23,487

L606

19,678

12,052

12,551

Generic Treprostinil

364

720

308

Total program expenses

75,483

50,124

36,346

Non-program expenses (2)

 

21,967

 

15,530

 

12,854

Personnel, including stock-based compensation

99,004

63,757

38,784

Income (loss) from operations

 

(51,376)

 

(121,294)

 

(73,384)

Other income (expense), net

 

(17,548)

 

(6,997)

 

(5,118)

Net loss

$

(68,924)

$

(128,291)

$

(78,502)

(1)Includes external research and development and selling, general and administrative expenses
(2)Includes professional service fees, facilities & infrastructure expenses, insurance, depreciation & amortization, and other corporate expenses

Historical Timeline

Fiscal YearFiled
2025Mar 5, 2026Showing above
2024Mar 19, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.