Segments
The Company defines its segments on the basis of the way in which internally reported financial information is regularly reviewed by the CODM to analyze financial performance, make decisions, and allocate resources. The Company’s CODM is the Chief Executive Officer. The Company manages its operations as a single operating and reportable segment and the measure of segment profit or loss is net loss. The CODM uses net loss in the budget and forecasting process and considers budget-to-actual variances on a quarterly basis when making decisions about the allocation of operating and capital resources. The following table summarizes the significant segment expenses presented on the Company's consolidated statements of operations and comprehensive loss:
Year Ended December 31,
(in thousands)20252024
Direct research and development by program
VDPHL01
55,831 14,641 
VDMN1,101 3,747 
VDMC36 1,329 
VDAA402 
Other program candidates and expenses
48 1,370 
Other unallocated research and development costs
Personnel expenses (including share-based compensation)4,633 1,499 
Other expenses
407 295 
General and administrative, excluding personnel expenses
7,243 2,319 
General and administrative, personnel expenses (including share-based compensation)
3,039 1,176 
Other segment items(1)
(2,352)(290)
Segment net loss
(69,995)(26,488)
(1)For the year ended December 31, 2025 other segment items include interest income of $1.6 million and investment accretion of $0.8 million. For the year ended December 31, 2024, other segment items include interest income of $0.5 million and research and development tax credit of $0.4 million, partially offset by $0.6 million of interest expense.
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About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.