6.
Revenue

The following table disaggregates total revenues from external customers by product sales, royalty revenue, and collaboration and license revenue (in millions):

 

Year Ended December 31,

 

 

2025

 

 

2024

 

 

2023

 

Product sales:

 

 

 

 

 

 

 

 

Crysvita

$

177

 

 

$

135

 

 

$

75

 

Dojolvi

 

96

 

 

 

88

 

 

 

71

 

Evkeeza

 

59

 

 

 

32

 

 

 

4

 

Mepsevii

 

37

 

 

 

30

 

 

 

30

 

Total product sales

 

369

 

 

 

285

 

 

 

180

 

Crysvita royalty revenue

 

304

 

 

 

275

 

 

 

183

 

Collaboration and license revenue:

 

 

 

 

 

 

 

 

Crysvita collaboration revenue in Profit-Share Territory

 

 

 

 

 

 

 

70

 

Other

 

 

 

 

 

 

 

1

 

Total collaboration and license revenue

 

 

 

 

 

 

 

71

 

Total revenues

$

673

 

 

$

560

 

 

$

434

 

The following table disaggregates total revenues based on geographic location (in millions):

 

Year Ended December 31,

 

 

2025

 

 

2024

 

 

2023

 

North America

$

377

 

 

$

340

 

 

$

307

 

Latin America

 

170

 

 

 

131

 

 

 

77

 

Europe, Middle East, and Africa

 

108

 

 

 

80

 

 

 

48

 

Asia-Pacific

 

18

 

 

 

9

 

 

 

2

 

Total revenues

$

673

 

 

$

560

 

 

$

434

 

The following table presents the activity and ending balances for product sales related accruals and allowances (in millions):

 

Year Ended December 31,

 

 

2025

 

 

2024

 

 

2023

 

Balance of product sales reserve at beginning of year

$

33

 

 

$

17

 

 

$

11

 

Provisions

 

50

 

 

 

38

 

 

 

19

 

Payments

 

(30

)

 

 

(21

)

 

 

(13

)

Adjustments

 

4

 

 

 

(1

)

 

 

 

Balance of product sales reserve at end of year

$

57

 

 

$

33

 

 

$

17

 

The Company’s largest accounts receivable balance was from a collaboration partner, KKC, and was 62% and 70% of the total accounts receivable balance as of December 31, 2025 and 2024, respectively.

Historical Timeline

Fiscal YearFiled
2025Feb 18, 2026Showing above
2024Feb 19, 2025
2023Feb 21, 2024
2022Feb 17, 2023
2021Feb 15, 2022
2020Feb 12, 2021
2019Feb 14, 2020
2018Feb 20, 2019

About Revenue Disclosures

Revenue disclosures under ASC 606 explain how a company identifies performance obligations, allocates transaction prices, and determines when revenue is recognized. This section is essential for understanding whether reported revenue reflects genuine economic activity or aggressive accounting choices. Analysts examine the mix of point-in-time versus over-time recognition, which directly affects revenue timing and comparability.

Key signals: rising contract liabilities (deferred revenue) suggest strong future revenue visibility, while declining contract assets may indicate slowing project milestones. Watch for variable consideration estimates — rebates, returns, and performance bonuses that require management judgment. Significant changes in disaggregated revenue by geography or product line can reveal shifting business mix before it appears in headline numbers. Compare revenue growth against contract liability growth to assess sustainability, and scrutinize any changes in the timing of recognition that coincide with earnings pressure.