SEGMENTS
The Company defines its segments on the basis of the way in which internally reported financial information is regularly reviewed by the CODM to analyze financial performance, make decisions, and allocate resources. The Company’s CODM consists of its Chief Executive Officer, Chief Financial Officer and Chief Medical Officer. The Company manages its operations as a single operating and reportable segment and the measure of segment profit or loss is net loss and comprehensive loss. The CODM uses net loss in the budget and forecasting process and considers budget-to-actual variances on a quarterly basis when making decisions about the allocation of operating and capital resources.
The following table summarizes the information about reported segment revenues and significant segment expenses presented on the Company's consolidated statements of operations and comprehensive loss:
FOR THE YEAR ENDED
DECEMBER 31,
(in thousands)20242023
Revenue$636 $— 
Less:
  Research and development:
RLYB21221,287 25,685 
RLYB1164,841 8,791 
Other program candidates1,901 3,411 
Personnel expenses (including share-based compensation)12,488 14,160 
Other expenses990 1,497 
    Total research and development41,507 53,544 
General and administrative, excluding personnel expenses6,654 10,313 
General and administrative, personnel expenses (including share-based compensation)12,971 15,075 
Other segment items*(2,721)(4,368)
Segment net loss$(57,775)$(74,564)
*Other segment items includes total other income, net and loss on investment in joint venture.

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.