12. Income Taxes

The components of loss before income taxes for the years ended December 31, 2025 and 2024 are as follows (in thousands):

 

 

 

December 31,

 

 

 

2025

 

 

2024

 

Domestic

 

$

(84,300

)

 

$

(63,256

)

Foreign

 

 

(34,537

)

 

 

(32,625

)

Total

 

$

(118,837

)

 

$

(95,881

)

 

The Company did not record a federal tax benefit or expense for the years ended December 31, 2025 and 2024. The Company recorded a minimal state provision for income taxes for the year ended December 31, 2024 and no state provision for income taxes for the year ended December 31, 2025 due to revenues below the minimum tax threshold. The components of the income tax expense are as follows for the years ended December 31, 2025 and 2024 (in thousands):

 

 

 

December 31,

 

 

 

2025

 

 

2024

 

Current:

 

 

 

 

 

 

Federal

 

$

 

 

$

 

State

 

 

 

 

 

9

 

Foreign

 

 

 

 

 

 

Total Current

 

 

 

 

 

9

 

Deferred:

 

 

 

 

 

 

Federal

 

 

 

 

 

 

State

 

 

 

 

 

 

Foreign

 

 

 

 

 

 

Total Deferred

 

 

 

 

 

 

Total income tax expense

 

$

 

 

$

9

 

 

As noted above, we adopted ASU 2023-09 on a prospective basis effective January 1, 2025. The following table presents required disclosure pursuant to ASU 2023-09 and reconciles the U.S. federal statutory tax amount and rate to our actual global effective amount and rate for the year ended December 31, 2025:

 

 

 

December 31, 2025

 

 

 

 

 

 

 

 

Federal

 

$

(24,956

)

 

 

21.00

%

Other States

 

 

 

 

 

0.00

%

Foreign

 

 

 

 

 

 

Income taxes, net of amounts refunded

 

 

 

 

 

 

Statutory tax rate difference between DK and US

 

 

(345

)

 

 

0.29

%

Change in valuation allowance

 

 

6,968

 

 

 

-5.86

%

Other

 

 

630

 

 

 

-0.53

%

Tax credits

 

 

 

 

 

 

Orphan drug tax credit

 

 

(8,033

)

 

 

6.76

%

Change in valuation allowance

 

 

23,375

 

 

 

-19.67

%

Nontaxable or Nondeductible Items

 

 

 

 

 

 

Imputed Interest Income

 

 

1,810

 

 

 

-1.52

%

162(m) Limitation

 

 

1,150

 

 

 

-0.97

%

Other

 

 

(604

)

 

 

0.50

%

Other adjustments

 

 

 

 

 

 

Other

 

 

5

 

 

 

0.00

%

Total

 

$

 

 

 

0.00

%

 

(a)
The company does not have any state income tax in current year.

A reconciliation of the expected income tax results computed using the federal statutory income tax rate to the Company’s effective income tax rate is as follows for the year ended December 31, 2024 (in thousands):

 

 

 

December 31, 2024

 

Income tax benefit computed at federal statutory tax rate

 

$

(20,135

)

State taxes, net of federal

 

 

7

 

Change in valuation allowance

 

 

29,911

 

Orphan drug & research credits generated

 

 

(9,659

)

Impact of foreign operations

 

 

(338

)

Foreign deferred tax asset - true up

 

 

(750

)

Actualization and deferred tax asset - true up

 

 

(214

)

Imputed interest

 

 

1,498

 

Permanent differences

 

 

(311

)

Other

 

 

 

Total

 

$

9

 

 

Deferred income taxes reflect the net tax effects of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. The Company has established a valuation allowance due to uncertainties regarding the realization of deferred tax assets based upon the Company’s lack of earnings history. During the years ended December 31, 2025 and 2024, the valuation allowance increased by $35.4 million and $33.5 million, respectively.

Significant components of the Company’s deferred tax assets and liabilities are as follows (in thousands):

 

 

 

December 31,

 

 

 

2025

 

 

2024

 

Deferred tax liabilities:

 

 

 

 

 

 

ROU assets

 

$

23

 

 

$

67

 

Other

 

 

397

 

 

 

687

 

Total deferred tax liabilities

 

 

420

 

 

 

754

 

Deferred tax assets:

 

 

 

 

 

 

Net operating loss carryforwards

 

 

85,643

 

 

 

58,384

 

Intangible assets

 

 

111

 

 

 

379

 

Amortization

 

 

 

 

 

1,263

 

Credit carryforwards

 

 

30,656

 

 

 

22,624

 

Section 174 research and development expenses

 

 

20,007

 

 

 

20,058

 

ROU liabilities

 

 

2

 

 

 

56

 

Depreciation

 

 

315

 

 

 

272

 

Stock-based compensation

 

 

4,448

 

 

 

3,618

 

Accrued liabilities & other

 

 

1,969

 

 

 

1,456

 

Total deferred tax assets

 

 

143,151

 

 

 

108,110

 

Subtotal

 

 

142,731

 

 

 

107,356

 

Valuation allowance

 

 

(142,731

)

 

 

(107,356

)

Net deferred taxes

 

$

 

 

$

 

 

The Company completed a Section 382 analysis to determine the amount of losses that are currently available for potential offset against future taxable income. Based on the analysis, it was determined that the utilization of the Company's NOLs and tax credit carryforwards generated in tax periods up to and including December 2019 are substantially limited and may result in the expiration of such carryforwards prior to utilization. In general, an ownership change, as defined by Section 382, results from transactions that increase the ownership of 5% shareholders in the stock of a corporation by more than 50 percentage points in the aggregate over a three-year period. Since the Company's formation, it has raised capital through public and private issuance of common stock on several occasions which have ultimately resulted in multiple changes in ownership, as defined by Section 382. As of December 31, 2025 and 2024, the Company still has $53.9 million of federal Section 382 NOLs, collectively, which are included in the federal NOL carryforwards below, that are severely limited in future years.

As of December 31, 2025 and 2024, the Company had foreign NOL carryforwards of approximately $177.1 million and $137.7 million, respectively, which have an indefinite carryforward period. After taking the Section 382 limitations discussed into account, as of December 31, 2025 and 2024, the Company had NOLs for federal income tax purposes of approximately $195.3 million and $126.0 million, respectively. Federal NOL carryforwards of $5.2 million begin to expire in 2037, with $190.1 million not having an expiration date. As of December 31, 2025 and 2024, the Company had state NOL carryforwards of approximately $96.0 million and $25.3 million, respectively. The state NOL carryforwards begin to expire in 2037.

As of December 31, 2025 and 2024, the Company also had available research and orphan drug tax credit carryforwards for federal income tax purposes of approximately $30.2 million and $22.1 million, respectively. If not utilized, these carryforwards expire at various dates beginning in 2039. As of December 31, 2025 and 2024, the Company had state research and development tax credit carryforwards of approximately $0.5 million and $0.5 million, respectively, which will begin to expire in 2034 if not utilized.

Law Changes

On July 4, 2025, H.R. 1 – OBBBA, the One Big Beautiful Bill Act (“OBBBA”), was signed into law. Effective beginning in 2025, OBBBA provides for US tax law changes and modifications including the ability to deduct US based research and development expenditures, a more favorable interest expense limitation, the reinstatement of 100% bonus depreciation on qualified property and several changes to the US taxation of foreign activity. Given the Company’s history of net operating losses, OBBBA did not have a significant impact on the Company’s financial statements.

 

The Company applies the accounting guidance in ASC 740 Income Taxes related to accounting for uncertainty in income taxes. The Company’s reserves related to taxes are based on a determination of whether, and how much of, a tax benefit taken by the Company in its tax filings or positions is more likely than not to be realized following resolution of any potential contingencies present related to the tax benefit. As of December 31, 2025 and 2024, the Company had no unrecognized tax benefits. During the years ended December 31, 2025 and 2024, the Company had no interest and penalties related to income taxes.

The Company files income tax returns in the U.S. federal, state, and foreign jurisdictions. As of December 31, 2025, the statute of limitations for assessment by the Internal Revenue Service (“IRS”) is open for the 2020 and subsequent tax years, although carryforward attributes that were generated for tax years prior to then may still be adjusted upon examination by the IRS if they either have been, or will be, used in a future period. The 2020 and subsequent tax years remain open and subject to examination by the state taxing authorities. The 2021 and subsequent tax years remain open and subject to examination by the foreign taxing authorities. There are currently no federal, state, or foreign income tax audits in progress.

New Accounting Pronouncement Adoption

We adopted ASU 2023-09 on a prospective basis for the year ended December 31, 2025 and have included the following table as a result of our adoption, which presents income taxes paid (net of refunds received) for the year ended December 31, 2025:

 

 

 

December 31, 2025

 

 

 

 

 

Federal

 

$

 

Other States

 

 

 

Foreign

 

 

 

Income taxes, net amounts refunded

 

$

 

Historical Timeline

Fiscal YearFiled
2025Mar 13, 2026Showing above
2024Mar 27, 2025
2023Mar 7, 2024
2022Mar 30, 2023
2021Mar 30, 2022
2020Mar 10, 2021
2019Mar 12, 2020
2018Mar 13, 2019
2017Mar 14, 2018
2016Mar 6, 2017
2015Mar 14, 2016

About Income Taxes Disclosures

The income tax disclosure reveals how much a company actually pays in taxes versus what the statutory rate would predict. Analysts focus on the effective tax rate (ETR) reconciliation, which breaks down every item driving the gap between the 21% federal rate and the company's reported ETR — including R&D credits, foreign rate differentials, and state taxes. Deferred tax assets (DTAs) and their valuation allowances signal management's confidence in future profitability: a rising allowance suggests the company doubts it can use accumulated tax benefits. Uncertain tax benefit (UTB) reserves quantify exposure to IRS challenges on aggressive positions.

Key signals to watch: sudden ETR drops without clear operational reasons, large increases in valuation allowances, growing UTB balances, and significant unremitted foreign earnings. Post-TCJA, pay attention to GILTI and BEAT provisions that affect multinational tax structures. Compare the cash taxes paid (from the cash flow statement) against the income tax provision to gauge earnings quality.