16. Segment Information

The Company’s CODM, the Company’s Chief Executive Officer, views the Company’s operations and manages its business as a single operating segment, which is the business of developing and commercializing genetic medicine. The Company therefore has one reportable segment.

The CODM reviews the segment's profit or loss based on net (loss) income reported on the consolidated statement of operations and comprehensive (loss) income and considers forecast-to-actual variances monthly for expenses that are deemed significant in making resource allocation decisions and assessing performance. Further, the CODM reviews the segment's assets based on total assets reported on the consolidated balance sheets. All long-lived assets are held in the United States.

The CODM views specific categories within research and development expenses and general and administrative expenses in totality as significant. Further, the CODM reviews the external research and development expenses of specific programs as significant given the impact on achieving the Company’s corporate goals. The following table reconciles reported collaboration revenue to net (loss) income under the significant expense principle for the years ended December 31, 2025, 2024, and 2023:

Year ended December 31, 

2025

  ​ ​ ​

2024

  ​ ​ ​

2023

Collaboration revenue

  ​ ​ ​

$

40,374

  ​ ​ ​

$

80,001

  ​ ​ ​

$

250,008

External research and development (1):

Anti-tau antibody program (VY7523)

20,069

15,647

16,923

SOD1 silencing gene therapy program

2,267

15,818

6,251

Tau silencing gene therapy program (VY1706)

19,188

7,455

696

Partnered programs (2)

5,495

4,985

7,650

Other programs and platforms (3)

17,332

14,176

14,488

Internal research and development (4)

42,106

38,422

27,860

Facilities and other research and development (5)

28,217

30,865

18,304

General and administrative (5)

37,544

35,920

35,822

Interest income

10,618

18,328

11,721

Other income

1,649

622

3

Income tax provision

144

665

1,408

Net (loss) income

$

(119,721)

$

(65,002)

$

132,330

(1)External research and development is allocated to the Company’s programs and platforms, and includes laboratory supplies, and non-employee consultant and contractor costs.
(2)Partnered programs include programs in which the Company is collaborating with partners to develop AAV gene therapy products and product candidates under the Company’s 2019 and 2023 Neurocrine Collaboration Agreements, and the 2023 Novartis Collaboration Agreement.
(3)Other programs and platforms consist of expenses related to other early research programs and platforms which are not considered quantitatively and qualitatively significant, including capsid discovery, non-viral delivery, and early research programs.
(4)Internal research and development consist of employee-related expenses including salaries, benefits, and stock-based compensation expense.
(5)Depreciation and amortization expense is allocated between general and administrative and facilities and other research and development.

Historical Timeline

Fiscal YearFiled
2025Mar 9, 2026Showing above
2024Mar 11, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.