9. Income Taxes

During the years ended December 31, 2025 and 2024, the Company did not record an income tax benefit for net operating losses incurred in each year due to the uncertainty of realizing a benefit from those items.    

Loss before income taxes is allocated as follows:

Year Ended December 31,

(In thousands)

2025

2024

U.S. operations

$

(64,923)

$

(132,065)

Foreign operations

Loss before income taxes

$

(64,923)

$

(132,065)

A reconciliation of the provision for income taxes to the amount computed by applying the 21% U.S. federal statutory income tax rate to income before income taxes after the adoption of ASU 2023-09 is as follows:

(In thousands, except percentages)

Year Ended December 31, 2025

Federal taxes at U.S. statutory income tax rate

  ​ ​ ​

$

(13,634)

(21.0)

%

Tax credits

Research and development tax credits

(2,531)

(3.9)

 

Change in valuation allowance

14,366

22.1

Non-taxable or non-deductible items

Non-deductible royalty payments

726

1.1

Other non-deductible items

1,073

1.7

Effective income tax rate

$

0.0

%

A reconciliation of the provision for income taxes to the amount computed by applying the 21% U.S. federal statutory income tax rate to income before income taxes for years prior to the adoption of ASU 2023-09 is as follows:

Year Ended December 31, 2024

Federal statutory income tax rate

  ​ ​ ​

(21.0)

%

State taxes, net of federal benefit

(2.1)

 

Impact of state rate changes

(1.1)

Research and development tax credits

(1.1)

 

Excess equity compensation tax benefit, net of officer limitation

0.8

Revaluation of contingent consideration

0.4

Non-deductible royalty payments

1.8

Change in deferred tax asset valuation allowance

22.1

Other

0.2

Effective income tax rate

(0.0)

%

Deferred tax liabilities, net consisted of the following:

December 31,

(In thousands)

2025

2024

Deferred tax assets:

  ​ ​ ​

  ​ ​ ​

  ​ ​ ​

  ​ ​ ​

Net operating loss carryforwards

$

123,685

$

120,361

Capitalized start-up costs

2,949

3,469

Research and development tax credit carryforwards

 

2,531

 

21,954

Section 174 research and development capitalization

21,396

31,185

Capitalized research and development expense

 

1,820

 

2,145

Stock‑based compensation expense

 

20,093

 

19,101

Accrued compensation

796

791

Lease liabilities

474

588

Deferred income

4,536

5,510

IPR&D

19,534

20,004

Other

 

397

 

408

Total deferred tax assets

 

198,211

 

225,516

Deferred tax liabilities:

Property and equipment

(31)

(56)

Right-to-use assets

(510)

(642)

Other

 

(559)

 

(458)

Total deferred tax liabilities

 

(1,100)

 

(1,156)

Valuation allowance

 

(197,111)

 

(224,360)

Deferred tax liabilities, net

$

$

As of December 31, 2025, the Company had federal and state net operating loss (“NOL”) carryforwards of $568.2 million and $100.7 million, respectively, which will begin to expire in 2032. As of December 31, 2025, the Company also had federal research and development tax credit carryforwards of $2.5 million which will begin to expire in 2045.

Utilization of the NOLs and research and development tax credit carryforwards in the United States are subject to annual limitations under Section 382 of the Internal Revenue Code of 1986 due to ownership changes that have occurred previously or that could occur in the future. In general, an ownership change, as defined by Section 382, results from transactions increasing the ownership of certain stockholders or public groups in the stock of a corporation by more than 50% over a three-year period.

The Company completed an analysis under Section 382 for NOLs generated through December 31, 2024, and concluded that an ownership change occurred as of December 30, 2024. As a result of this ownership change a component of the Company’s research and development credits and state NOL carryforwards will expire prior to utilization. Accordingly, the Company has recorded an adjustment to write down its research and development credit and state NOL deferred tax assets in the amount of $21.9 million and $19.0 million, respectively. The write down of these deferred tax assets resulted in a corresponding adjustment to the Company’s valuation allowance.  

The Company may experience ownership changes in the future as a result of subsequent shifts in its stock ownership, some of which may be outside of the Company’s control. These future ownership changes may limit the amount of carryforwards that can be utilized annually to offset future taxable income.

The Company has evaluated the positive and negative evidence bearing upon its ability to realize the deferred tax assets. The Company considered its history of cumulative net losses incurred since inception, its lack of substantial revenue generated to date, and its forecasted future operating losses and concluded that it is more likely than not that the Company will not realize the benefits of its deferred tax assets. Accordingly, a full valuation allowance has been established against the deferred tax assets as of December 31, 2025 and 2024. The Company evaluates positive and negative evidence of its ability to realize deferred tax assets at each reporting period.

Changes in the valuation allowance for deferred tax assets during the years ended December 31, 2025 and 2024, which related primarily to the increases in NOLs, capitalized research and development costs, and research and development tax credit carryforwards, offset by decreases to deferred tax assets associated with research and development tax credits and state NOL carryforwards due to the Section 382 ownership change described above, were as follows:

Year Ended December 31,

(In thousands)

2025

2024

Valuation allowance at beginning of year

$

(224,360)

  ​ ​ ​

$

(195,124)

Decreases recorded as benefit to income tax provision

 

27,249

 

Increases recorded to income tax provision

 

 

(29,236)

Valuation allowance as of end of year

$

(197,111)

$

(224,360)

The Company files tax returns as prescribed by the tax laws of the jurisdictions in which it operates.  In the normal course of business, the Company is subject to examination by federal and state jurisdictions, where applicable. There are currently no pending income tax examinations. The Company’s tax years are still open under statute from 2022 to the present. All open years may be examined to the extent that tax credits or NOLs are used in future periods. The Company’s policy is to record interest and penalties related to income taxes as part of its income tax provision. The Company has not recorded any amounts for unrecognized tax benefits as of December 31, 2025 and 2024.

Historical Timeline

Fiscal YearFiled
2025Feb 26, 2026Showing above
2024Feb 27, 2025
2023Feb 27, 2024
2022Feb 23, 2023
2021Feb 24, 2022
2020Feb 25, 2021
2019Feb 25, 2020
2018Mar 18, 2019
2017Mar 12, 2018
2016Mar 15, 2017
2015Mar 23, 2016

About Income Taxes Disclosures

The income tax disclosure reveals how much a company actually pays in taxes versus what the statutory rate would predict. Analysts focus on the effective tax rate (ETR) reconciliation, which breaks down every item driving the gap between the 21% federal rate and the company's reported ETR — including R&D credits, foreign rate differentials, and state taxes. Deferred tax assets (DTAs) and their valuation allowances signal management's confidence in future profitability: a rising allowance suggests the company doubts it can use accumulated tax benefits. Uncertain tax benefit (UTB) reserves quantify exposure to IRS challenges on aggressive positions.

Key signals to watch: sudden ETR drops without clear operational reasons, large increases in valuation allowances, growing UTB balances, and significant unremitted foreign earnings. Post-TCJA, pay attention to GILTI and BEAT provisions that affect multinational tax structures. Compare the cash taxes paid (from the cash flow statement) against the income tax provision to gauge earnings quality.