11.
Income Taxes

Income (Loss) before provision for income taxes were as follows in each period presented:

 

 

Year Ended December 31,

 

 

 

2025

 

 

2024

 

 

 

(in thousands)

 

United States

 

$

32,737

 

 

$

(85,311

)

Foreign

 

 

(18

)

 

 

(104

)

Total income (loss) before provision for income taxes

 

$

32,719

 

 

$

(85,415

)

The components of provision for income taxes were as follows in each period presented:

 

 

Year Ended December 31,

 

 

 

2025

 

 

2024

 

 

 

(in thousands)

 

Current provision for (benefit from) income taxes:

 

 

 

 

 

 

Federal

 

$

 

 

$

 

State

 

 

3

 

 

 

 

Foreign

 

 

28

 

 

 

(12

)

Total current provision for income taxes

 

$

31

 

 

$

(12

)

 

 

 

 

 

 

 

Deferred provision for (benefit from) income taxes:

 

 

 

 

 

 

Federal

 

$

 

 

$

 

State

 

 

 

 

 

 

Foreign

 

 

 

 

 

 

Total deferred tax provision for (benefit from) income taxes

 

$

 

 

$

 

Provision for (benefit from) income taxes

 

$

31

 

 

$

(12

)

We adopted ASU 2023-09 "Income Taxes (Topic 740): Improvements To Income Tax Disclosures" on a prospective basis beginning with the year ended December 31, 2025. The following table presents required disclosure pursuant to ASU 2023-09 and reconciles the U.S. federal statutory tax amount and rate to our actual global effective amount and rate for the year ended December 31, 2025:

 

 

Year Ended December 31, 2025

 

 

 

Amount

 

 

Percent

 

 

 

(in thousands)

 

 

 

 

U.S. Federal Statutory Tax Rate

 

$

6,871

 

 

 

21.0

%

State & local income taxes, net of federal income tax effect*

 

 

(103

)

 

 

(0.3

)%

Foreign Tax Effects

 

 

32

 

 

 

0.1

%

Changes in valuation allowances

 

 

(14,255

)

 

 

(43.6

)%

Nontaxable or Nondeductible Items

 

 

 

 

 

 

Impact of Stock Compensation

 

 

6,610

 

 

 

20.2

%

Royalty Monetization

 

 

751

 

 

 

2.3

%

Other

 

 

17

 

 

 

0.1

%

Changes in unrecognized tax benefits

 

 

105

 

 

 

0.3

%

Other

 

 

3

 

 

 

%

Total income tax expense

 

$

31

 

 

 

0.1

%

 

* State taxes in California made up the majority (greater than 50 percent) of the tax effect in this category.

The following table presents the required disclosures prior to our adoption of ASU 2023-09 and reconciles the U.S. federal statutory income tax rate to the actual global effective income tax rate for the year ended December 31, 2024:

 

 

Year Ended December 31,

 

 

 

2024

 

Federal income taxes at statutory rate

 

 

21.0

%

Research tax credits

 

 

(26.8

%)

Stock-based compensation

 

 

(16.2

%)

Other

 

 

(1.3

%)

Change in valuation allowance

 

 

23.3

%

Effective tax rate

 

 

0.0

%

The income taxes paid by the Company are as follows:

 

 

Year Ended December 31, 2025

 

 

 

(in thousands)

 

Federal

 

$

 

State

 

 

3

 

Foreign

 

 

 

Switzerland

 

 

187

 

Total income taxes paid

 

$

190

 

Deferred tax assets and liabilities reflect the net tax effects of (a) temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes and (b) operating loss and tax credit carryforwards. Significant components of our deferred tax assets and liabilities were as follows for each of the dates presented:

 

 

As of December 31,

 

 

 

2025

 

 

2024

 

 

 

(in thousands)

 

Deferred tax assets:

 

 

 

 

 

 

Net operating loss carryforwards

 

$

289,520

 

 

$

259,376

 

Deferred revenue

 

 

 

 

 

14,709

 

Tax credit carryforwards

 

 

8,351

 

 

 

8,216

 

License fees

 

 

4,264

 

 

 

4,794

 

Stock-based compensation

 

 

99

 

 

 

5,789

 

Capitalized research expenses

 

 

41,945

 

 

 

61,113

 

Operating lease liabilities

 

 

2,432

 

 

 

9,403

 

Other

 

 

10,088

 

 

 

13,748

 

Total deferred tax assets

 

$

356,699

 

 

$

377,148

 

Valuation allowance

 

 

(355,043

)

 

 

(368,401

)

Net deferred tax assets

 

$

1,656

 

 

$

8,747

 

 

 

 

 

 

 

Deferred tax liabilities:

 

 

 

 

 

 

Operating lease assets

 

 

(1,656

)

 

 

(8,747

)

Total deferred tax liabilities

 

$

(1,656

)

 

$

(8,747

)

 

 

 

 

 

 

Net deferred tax assets (liabilities)

 

$

 

 

$

 

 

We recognize deferred income taxes for temporary differences between the basis of assets and liabilities for financial statement and income tax purposes, as well as for tax attribute carryforwards. We regularly evaluate the positive and negative evidence in determining the realizability of our deferred tax assets. Based upon the weight of available evidence, which includes our historical operating performance and reported cumulative net losses since inception, we maintained a full valuation allowance on the net deferred tax assets as of December 31, 2025 and December 31, 2024. We intend to maintain a full valuation allowance on our deferred tax assets until sufficient positive evidence exists to support reversal of the valuation allowance. The valuation allowance decreased by $13.4 million for the year ended December 31, 2025 and increased by $106.6 million for the year ended December 31, 2024.

As of December 31, 2025, we reported U.S. federal and state NOLs of approximately $1,361.4 million and $72.7 million,

respectively. Our federal NOLs generated prior to 2018 aggregating to $15.3 million will continue to be governed by the NOL tax rules as they existed prior to the adoption of the Tax Act, which means that generally they will expire 20 years after they were generated if not used prior thereto. Many states have similar laws, and our state NOLs will begin to expire in 2030. Accordingly, these federal and state NOLs could expire unused and be unavailable to offset future income tax liabilities. Under the Tax Act, as modified by the CARES Act, federal NOLs incurred in 2018 and in future years may be carried forward indefinitely, but the utilization of such federal NOLs is limited to 80% of current year taxable income. Not all states conform to the Tax Act or CARES Act and other states have varying conformity to the Tax Act or CARES Act.

As of December 31, 2025, we generated federal research and development tax credit carryforwards of $1.1 million, which will begin to expire in 2044. As of December 31, 2025, we had state credit carryforwards of $46.1 million available to reduce future tax liabilities, which do not expire.

On July 4, 2025, the One Big Beautiful Bill (“OBBBA”) was signed into law. The OBBBA includes a broad range of U.S. tax reform measures, including, among other provisions, the immediate expensing of U.S. research and development expenditures. In accordance with ASC 740, the Company has recognized the effects of the new tax law in the period of enactment. As the Company maintains a full valuation allowance on its U.S. deferred tax assets, the legislation does not have a material impact on its consolidated financial statements.

Under Section 382 of the Internal Revenue Code of 1986, as amended (the “Code”), our ability to utilize net operating loss carryforwards or other tax attributes in any taxable year may be limited if we have experienced an “ownership change.” Generally, a Section 382 “ownership change” occurs if one or more stockholders or groups of stockholders who owns at least 5% of a corporation’s stock increases its ownership by more than 50 percentage points over its lowest ownership percentage within a specified testing period. Similar rules may apply under state tax laws.

We have completed a Section 382 study of transactions in our stock through December 31, 2024. The study concluded that we have experienced ownership changes since inception and that our utilization of net operating loss carryforwards and tax credits will be subject to annual limitations. The annual limitations did result in the expiration of tax attribute carryforwards prior to utilization. As of December 31, 2025, no additional ownership change occurred.

The changes in the balance of gross unrecognized tax benefits, which excludes interest and penalties, for the years ended December 31, 2024 and 2025 are as follows:

 

(In thousands)

 

Balance as of January 1, 2024

$

160,346

 

Gross increases for current year tax positions

 

1,011

 

Gross decreases for current year tax positions

 

 

Gross increases for prior year tax positions

 

647

 

Gross decreases for prior year tax positions

 

(124,071

)

Balance as of December 31, 2024

$

37,933

 

Gross increases for current year tax positions

 

133

 

Gross decreases for current year tax positions

 

 

Gross increases for prior year tax positions

 

 

Gross decreases for prior year tax positions

 

 

Balance as of December 31, 2025

$

38,066

 

We currently have a full valuation allowance against its U.S. net deferred tax assets, which would impact the timing of the effective tax rate benefit should any uncertain tax position be favorably settled in the future.

Our policy is to account for interest and penalties related to uncertain tax positions as a component of the income tax provision. The Company has not accrued interest and penalties as of December 31, 2025 due to available tax losses.

Our significant jurisdictions are the U.S. federal jurisdiction and the California state jurisdiction. All of our tax years remain open to examination by the U.S. federal and California tax authorities.

Historical Timeline

Fiscal YearFiled
2025Mar 16, 2026Showing above
2024Mar 7, 2025
2023Mar 28, 2024
2022Feb 8, 2023
2021Feb 28, 2022
2020Mar 1, 2021
2019Feb 27, 2020
2018Feb 26, 2019
2017Feb 27, 2018
2016Mar 9, 2017
2015Mar 4, 2016

About Income Taxes Disclosures

The income tax disclosure reveals how much a company actually pays in taxes versus what the statutory rate would predict. Analysts focus on the effective tax rate (ETR) reconciliation, which breaks down every item driving the gap between the 21% federal rate and the company's reported ETR — including R&D credits, foreign rate differentials, and state taxes. Deferred tax assets (DTAs) and their valuation allowances signal management's confidence in future profitability: a rising allowance suggests the company doubts it can use accumulated tax benefits. Uncertain tax benefit (UTB) reserves quantify exposure to IRS challenges on aggressive positions.

Key signals to watch: sudden ETR drops without clear operational reasons, large increases in valuation allowances, growing UTB balances, and significant unremitted foreign earnings. Post-TCJA, pay attention to GILTI and BEAT provisions that affect multinational tax structures. Compare the cash taxes paid (from the cash flow statement) against the income tax provision to gauge earnings quality.