13.Income Taxes

The components of loss from continuing operations before income taxes are as follows:

Year Ended December 31, 

(in thousands)

  ​ ​ ​

2025

  ​ ​ ​

2024

Domestic

$

(183,124)

$

(215,394)

Foreign

 

 

Total

$

(183,124)

$

(215,394)

No income tax provision or benefit was recorded for the years ended December 31, 2025 and 2024, as the Company did not generate taxable income and maintained a full valuation allowance against its deferred tax assets.

The reconciliation of the statutory United States federal income tax rate to the Company’s loss from continuing operations before income taxes reflecting the Company’s adoption of ASU 2023-09 is as follows:

Year Ended December 31,

2025

2024

(amount in thousands)

Amount

 

Percent

Amount

 

Percent

 

United States federal statutory income tax rate

$

(38,456)

21.0

%  

$

(45,233)

21.0

%  

Permanent items

(9)

 

(482)

0.2

Research and development credit

 

(1,573)

0.9

 

(4,991)

2.3

Stock-based compensation costs

12,088

(6.6)

8,965

(4.1)

Change in unrecognized tax benefit

(237)

0.1

116

(0.1)

Other

(277)

0.1

 

1,596

(0.7)

Change in valuation allowance

28,464

(15.5)

40,029

(18.6)

Effective income tax rate

$

%  

$

%  

The components of the Company’s net deferred tax assets (liabilities) as of December 31, 2025 and 2024 consist of the following:

December 31, 

(in thousands)

  ​ ​ ​

2025

  ​ ​ ​

2024

Deferred tax assets:

Net operating loss carryforwards

$

174,237

$

158,090

Research and development credits

 

74,844

 

72,031

Depreciation and amortization

 

26,598

 

28,861

Stock-based compensation

 

18,004

 

26,814

Sales related accruals

 

5,287

 

39,966

Other accruals

 

31,622

 

42,537

Capitalized research and development

44,960

50,850

Total gross deferred tax assets

 

375,552

 

419,149

Valuation allowance

 

(368,124)

 

(412,833)

Total net deferred tax assets

7,428

6,316

Deferred tax liabilities:

Right-of-use asset

 

(656)

 

(1,004)

In-process research and development

 

(5,832)

 

(6,414)

Section 481(a) adjustment

(2,042)

Total deferred tax liabilities

 

(8,530)

 

(7,418)

Net deferred tax liabilities

$

(1,102)

$

(1,102)

The tax benefit of net operating losses, temporary differences and credit carry forwards is recorded as an asset to the extent that management assesses that realization is “more likely than not.” The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the periods in which the temporary differences representing net future deductible amounts become deductible. As of December 31, 2025 and 2024, the Company recorded net a deferred tax liability of $1.1 million. The net deferred tax liability relates to in-process research and development that cannot be offset against the deferred tax assets. For remaining deferred tax assets, the Company has determined that it is more likely than not that its federal and state net deferred tax assets will not be realized due to the Company's history of losses and lack of other positive evidence. As a result, the Company has recorded a valuation allowance against the remaining federal and certain state net deferred tax assets as of December 31, 2025 and 2024.

The valuation allowance decreased by $44.7 million during the year ended December 31, 2025 and decreased by $10.6 million during the year ended December 31, 2024.

As of December 31, 2025, the Company had net operating loss carryforwards for federal income of $792.6 million, which will start to expire in the year 2036, and various states net operating loss carryforwards of $131.9 million, which have various expiration dates beginning in 2031.

As of December 31, 2025, the Company had federal research and development credit carryforwards for federal income tax purposes of $69.0 million, which will start to expire in the year 2031, and state research and development credit carryforwards of $31.1 million, which have no expiration date.

Utilization of the net operating loss and tax credit carryforwards may be subject to a substantial annual limitation due to ownership change limitations provided by Section 382 of the Internal Revenue Code of 1986, as amended, and similar state provisions. The annual limitation may result in the expiration of certain net operating loss and tax credit carryforwards before their utilization. Under the current tax law, the carry forward period of net operating losses generated from 2018 forward is indefinite. However, the carryforward period for net operating losses generated prior to 2018 remains the same. Therefore, the annual limitation may result in the expiration of certain net operating losses and tax credit carryforwards before their utilization. The Company files income tax returns in the United States federal jurisdiction, various United States state jurisdictions, and a foreign jurisdiction with varying statutes of limitations. The tax years from inception in 2011 forward remain open to examination due to the carryover of unused net operating losses and tax credits.

A reconciliation of the Company’s unrecognized tax benefits during 2025 and 2024 is as follows:

Year Ended December 31, 

(in thousands)

  ​ ​ ​

2025

  ​ ​ ​

2024

Balance at beginning of year

$

19,247

$

17,417

Additions based on tax positions related to current year

 

1,050

 

1,565

Additions (reductions) for tax positions of prior years

 

(280)

 

265

Balance at end of year

$

20,017

$

19,247

As of December 31, 2025 and 2024, the Company had approximately $20.0 million and $19.2 million, respectively, of unrecognized benefits, none of which would currently affect the Company’s effective tax rate if recognized due to the Company’s deferred tax assets being offset by a valuation allowance. During 2025 and 2024, the Company did not recognize accrued interest and penalties related to unrecognized tax benefits.

On July 4, 2025, the One Big Beautiful Bill Act (the “OBBBA”) was signed into law in the United States. This comprehensive tax legislation contains a broad range of tax reforms, including provisions that allow for the immediate expensing of domestic research and development expenses, restore and make permanent 100% bonus depreciation for qualifying assets, and ease limitations on the deductibility of interest expense. The legislation has multiple effective dates, with certain provisions taking effect in 2025 and others being implemented through various future years. The Company has accounted for the provisions of the OBBBA in its financial statements. The changes did not impact income taxes due to its cumulative tax loss and tax effect of a full valuation allowance against those balances.

Historical Timeline

Fiscal YearFiled
2025Mar 9, 2026Showing above
2024Mar 17, 2025
2023Mar 15, 2024
2022Mar 6, 2023
2021Feb 23, 2022
2020Feb 25, 2021
2019Feb 27, 2020
2018Feb 28, 2019
2017Mar 8, 2018
2016Mar 14, 2017
2015Feb 29, 2016

About Income Taxes Disclosures

The income tax disclosure reveals how much a company actually pays in taxes versus what the statutory rate would predict. Analysts focus on the effective tax rate (ETR) reconciliation, which breaks down every item driving the gap between the 21% federal rate and the company's reported ETR — including R&D credits, foreign rate differentials, and state taxes. Deferred tax assets (DTAs) and their valuation allowances signal management's confidence in future profitability: a rising allowance suggests the company doubts it can use accumulated tax benefits. Uncertain tax benefit (UTB) reserves quantify exposure to IRS challenges on aggressive positions.

Key signals to watch: sudden ETR drops without clear operational reasons, large increases in valuation allowances, growing UTB balances, and significant unremitted foreign earnings. Post-TCJA, pay attention to GILTI and BEAT provisions that affect multinational tax structures. Compare the cash taxes paid (from the cash flow statement) against the income tax provision to gauge earnings quality.